Galan, Luis Enrique Bermejo dos Santos, Nayara Melo Asato, Mauro Shosuka Araújo, Jucineide Vieira de Lima Moreira, Adriana Araújo, Aléxia Mahara Marques Paiva, Artur Diogenes Pinheiro Portella, Diego Guilherme Santos Marques, Frank Silas Saldanha Silva, Gabriel Melo Alexandre
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Published in
Pathogens and Global Health
Objective : Given the urgent need for strategies to minimize the damage caused by this pandemic, this study performed a randomized, double-blind phase 2 study to assess the safety of the effectiveness of chloroquine (CQ), hydroxychloroquine (HCQ) or ivermectin in severe forms of COVID-19, in addition to identifying predictors of mortality in this g...
Vivanco-Hidalgo, Rosa Maria Molina, Israel Martinez, Elisenda Roman-Viñas, Ramón Sánchez-Montalvá, Adrián Fibla, Joan Pontes, Caridad Velasco Muñoz, César
Published in
Eurosurveillance
Background Several clinical trials have assessed the protective potential of chloroquine and hydroxychloroquine. Chronic exposure to such drugs might lower the risk of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or severe coronavirus disease (COVID-19). Aim To assess COVID-19 incidence and risk of hospitalisation in ...
Tanriverdİ, Elif Çörtük, Mustafa Yildirim, Binnaz Zeynep Uğur Chousein, Efsun Gonca Turan, Demet Çinarka, Halit Özgül, Mehmet Akif Çetinkaya, Erdoğan
Published in
Turkish journal of medical sciences
New treatment regimens for COVID-19, which has threatened the world recently, continue to be investigated. Although some of the treatments are promising, it is thought to be early to state that there is definitive treatment. Experiences and treatment protocol studies from treatment centers are still important. The aim of this study is to evaluate f...
Bae, Seongman Ghang, Byeongzu Kim, Ye-Jee Lim, Joon Seo Yun, Sung-Cheol Kim, Yong-Gil Lee, Sang-Oh Kim, Sung-Han
Published in
Viruses
To evaluate the role of hydroxychloroquine (HCQ) as pre-exposure prophylaxis against coronavirus disease 2019 (COVID-19), we investigated the prevalence of positive test results for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing according to recent HCQ use in patients who had been tested using nationwide health-insurance data ...
Awad, Nirvana Schiller, Daryl S Fulman, Magda Chak, Azfar
Published in
American Journal of Health-System Pharmacy: AJHP
Disclaimer In an effort to expedite the publication of articles related to the COVID-19 pandemic, AJHP is posting these manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final versi...
Abdallah, Ghada E M Elbiih, Esam A S Sayed, Douaa Moeen, Sawsan M Gafer, Shima Thabet, Ahmad F
Published in
Platelets
The balance between therapy effectiveness and economic efficiency in chronic immune thrombocytopenia (ITP) becomes more confusing. This single-center open label randomized controlled trial evaluates the effectiveness and safety of hydroxychloroquine in chronic ITP patients against other affordable second-line treatments. It is registered under numb...
Zhang, Miao Yao, Xueting Hou, Zhe Guo, Xuan Tu, Siqi Lei, Zihan Yu, Zhiheng Liu, Xuanlin Cui, Cheng Chen, Xijing
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Published in
Frontiers in Pharmacology
In Feb 2020, we developed a physiologically-based pharmacokinetic (PBPK) model of hydroxychloroquine (HCQ) and integrated in vitro anti-viral effect to support dosing design of HCQ in the treatment of COVID-19 patients in China. This, along with emerging research and clinical findings, supported broader uptake of HCQ as a potential treatment for CO...
Bignardi, Paulo Roberto Vengrus, Carolina Santos Aquino, Bruno Matos Cerci Neto, Alcindo
Published in
Pathogens and global health
COVID-19 has quickly become a public health problem worldwide, and treatment for this new disease is needed. Hydroxychloroquine is an antimalarial that in vitro studies have shown action against SARS-CoV-2, which is why it has been the target of clinical studies with conflicting results. Therefore, the aim of this systematic review was to assess th...
Halcrow, Peter W. Geiger, Jonathan D. Chen, Xuesong
Published in
Frontiers in Cell and Developmental Biology
Resistance to the anti-cancer effects of chemotherapeutic agents (chemoresistance) is a major issue for people living with cancer and their providers. A diverse set of cellular and inter-organellar signaling changes have been implicated in chemoresistance, but it is still unclear what processes lead to chemoresistance and effective strategies to ov...
Sawalha, Amr H
Published in
Annals of the rheumatic diseases
