Banerjee, Ruma Kumar, Roshan
Published in
Trends in biochemical sciences
The electron transport chain (ETC) is a major currency converter that exchanges the chemical energy of fuel oxidation to proton motive force and, subsequently, ATP generation, using O2 as a terminal electron acceptor. Discussed herein, two new studies reveal that the mammalian ETC is forked. Hypoxia or H2S exposure promotes the use of fumarate as a...
Carullo, Veronica Morrone, Kerry Weiss, Meagan Choi, Jaeun Gao, Qi Pisharoty, Shantanu Moody, Karen Manwani, Deepa
Published in
Pediatric blood & cancer
Sickle cell disease (SCD) is a chronic illness that is associated with frequent admissions for vaso-occlusive episodes (VOE). Opioids are frequently utilized in pain management, but dosing is often provider dependent. Opioids cause both short-term and long-term side effects, so the minimal effective dose is desired. This study examined demand-only ...
Kim, Chu Hyun Lee, Ji Hyun Lee, Ji Won Kim, Eunju Choi, Sang-Hee
Published in
Journal of magnetic resonance imaging : JMRI
While histologic response to neoadjuvant chemotherapy (NChT) is the major prognostic factor for osteosarcoma treatment, evaluating that response is difficult. To evaluate the feasibility of the blood oxygen level-dependent (BOLD) technique to assess the response to NChT. Prospective. Twelve patients with osteosarcoma undergoing NChT. 3 T; T2*-weigh...
Keulers, Tom G Koch, Alexander van Gisbergen, Marike W Barbeau, Lydie M O Zonneveld, Marijke I de Jong, Monique C Savelkouls, Kim G M Wanders, Roel G Bussink, Johan Melotte, Veerle
...
Published in
Autophagy
Hypoxia is a common feature of solid tumors and is associated with increased tumor progression, resistance to therapy and increased metastasis. Hence, tumor hypoxia is a prognostic factor independent of treatment modality. To survive hypoxia, cells activate macroautophagy/autophagy. Paradoxically, in several cancer types, mutations or loss of essen...
Gao, Lin Ortega-Sáenz, Patricia Moreno-Domínguez, Alejandro López-Barneo, José
Published in
Antioxidants & redox signaling
Significance: Acute responses to hypoxia are essential for the survival of mammals. The carotid body (CB), the main arterial chemoreceptor, contains glomus cells with oxygen (O2)-sensitive K+ channels, which are inhibited during hypoxia to trigger adaptive cardiorespiratory reflexes. Recent Advances: In this review, recent advances in molecular mec...
Zhao, Zhen Hou, Bin Tang, Li Wang, Yaping Zhang, Yueqing Ying, Zhanzhuan Duo, Jie
Published in
International journal of experimental pathology
Autophagy has been implicated in the pathogenesis of various lung diseases. This study aimed to investigate the role of autophagy in lung injury induced by high-altitude hypoxia. Wistar rats were randomized into four groups for exposure to normal altitude or high altitude for 1, 7, 14 and 21 days with no treatment or with the treatment of 1 mg/kg r...
Luo, Yi Li, Tinghao Zhao, Hengguang Chen, Aijun
Published in
Molecular medicine reports
Hypoxia‑related long non‑coding RNAs (lncRNAs) are important indicators of the poor prognosis of cancers. The present study aimed to explore the potential relationship between melanoma and hypoxia‑related lncRNAs. The transcriptome and clinical data of patients with melanoma were downloaded from The Cancer Genome Atlas database. The prognostic hypo...
Statsenko, Yauhen Habuza, Tetiana Talako, Tatsiana Pazniak, Mikalai Likhorad, Elena Pazniak, Aleh Beliakouski, Pavel Gelovani, Juri G. Gorkom, Klaus Neidl-Van Almansoori, Taleb M.
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Published in
Frontiers in Medicine
Background Hypoxia is a potentially life-threatening condition that can be seen in pneumonia patients. Objective We aimed to develop and test an automatic assessment of lung impairment in COVID-19 associated pneumonia with machine learning regression models that predict markers of respiratory and cardiovascular functioning from radiograms and lung ...
Guo, Mengyuan Ji, Xunming Liu, Jia
Published in
Frontiers in Aging Neuroscience
Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease, with typical motor symptoms as the main clinical manifestations. At present, there are about 10 million patients with PD in the world, and its comorbidities and complications are numerous and incurable. Therefore, it is particularly important to ...
Li, Wenjin Yuan, Peng Liu, Weiqin Xiao, Lichan Xu, Chun Mo, Qiuyu Xu, Shujuan He, Yuchan Jiang, Duanfeng Wang, Xiaotao
...
Published in
Frontiers in Immunology
Background Multiple myeloma (MM) remains an incurable malignant tumor of plasma cells. Increasing evidence has reported that hypoxia and immune status contribute to the progression of MM. In this research, the prognostic value of the hypoxia–immune-related gene SLC19A1 in MM was evaluated by bioinformatics analysis. Method RNA-sequencing (RNA-seq) ...
