Ezz Eldin, Rogy R Saleh, Marwa A Alotaibi, Mohammad Hayal Alsuair, Reem K Alzahrani, Yahya A Alshehri, Feras A Mohamed, Amany F Hafez, Shaimaa M Althoqapy, Azza Ali Khirala, Seham K
...
Published in
Journal of enzyme inhibition and medicinal chemistry
Herein, a series of N'-benzylidene-3,4-dimethoxybenzohydrazide derivatives were designed and synthesised to target the multidrug efflux pump (MATE). The antibacterial activities were screened against S. aureus, Acinetobacter, S. typhi, E. coli, and P. aeruginosa, whereas their antifungal activities were screened against C. albicans. Compounds 4a, 4...
reagen;, sarah
The advancing field of nanoscience has produced lower mass, smaller size, and expanded chemical composition nanoparticles over recent years. These new nanoparticles have challenged traditional analytical methods of qualification and quantification. Such advancements in nanoparticles and nanomaterials have captured the attention of toxicologists wit...
Boyle, Alexander Buckenham Uri Ke, James Ragg, Amanda MacLean, Simon B M
Published in
Journal of shoulder and elbow surgery
On the basis of the current literature, the optimal surgical technique for distal biceps tendon tears remains controversial. Cadaveric studies have investigated distal biceps anatomy but are limited by cohort size and tissue factors. We sought to investigate distal biceps anatomy in vivo by retrospectively reviewing magnetic resonance imaging (MRI)...
Sahu, Aditi Cordero, Jose Wu, Xiancheng Kossatz, Susanne Harris, Ucalene Franca, Paula Demetrio Desouza Kurtansky, Nicholas R Everett, Niasia Dusza, Stephen Monnier, Jilliana
...
Published in
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Reflectance confocal microscopy (RCM) with endogenous backscattered contrast can noninvasively image basal cell carcinomas (BCCs) in skin. However, BCCs present with high nuclear density, and the relatively weak backscattering from nuclei imposes a fundamental limit on contrast, detectability, and diagnostic accuracy. We investigated PARPi-FL, an e...
Determe, Sébastien Rompen, Eric LECLOUX, Geoffrey DE CARVALHO, Bruno LAMBERT, France Van hede, Dorien
Background & Aim: Patient specific 3D-printed ceramic scaffolds represent a promising solution to reconstruct large intra-oral bone defects. Although the scaffold internal design is known to influence the biomaterial regenerative performances, in silico modelling is largely underused to optimize it. This in vivo study aimed to evaluate the bone reg...
marković, jelena
Diabetes mellitus is a frequent endocrine disorder characterized by hyperglycemia. Acrylamide (AA) is food contaminant formed during the high-temperature processing of food rich in carbohydrates and low in proteins. Recent human epidemiological studies have shown a potential association between AA exposure and the prevalence of diabetes in the gene...
marković, jelena
Acrylamide (AA) toxicity is associated with oxidative stress. During detoxification, AA is either coupled to gluthatione or biotransformed to glycidamide by the enzyme cytochrome P450 2E1 (CYP2E1). The aim of our study was to examine the hepatotoxicity of AA in vivo and in vitro. Thirty male Wistar rats were treated with 25 or 50 mg/kg b.w. of AA f...
Silva, M. Malmberg, M. Otienoburu, S. D. Björkman, A. Ngasala, B. Mårtensson, A. Gil, J. P. Veiga, M. I.
Published in
Frontiers in Pharmacology
Background: Artemisinin-based combination therapies (ACTs) are the global mainstay treatment of uncomplicated Plasmodium falciparum infections. PfMDR1 and PfCRT are two transmembrane transporters, associated with sensitivity to several antimalarials, found in the parasite food vacuole. Herein, we explore if their relatedness extends to overlapping ...
chakniramol;, sukwasa
Biological molecules in nutraceuticals and functional foods have proven physiological properties to treat human chronic diseases. These molecules contribute to applications in the food and pharmaceutical industries by preventing food spoilage and cellular injury. Technological advancement in the screening and characterization of bioactive peptides ...
How, Chee Wun Teoh, Siew Li Loh, Jian Sheng Tan, Stella Li Kar Foo, Jhi Biau Ng, Hui Suan Wong, Stephenie Yoke Wei Ong, Yong Sze
Published in
Frontiers in Pharmacology
The conventional concept of using nanocarriers to deliver chemotherapeutic drugs has advanced to accommodate additional diagnostic capability. Nanotheranostic agents (NTA), combining both treatment and diagnostic tools, are an ideal example of engineering-health integration for cancer management. Owing to the diverse materials used to construct NTA...
