Tateo, Valentina Manuzzi, Lisa De Giglio, Andrea Parisi, Claudia Lamberti, Giuseppe Campana, Davide Pantaleo, Maria Abbondanza
Published in
International journal of molecular sciences
Thymic epithelial tumors (TETs) are a group of rare thoracic malignancies, including thymic carcinomas (TC) and thymomas (Tm). Autoimmune paraneoplastic diseases are often observed in TETs, especially Tms. To date, chemotherapy is still the standard treatment for advanced disease. Unfortunately, few therapeutic options are available for relapsed/re...
Iasella, Carlo J Hoji, Aki Popescu, Iulia Wei, Jianxin Snyder, Mark E Zhang, Yingze Xu, Wei Iouchmanov, Vera Koshy, Ritchie Brown, Mark
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Published in
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Chronic lung allograft dysfunction (CLAD) remains the major complication limiting long-term survival among lung transplant recipients (LTRs). Limited understanding of CLAD immunopathogenesis and a paucity of biomarkers remain substantial barriers for earlier detection and therapeutic interventions for CLAD. We hypothesized the airway transcriptome ...
Candon, Sophie Guerrot, Dominique Drouot, Laurent Lemoine, Mathilde Lebourg, Ludivine Hanoy, Mélanie Boyer, Olivier Bertrand, Dominique
Published in
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Immunosuppressed organ-transplanted patients are considered at risk for severe forms of COVID-19. Moreover, exaggerated innate and adaptive immune responses might be involved in severe progression of the disease. However, no data on the immune response to SARS-CoV-2 in transplanted patients are currently available. Here, we report the first assessm...
Toni, Roberto Di Conza, Giusy Barbaro, Fulvio Zini, Nicoletta Consolini, Elia Dallatana, Davide Antoniel, Manuela Quarantini, Enrico Quarantini, Marco Maioli, Sara
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Published in
Frontiers in Immunology
Osteoporosis stems from an unbalance between bone mineral resorption and deposition. Among the numerous cellular players responsible for this unbalance bone marrow (BM) monocytes/macrophages, mast cells, T and B lymphocytes, and dendritic cells play a key role in regulating osteoclasts, osteoblasts, and their progenitor cells through interactions o...
See, Sarah B Mantell, Benjamin S Clerkin, Kevin J Ray, Bryan Vasilescu, E Rodica Marboe, Charles C Naka, Yoshifumi Restaino, Susan Colombo, Paolo C Addonizio, Linda J
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Published in
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Antibody-mediated rejection (AMR) driven by the development of donor-specific antibodies (DSA) directed against mismatched donor human leukocyte antigen (HLA) is a major risk factor for graft loss in cardiac transplantation. Recently, the relevance of non-HLA antibodies has become more prominent as AMR can be diagnosed in the absence of circulating...
Zou, Dawei Dai, Yulin Zhang, Xiaolong Wang, Guohua Xiao, Xiang Jia, Peilin Li, Xian C Guo, Zhiyong Chen, Wenhao
Published in
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Exhaustion of T cells limits their ability to clear chronic infections or eradicate tumors. Here, in the context of transplant, we investigated whether T cell exhaustion occurs and has a role in determining transplant outcome. A peptide/MHC tetramer-based approach was used to track exhausted CD8+ T cells in a male-to-female skin transplant model. T...
Lee, Young S Zhang, Tianshu Saxena, Vikas Li, Lushen Piao, Wenji Bromberg, Jonathan S Scalea, Joseph R
Published in
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Myeloid-derived suppressor cells (MDSCs) expand in an inflammatory microenvironment such as cancer and autoimmunity. To study if transplantation induces MDSCs and these cells regulate allograft survival, C57BL/6 donor hearts were transplanted into BALB/c recipients and endogenous MDSCs were characterized. The effects of adoptive transfer of transpl...
Marino, Jose Gonzalez-Nolasco, Bruno Wang, Xianding Orent, William Benichou, Gilles
Published in
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Alloreactive memory T cells play a key role in transplantation by accelerating allograft rejection and preventing tolerance induction. Some studies using µMT mice, which are constitutionally devoid of B cells, showed that B cells were required for the generation of memory T cells after allotransplantation. However, whether B cell depletion in norma...
Sabbah, Shereen Liew, Aaron Brooks, Augustin M Kundu, Rhiannon Reading, James L Flatt, Anneliese Counter, Claire Choudhary, Pratik Forbes, Shareen Rosenthal, Miranda J
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Published in
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Islet transplantation is an effective therapy for life-threatening hypoglycemia, but graft function gradually declines over time in many recipients. We characterized islet-specific T cells in recipients within an islet transplant program favoring alemtuzumab (ATZ) lymphodepleting induction and examined associations with graft function. Fifty-eight ...
Hartzell, Susan Bin, Sofia Benedetti, Claudia Haverly, Meredith Gallon, Lorenzo Zaza, Gianluigi Riella, Leonardo V. Menon, Madhav C. Florman, Sander Rahman, Adeeb H.
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Published in
American Journal of Transplantation
Whether kidney transplant recipients are capable of mounting an effective anti‐SARS‐CoV‐2 adaptive immune response despite chronic immunosuppression is unknown and has important implications for therapy. Herein, we analyzed peripheral blood cell surface and intracellular cytokine phenotyping by flow cytometry along with serum antibody testing in 18...
