Published in Journal of Biosciences
Ankyrins (Ank) are ubiquitously expressed proteins that play a critical role in the integrity of cytoskeleton and cellular signalling. Their presence in metazoans and evolutionary conserved protein primary sequence indicates their functional significance. Tissue-specific isoforms and an array of transcript variants make this protein one of the indi...
Published in Virology Journal
BackgroundAfrican swine fever (ASF) leads to high mortality in domestic pigs and wild boar and is caused by the African swine fever virus (ASFV). Currently, no vaccine is commercially available for prevention, and the epidemic is still spreading. Here, we constructed a recombinant pseudorabies virus (PRV) (PRV-ΔgE/ΔgI/ΔTK-(CD2v)) that expresses the...
Published in Mathematical Biosciences
• The interactions between SARS-CoV-2 virus and the immune system is still unclear. • We discuss the impact of a primary infection on a secondary challenge. • Immune dynamics is modeled through increasing probability of severe forms and lethality. • Under immune fragility hypothesis we compute the incidence on challenge.
Published in The Journal of Poultry Science
The goal of this study was to evaluate the influences of mannan oligosaccharides (MOSs) and/or Bifidobacterium on the growth and immunity of pigeons over a 56-day period. One hundred paired adult pigeons were randomly divided into four groups of five paired pigeons. Paired pigeons with two young squabs were housed in a man-made aviary. Parent pigeo...
Published in Immunity
Ferretti et al. reveal specific SARS-CoV-2 epitopes that are broadly shared by CD8+ T cells of COVID-19 patients but exhibit limited cross-reactivity with seasonal coronaviruses. Most epitopes are located outside of the spike protein, suggesting that next-generation vaccines incorporating these epitopes might be needed to generate more robust and d...
Published in Metabolites
In the past decade, the rise of immunometabolism has fundamentally reshaped the face of immunology. As the functions and properties of many (immuno)metabolites have now been well described, their exchange among cells and their environment have only recently sparked the interest of immunologists. While many metabolites bind specific receptors to ind...
Published in Experimental and Therapeutic Medicine
Oral lichen planus (OLP) is a chronic inflammatory disease, associated with altered cell-mediated immunological function. It has long-term evolution, repeated exacerbations, sometimes painful and resistant to treatment, even all of these, OLP significantly affects patient's life quality. Not least, OLP is accompanied by an increased risk of maligna...
BACKGROUND: Hepatitis B virus (HBV) immunity is recommended to optimize outcomes after solid organ transplantation (SOT). This study assessed the prevalence and predictors of HBV immunity at the time patients were placed on transplant waiting list over a period from 1997 to 2019 in a low HBV endemic region. METHODS: Data were obtained from the Univ...
Published in Oncoimmunology
The consensus Immunoscore is a routine assay quantifying the adaptive immune response within the tumor microenvironment. Its evaluation in the primary tumor of patients with stages I/II/III colorectal cancer (CRC) has prognostic value that has been confirmed in multiple studies. For metastatic patients, the evaluation of the consensus Immunoscore w...
Published in Frontiers in Immunology
