Crane, Jason C Gordon, Jeremy W Chen, Hsin-Yu Autry, Adam W Li, Yan Olson, Marram P Kurhanewicz, John Vigneron, Daniel B Larson, Peder E Z Xu, Duan
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Published in
NMR in biomedicine
Based on the expanding set of applications for hyperpolarized carbon-13 (HP-13 C) MRI, this work aims to communicate standardized methodology implemented at the University of California, San Francisco, as a primer for conducting reproducible metabolic imaging studies of the prostate and brain. Current state-of-the-art HP-13 C acquisition, data proc...
Hahn, Andrew D Kammerman, Jeff Fain, Sean B
Published in
Magnetic resonance in medicine
A novel technique is presented for retrospective estimation and removal of gas-phase hyperpolarized Xenon-129 (HP 129 Xe) from images of HP 129 Xe dissolved in the barrier (comprised of parenchymal lung tissue and blood plasma) and red blood cell (RBC) phases. The primary aim is mitigating RF pulse performance limitations on measures of gas exchang...
Larson, Peder E. Z. Chen, Hsin-Yu Gordon, Jeremy W. Korn, Natalie Maidens, John Arcak, Murat Tang, Shuyu Criekinge, Mark Carvajal, Lucas Mammoli, Daniele
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Published in
NMR in biomedicine
MRI using hyperpolarized (HP) carbon-13 pyruvate is being investigated in clinical trials to provide non-invasive measurements of metabolism for cancer and cardiac imaging. In this project, we applied HP [1-13C]pyruvate dynamic MRI in prostate cancer to measure the conversion from pyruvate to lactate, which is expected to increase in aggressive can...
Daniels, Charlotte Gallagher, Ferdia
Hyperpolarized MRI with 13C-labelled compounds is an emerging clinical technique allowing in vivo metabolic processes to be characterized non-invasively. Accurate quantification of 13C data, both for clinical and research purposes, typically relies on the use of region-of-interest analysis to detect and compare regions of altered metabolism. Howeve...
Leary, Del Svenningsen, Sarah Guo, Fumin Bhatawadekar, Swati Parraga, Grace Maksym, Geoffrey N
Published in
Physiological reports
In patients with asthma, magnetic resonance imaging (MRI) provides direct measurements of regional ventilation heterogeneity, the etiology of which is not well-understood, nor is the relationship of ventilation abnormalities with lung mechanics. In addition, respiratory resistance and reactance are often abnormal in asthmatics and the frequency dep...
Hartley, Ruth Baldi, Simonetta Brightling, Chris Gupta, Sumit
Published in
Expert review of clinical immunology
Currently, imaging in asthma is confined to chest radiography and CT. The emergence of new imaging techniques and tremendous improvement of existing imaging methods, primarily due to technological advancement, has completely changed its research and clinical prospects. In research, imaging in asthma is now being employed to provide quantitative ass...
Matsumoto, Shingo Yasui, Hironobu Batra, Sonny Kinoshita, Yuichi Bernardo, Marcelino Munasinghe, Jeeva P Utsumi, Hideo Choudhuri, Rajani Devasahayam, Nallathamby Subramanian, Sankaran
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Published in
Proceedings of the National Academy of Sciences of the United States of America
Architectural and functional abnormalities of blood vessels are a common feature in tumors. A consequence of increased vascular permeability and concomitant aberrant blood flow is poor delivery of oxygen and drugs, which is associated with treatment resistance. In the present study, we describe a strategy to simultaneously visualize tissue oxygen c...
