Ferretti, Andrew P Kula, Tomasz Wang, Yifan Nguyen, Dalena M V Weinheimer, Adam Dunlap, Garrett S Xu, Qikai Nabilsi, Nancy Perullo, Candace R Cristofaro, Alexander W
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Published in
Immunity
Developing effective strategies to prevent or treat coronavirus disease 2019 (COVID-19) requires understanding the natural immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We used an unbiased, genome-wide screening technology to determine the precise peptide sequences in SARS-CoV-2 that are recognized by the memory C...
Bianchi, Silvia Canuti, Marta Ciceri, Giulia Gori, Maria Colzani, Daniela Dura, Marco Pennati, Beatrice Marina Baggieri, Melissa Magurano, Fabio Tanzi, Elisabetta
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Published in
International Journal of Molecular Sciences
Of the 24 known measles genotypes, only D8 and B3 are responsible for outbreaks in the last years in Europe, Asia, and America. In this study the H gene of 92 strains circulating between 2015 and 2019 in Lombardy, Northern Italy, and 1273 H sequences available in GenBank were analyzed in order to evaluate the genetic variability and to assess the c...
Free, Meghan E Stember, Katherine G Hess, Jacob J McInnis, Elizabeth A Lardinois, Olivier Hogan, Susan L Hu, Yichun Mendoza, Carmen Le, Andrew K Guseman, Alex J
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Published in
Journal of autoimmunity
Treatment of autoimmune diseases has relied on broad immunosuppression. Knowledge of specific interactions between human leukocyte antigen (HLA), the autoantigen, and effector immune cells, provides the foundation for antigen-specific therapies. These studies investigated the role of HLA, specific myeloperoxidase (MPO) epitopes, CD4+ T cells, and A...
Bazarnova, Yulia Bolotnikova, Tatiana Aronova, Ekaterina
Published in
Current Issues in Pharmacy and Medical Sciences
We experimentally carried out the synthesis of the tbf gene that encodes highly-immunogenic epitopes of pathogenic cholera strains, through the cloning of the tbf gene in pGEM-T Easy plasmid. Moreover, we tested the hybrid gene sequence for absence of mutations, using the Sanger sequencing. We also calculated the nucleatic sequence of the tbf gene....
Teixeira, Raíssa M. Couto, Ricardo David
ABSTRACT Among the cardiovascular diseases (CVD), acute myocardial infarction (AMI) is currently considered the most common cause of death and disability worldwide. Several laboratory tests have been developed for the detection of cardiac injury, including troponins that are considered the gold standard marker (surrogate biomarker) of myocardial in...
Rezaee, Majid Asiabanha Rasaee, Mohammad Javad Mohammadnejad, Javad
Published in
Journal of immunoassay & immunochemistry
Human cardiac troponin I (cTni) is the gold marker for early diagnosis of myocardial infarction. In this regard, four immune-dominant epitopes of cTni were predicted and their 3D structures were determined. Thereafter, the competitive performance of the peptides was monitored with the developed polyclonal antibody-based indirect competitive ELISA; ...
Hoffmann, Peter R Panigada, Maddalena Soprana, Elisa Terry, Frances Bandar, Ivo Sah Napolitano, Andrea Rose, Aaron H Hoffmann, Fukun W Ndhlovu, Lishomwa C Belcaid, Mahdi
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Published in
Human vaccines & immunotherapeutics
Our previous work involved the development of a recombinant fowlpox virus encoding survivin (FP-surv) vaccine that was evaluated for efficacy in mesothelioma mouse models. Results showed that FP-surv vaccination generated significant immune responses, which led to delayed tumor growth and improved animal survival. We have extended those previous fi...
Zhang, Xiao Xin, Lu Li, Shaowei Fang, Mujin Zhang, Jun Xia, Ningshao Zhao, Qinjian
Published in
Human vaccines & immunotherapeutics
Recombinant VLP-based vaccines have been successfully used against 3 diseases caused by viral infections: Hepatitis B, cervical cancer and hepatitis E. The VLP approach is attracting increasing attention in vaccine design and development for human and veterinary use. This review summarizes the clinically relevant epitopes on the VLP antigens in suc...
Ivanyi, Juraj
Published in
Frontiers in immunology
Study of the function of epitopes of Mycobacterium tuberculosis antigens contributed significantly toward better understanding of the immunopathogenesis and to efforts for improving infection and disease control. Characterization of genetically permissively presented immunodominant epitopes has implications for the evolution of the host-parasite re...
Gora, M Gardas, A Wiktorowicz, W Hobby, P Watson, P F Weetman, A P Sutton, B J Banga, J P
Published in
Clinical and experimental immunology
Autoantibodies to thyroid peroxidase (TPO) recognize predominantly conformational epitopes, which are restricted to two distinct determinants, termed immunodominant domain region (IDR) A and B. These dominant determinants reside in the region with structural homology to myeloperoxidase (MPO)-like domain and may extend into the adjacent complement c...
