Obońska, Karolina Kasprzak, Michał Tymosiak, Kamila Fabiszak, Tomasz Krintus, Magdalena Kubica, Jacek
Published in
Cardiology journal
In an attempt to improve low density lipoprotein-cholesterol (LDL-C) level control in patients ineffectively treated with statins, we evaluated the effectiveness of a fixed-dose combination (FDC) of 10 mg rosuvastatin and ezetimibe and its relation to the timing of drug administration. A randomized, open label, single center, crossover study involv...
Kosmas, Constantine E Muñoz Estrella, Alba Skavdis, Andreas Peña Genao, Edilberto Martinez, Ian Guzman, Eliscer
Published in
Therapeutics and Clinical Risk Management
Proprotein convertase subtilisin kexin 9 (PCSK-9)-targeting therapy has arisen as a new line for the treatment of hyperlipidemia. Inclisiran is a double-stranded small RNA molecule that works by blocking the transcription of PCSK-9, leading to a reduction of PCSK9 levels in the hepatocytes, resulting in an increased expression of low-density lipopr...
Kim, You-Jin Oh, Se-Hyun Ahn, Ji-Sun Yook, Ju-Min Kim, Chan-Duck Park, Sun-Hee Cho, Jang-Hee Kim, Yong-Lim
Published in
International Journal of Molecular Sciences
In the present study, we investigated the effects of xanthine oxidase (XO) inhibition on cholesterol-induced renal dysfunction in chronic kidney disease (CKD) mice, and in low-density lipoprotein (LDL)-treated human kidney proximal tubule epithelial (HK-2) cells. ApoE knockout (KO) mice underwent uninephrectomy to induce CKD, and were fed a normal ...
Duprez, Daniel A Handelsman, Yehuda Koren, Michael
Published in
Vascular Health and Risk Management
Cardiovascular (CV) disease remains the leading cause of morbidity and mortality worldwide and poses an ongoing challenge with the aging population. Elevated low-density lipoprotein cholesterol (LDL-C) is an established risk factor for atherosclerotic cardiovascular disease (ASCVD), and the expert consensus is the use of statin therapy (if tolerate...
López-Bautista, Fabiola Posadas-Sánchez, Rosalinda Vázquez-Vázquez, Christian Fragoso, José Manuel Rodríguez-Pérez, José Manuel Vargas-Alarcón, Gilberto
Published in
Biomolecules
Interleukin 37 ( IL-37 ) is an anti-inflammatory cytokine involved in the regulation of cholesterol homeostasis, reducing the levels of plasma cholesterol, fatty acids, and triglycerides. The aim of the present study was to evaluate the association of the IL-37 polymorphisms with the presence of hypercholesterolemia (HC), and with cardiovascular ri...
Trinder, Mark Paquette, Martine Cermakova, Lubomira Ban, Matthew R Hegele, Robert A Baass, Alexis Brunham, Liam R
Published in
Circulation. Genomic and precision medicine
Familial hypercholesterolemia (FH) is a common autosomal codominant genetic disorder, which causes elevated levels of low-density lipoprotein cholesterol (LDL-C) and increased risk of premature atherosclerotic cardiovascular disease (ASCVD). Even among individuals with monogenic FH, there is substantial interindividual variability in LDL-C levels a...
Villalvilla, Amanda Larrañaga-Vera, Ane Lamuedra, Ana Pérez-Baos, Sandra López-Reyes, Alberto G. Herrero-Beaumont, Gabriel Largo, Raquel
Published in
Frontiers in Medicine
Objective: Several studies have linked metabolic syndrome to the development of osteoarthritis (OA) through hypercholesterolemia, one of its components. However, epidemiological studies showed contradictory results, and it is not clear how hypercholesterolemia itself, or oxidized LDL (oxLDL)—a pathological molecule potentially involved in this rela...
Gömöri, Kamilla Szabados, Tamara Kenyeres, Éva Pipis, Judit Földesi, Imre Siska, Andrea Dormán, György Ferdinandy, Péter Görbe, Anikó Bencsik, Péter
...
Published in
International Journal of Molecular Sciences
Background: We recently developed novel matrix metalloproteinase-2 (MMP-2) inhibitor small molecules for cardioprotection against ischemia/reperfusion injury and validated their efficacy in ischemia/reperfusion injury in cardiac myocytes. The aim of the present study was to test our lead compounds for cardioprotection in vivo in a rat model of acut...
Lin, Hung-Ju Yu, Sung-Liang Su, Ta-Chen Hsu, Hsiu-Ching Chen, Ming-Fong Lee, Yuan-Teh Chien, Kuo-Liong Lu, Tzu-Pin
Published in
Bioscience Reports
Statins inhibit cholesterol biogenesis and modulate atheroma inflammation to reduce cardiovascular risks. Promoted by immune and non-immune cells, serum C-reactive protein (CRP) might be a biomarker suboptimal to assess inflammation status. Although it has been reported that statins modulated inflammation via microRNAs (miRNAs), evidence remains la...
Xue, Xiaoxue Liu, Yijia Yang, Mingjie Wang, Shuo Huang, Mengnan Gao, Shuming Xu, Yilan Gao, Shan Li, Lin Yu, Chunquan
...
Published in
Medicine
Coronary heart disease (CHD) is the leading cause of death globally. Angina pectoris is closely associated with coronary artery insufficiency, which seriously affects the quality of life and work of patients. Hypercholesterolemia and hypertension (HTN) are risk factors for CHD angina pectoris. The correlation between hypercholesterolemia with or wi...
