Published in Current eye research
To determine the expression of hypoxia-induced factor-1α (HIF-1α) and its downstream factors in human Tenon's capsule fibroblasts (HTFs) and changes in HTFs biological functions, we explored the role of HIF-1α in HTFs under hypoxia to provide a basis for studying the regulation of HIF-1α in wound healing after glaucoma surgery. we established HTFs ...
Population genomic studies of humans and other animals at high altitude have generated many hypotheses about the genes and pathways that may have contributed to hypoxia adaptation. Future advances require experimental tests of such hypotheses to identify causal mechanisms. Studies to date illustrate the challenge of moving from lists of candidate g...
Published in Critical Care Explorations
To determine the association between prone positioning in nonintubated patients with coronavirus disease 2019 and frequency of invasive mechanical ventilation or inhospital mortality. Design: A nested case-matched control analysis. Setting: Three hospital sites in Bronx, NY. Patients: Adult coronavirus disease 2019 patients admitted between March 1...
Published in Magnesium research
Published in American journal of physiology. Lung cellular and molecular physiology
Severe asthma is a chronic airway disease that exhibits poor response to conventional asthma therapies. Growing evidence suggests that elevated hypoxia increases the severity of asthmatic inflammation among patients and in model systems. In this study, we elucidate the therapeutic effects and mechanistic basis of Adhatoda Vasica (AV) aqueous extrac...
Published in Frontiers in Plant Science
Flooding induces low oxygen (hypoxia) stress to plants, and this scenario is mounting due to hurricanes followed by heavy rains, especially in subtropical regions. Hypoxia stress results in the reduction of green pigments, gas exchange (stomatal conductance and internal CO2 concentration), and photosynthetic activity in the plant leaves. In additio...
Published in Frontiers in Physiology
Background Hypoxia-induced decline in exercise capacity is ubiquitous among lowlanders who immigrated to high altitudes, which severely reduces their work efficiency and quality of life. Although studies have revealed that hypoxia-induced cardiovascular dysfunction limits exercise capacity at high altitudes, the mechanisms have not been well explor...
Published in Journal of Tissue Engineering
This study investigates the transcriptome response of meniscus fibrochondrocytes (MFCs) to the low oxygen and mechanical loading signals experienced in the knee joint using a model system. We hypothesized that short term exposure to the combined treatment would promote a matrix-forming phenotype supportive of inner meniscus tissue formation. Human ...
Published in Journal of Biosciences
Hypoxia plays an important role in many heart diseases. MicroRNA-9 (miR-9) has been reported to be involved in hypoxia-induced cell proliferation, injury and apoptosis in cardiomyocytes. However, the underlying mechanism still remains poorly understood. The expression levels of miR-9 and cyclin-dependent kinase 8 (CDK8) were detected by quantitativ...
Published in Stem Cell Reports
H. Huerga Encabo and colleagues demonstrate that SARS-CoV-2 can infect erythroid progenitors without impairing their functionality, rather causing an expansion of colonies where the virus can be detected. These findings shed light into the patients with severe COVID-19 who suffer from an aberrant increase of nucleated red blood cells concomitant wi...
