Kleiboeker, Hanna L Prom, Alyson Paplaczyk, Krista Myers, Catherine N
Published in
The Annals of pharmacotherapy
To review the efficacy and safety of eculizumab for prevention and treatment of antibody-mediated rejection (AMR) in lung transplant recipients (LTRs). A literature search of PubMed and the Cochrane Controlled Trials Register (2007 to mid-October 2023) was performed using the following search terms: eculizumab, complement inhibitor, solid organ tra...
Yao, Min Ullrich, Evelyn Albini, Adriana
Published in
Frontiers in Immunology
Park, Chan-Su Guan, Jian Rhee, Peter Gonzalez, Federico Lee, Hee-Sung Park, Ji-Hyun Coscoy, Laurent Robey, Ellen Shastri, Nilabh Sadegh-Nasseri, Scheherazade
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The fate of developing T cells is determined by the strength of T cell receptor (TCR) signal they receive in the thymus. This process is finely regulated through the tuning of positive and negative regulators in thymocytes. The Family with sequence similarity 49 member B (Fam49b) protein is a newly discovered negative regulator of TCR signaling tha...
Nicola, Stefania Borrelli, Richard Corradi, Federica Lo Sardo, Luca Badiu, Iuliana Romito, Alessandra Rashidy, Nicolò Quinternetto, Anna Mazzola, Marina Meli, Federico
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Published in
Frontiers in Immunology
Background Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by a variety of both signs and symptoms; it mainly affects women of childbearing age, with an estimated prevalence of 24/100,000 people in Europe and North America. SLE is often described as an antibodies-driven disease as its clinical manifestations are us...
Kahn, Richard Virk, Harvinder Laflamme, Carl Houston, Douglas Polinski, Nicole Meijers, Rob Levey, Allan Saper, Clifford Errington, Timothy Turn, Rachel
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Antibodies are used in many areas of biomedical and clinical research, but many of these antibodies have not been adequately characterized, which casts doubt on the results reported in many scientific papers. This problem is compounded by a lack of suitable control experiments in many studies. In this article we review the history of the antibody c...
An, Wenhao Zhou, Jiajun Qiu, Zhiqiang Wang, Peishen Han, Xinye Cheng, Yanwen He, Zi An, Yihua Li, Shouwei
Published in
Frontiers in Immunology
Background Advancements in modern medicine have extended human lifespan, but they have also led to an increase in age-related diseases such as Alzheimer’s disease (AD) and atherosclerosis (AS). Growing research evidence indicates a close connection between these two conditions. Methods We downloaded four gene expression datasets related to AD and A...
Xing, Xiaoming Zhao, Cong Cai, Song Wang, Jing Zhang, Jing Sun, Fang Huang, Mao Zhang, Lishan
Published in
Frontiers in Immunology
Background Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease characterized by progressive fibrosis, leading to impaired gas exchange and high mortality. The etiology of IPF is complex, with potential links to autoimmune disorders such as hypothyroidism. This study explores the relationship between hypothyroidism and IPF, focusing on the ...
Long, Dan Mao, Chenhan Xu, Yin Zhu, Ying
Published in
Frontiers in Immunology
Ulcerative colitis (UC) is characterized by chronic non-recessive inflammation of the intestinal mucosa involving both innate and adaptive immune responses. Currently, new targeted therapies are urgently needed for UC, and neutrophil extracellular traps (NETs) are new therapeutic options. NETs are DNA-based networks released from neutrophils into t...
Yaneselli, Kevin Ávila, Gimena Rossi, Andrea Rial, Analía Castro, Sabrina Estradé, María José Suárez, Gonzalo Algorta, Agustina
Published in
Frontiers in Veterinary Science
Platelet lysate (PL) is investigated as a potential replacement for fetal bovine serum (FBS) in cell culture. However, there is limited research on its impact on the immune profile of equine mesenchymal stromal cells (eMSCs). This study aimed to evaluate the effects of different PL formulations on the proliferative capacity, multipotentiality, and ...
Shaikh, Mohd Sayeed Faiyazuddin, Md. Khan, Mubasshera Sabir Pathan, Shahbaz K. Syed, Imran J. Gholap, Amol D. Akhtar, Mohammad Shabib Sah, Ranjit Mehta, Rachana Sah, Sanjit
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Published in
Frontiers in Microbiology
Chikungunya virus (CHIKV), a single-stranded RNA virus transmitted by Aedes mosquitoes, poses a significant global health threat, with severe complications observed in vulnerable populations. The only licensed vaccine, IXCHIQ, approved by the US FDA, is insufficient to address the growing disease burden, particularly in endemic regions lacking herd...
