Shan, Shengzhou Fang, Bin Zhang, Yifan Wang, Chuandong Zhou, Jia Niu, Chenguang Gao, Ya Zhao, Danyang He, Jiahao Wang, Jing
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Published in
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Macrophages (Mφs) can be used as a part of cell-based cancer immunotherapy. However, they may be hampered by a failure to effectively and stably regulate their polarization state to enhance their tumoricidal effects. In this work, mechanical stretch (MS), as a biology-free modulatory method, was shown to enhance M1 polarization and tumoricidal effe...
Chew, Guo-Liang Campbell, Amy E De Neef, Emma Sutliff, Nicholas A Shadle, Sean C Tapscott, Stephen J Bradley, Robert K
Published in
Developmental cell
Advances in cancer immunotherapies make it critical to identify genes that modulate antigen presentation and tumor-immune interactions. We report that DUX4, an early embryonic transcription factor that is normally silenced in somatic tissues, is re-expressed in diverse solid cancers. Both cis-acting inherited genetic variation and somatically acqui...
Li, Tianjiao Li, Hao Li, Shuo Xu, Shuaishuai Zhang, Wuhu Gao, Heli Xu, Huaxiang Wu, Chuntao Wang, Wenquan Yu, Xianjun
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Published in
Cancer medicine
Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant cancer with limited treatment options. Chimeric antigen receptor T cells (CAR-T) are genetically engineered T cells that can specifically kill tumor cells without major histocompatibility complex restriction. Encouraging progress in CAR-T therapy for PDAC has been made in preclinical and...
Dittmer, Ulf Sutter, Kathrin Kassiotis, George Zelinskyy, Gennadiy Bánki, Zoltán Stoiber, Heribert Santiago, Mario L Hasenkrug, Kim J
Published in
FEMS microbiology reviews
Approximately 4.4% of the human genome is comprised of endogenous retroviral sequences, a record of an evolutionary battle between man and retroviruses. Much of what we know about viral immunity comes from studies using mouse models. Experiments using the Friend virus (FV) model have been particularly informative in defining highly complex anti-ret...
Cao, Rui Ma, Jie-Tao Zhang, Shu-Ling Sun, Li Liu, Yang Zhang, Xiang-Yan Jing, Wei Huang, Le-Tian Han, Cheng-Bo
Published in
Cancer medicine
To compare the relative efficacy of immune checkpoint inhibitors (ICIs) or chemotherapy (CT) alone, or their combination modality in the first-line treatment of advanced nonsmall cell lung cancer (NSCLC). This meta-analysis was performed on the eligible randomized controlled trials (RCTs) after searching web databases and meeting abstracts. The mai...
Triplett, James D Hardy, Todd A Riminton, D Sean Chu, Shannon Y K Reddel, Stephen W
Published in
Muscle & nerve
Muscle-specific tyrosine kinase (MuSK) autoantibody related myasthenia gravis is characterized by bulbar and respiratory manifestations, a poor response to anticholinergics, and a generally good response to plasma exchange and rituximab. It is not known if MuSK-antibody (Ab) levels could be used to predict the clinical course Methods: Three patient...
Hughes, Michael S Zheng, Hui Zubiri, Leyre Molina, Gabriel E Chen, Steven T Mooradian, Meghan J Allen, Ian M Reynolds, Kerry L Dougan, Michael
Published in
Cancer medicine
Immune checkpoint inhibitors (CPIs) have revolutionized oncologic therapy but can lead to immune-related adverse events (irAEs). Corticosteroids are first-line treatment with escalation to biologic immunosuppression in refractory cases. CPI-related gastroenterocolitis (GEC) affects 20%-50% of patients receiving CPIs and can carry significant morbid...
Heath, B R Michmerhuizen, N L Donnelly, C R Sansanaphongpricha, K Sun, D Brenner, J C Lei, Y L
Published in
Journal of dental research
The success of immune checkpoint receptor blockade has brought exciting promises for the treatment of head and neck squamous cell carcinoma (HNSCC). While patients who respond to checkpoint inhibitors tend to develop a durable response,
Cohen, Leah Tsai, Kenneth Y
Published in
Molecular carcinogenesis
Merkel cell carcinoma (MCC) is a rare neuroendocrine carcinoma of the skin, for which the exact mechanisms of carcinogenesis remain unknown. Therapeutic options for this highly aggressive malignancy have historically been limited in both their initial response and response durability. Recent improvements in our understanding of MCC tumor biology ha...
Ramelyte, Egle Dummer, Reinhard Guenova, Emmanuella
Published in
Expert opinion on investigational drugs
Introduction: Cutaneous T-cell lymphoma (CTCL) is a heterogeneous group of skin-homing T-cell neoplasms, which represent approximately 75% of all primary cutaneous lymphomas. Mycosis fungoides and Sézary syndrome are the most common CTCL. Early stage disease follows a protracted course, carries a 5-year disease specific survival of 97% and can be t...
