Mazzuca, Carmen Vitiello, Laura Travaglini, Silvia Maurizi, Fatima Finamore, Panaiotis Santangelo, Simona Rigon, Amelia Vadacca, Marta Angeletti, Silvia Scarlata, Simone
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Published in
Frontiers in Immunology
α -1 antitrypsin (A1AT) is a 52 kDa acute-phase glycoprotein belonging to the serine protease inhibitor superfamily (SERPIN). It is primarily synthesized by hepatocytes and to a lesser extent by monocytes, macrophages, intestinal epithelial cells, and bronchial epithelial cells. A1AT is encoded by SERPINA1 locus, also known as PI locus, highly poly...
Sharma, Amrita Sanz-Rodriguez, Carlos E. Pollastri, Michael P. Purmal, Andrei Mensa-Wilmot, Kojo
Published in
Frontiers in Drug Discovery
The criteria for the progression of hits in the discovery of leads for human African trypanosomiasis (HAT), a neglected disease caused by the microbial eukaryote Trypanosoma brucei, are not standardized. Hits are advanced upon meeting thresholds for drug-like molecules. Following those principles, pharmacokinetics (Cmax and AUC0–6h) and anti-trypan...
Kunkel, Alyssa A McHugh, Kevin J
Published in
Journal of biomedical materials research. Part A
Pharmaceutical drugs, including vaccines, pre- and post-exposure prophylactics, and chronic drug therapies, are crucial tools in the prevention and treatment of infectious diseases. These drugs have the ability to increase survival and improve patient quality of life; however, infectious diseases still accounted for more than 10.2 million deaths in...
Neujahr, Alison Clare (Bartenslager)
With the ever-increasing demand for animal protein and the continual need for the assurance of proper animal welfare, investigations of preventative strategies for diseases is greatly needed. Specifically in the cattle industry, infectious bovine keratoconjunctivitis (IBK), commonly known as pinkeye, causes a large economic loss to the producer. Ho...
Moniz, Marta Pereira, Sofia Soares, Patricia Aguiar, Pedro Donato, Helena Leite, Andreia
Published in
Frontiers in Public Health
Objectives This study aimed to systematically appraise risk factors associated with SARS-CoV-2 infection in high-income countries during the period of predominance of the Alpha variant (January 2020 to April 2021). Methods Four electronic databases were used to search observational studies. Literature search, study screening, data extraction and qu...
Singh, Surabhi Ahmed, Amina Ismail Almansoori, Sumayya Alameri, Shaikha Adlan, Ashraf Odivilas, Giovanni Chattaway, Marie Anne Salem, Samara Bin Brudecki, Grzegorz Elamin, Wael
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Published in
Frontiers in Public Health
Introduction The emergence and resurgence of pathogens have led to significant global health challenges. Wastewater surveillance has historically been used to track water-borne or fecal-orally transmitted pathogens, providing a sensitive means of monitoring pathogens within a community. This technique offers a comprehensive, real-time, and cost-eff...
Zhang, Huiling Wang, Juan Zhang, Kunlun Shi, Jianyang Gao, Yameng Zheng, Jingying He, Jingtong Zhang, Jing Song, Yang Zhang, Ruifei
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Published in
Frontiers in Public Health
Introduction Persistent infections caused by certain viruses and parasites have been associated with multiple diseases and substantial mortality. Heavy metals are ubiquitous environmental pollutants with immunosuppressive properties. This study aimed to determine whether heavy metals exposure suppress the immune system, thereby increasing the susce...
Zhu, Wei Zhang, Jizhen Yang, Liyao Li, Jiping Guo, Hongxia
Published in
Frontiers in Public Health
Background Nurses’ competencies are crucial for infectious disease prevention and control. We aimed to investigate competencies in responding to infectious disease outbreaks of nurses in primary healthcare institutions and identify their training needs. Methods A cross-sectional study was conducted from June to September 2022, recruiting nurses fro...
Manca, Alessandra Cusato, Jessica
Published in
Frontiers in Pharmacology
Paulus, Kirsten Bass, Sarah Bauerle Kelly, Patrick J. A. Pilla, Jenine Otor, AnnaMarie Scialanca, Madison Arroyo, Anamarys Faison, Namaijah
Published in
Advances in Drug and Alcohol Research
Introduction The Health Belief Model (HBM) has been successfully applied to understanding adherence to COVID-19 prevention practices. It has not, however, been used to understand behavior in people who use drugs (PWUD). The aim of this study was to use the HBM to better understand COVID-19 perceptions among PWUD and understand how resiliency affect...
