Austin, Mark Burschowsky, Daniel Chan, Denice T.Y. Jenkinson, Lesley Haynes, Stuart Diamandakis, Agata Seewooruthun, Chitra Addyman, Alexandra Fiedler, Sebastian Ryman, Stephanie
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Published in
mAbs
Arginase 2 (ARG2) is a binuclear manganese metalloenzyme that catalyzes the hydrolysis of L-arginine. The dysregulated expression of ARG2 within specific tumor microenvironments generates an immunosuppressive niche that effectively renders the tumor ‘invisible’ to the host’s immune system. Increased ARG2 expression leads to a concomitant depletion ...
Giles, April R. Calcedo, Roberto Tretiakova, Anna P. Wilson, James M.
Published in
Frontiers in Immunology
With the advent of single B-cell cloning technology, we can isolate antibodies against virtually any antigen to study the interaction of a given pathogen with the immune system and develop novel therapeutic strategies. Antibodies directed against the capsid of adeno-associated viruses (AAV) are a significant obstacle to effectively leveraging AAV a...
BalcioĞlu, Bertan Koray Denİzcİ ÖncÜ, Melis ÖztÜrk, Hasan Ümit YÜcel, Fatıma Kaya, Filiz Serhatli, Müge ÜlbeĞİ Polat, Hivda Tekİn, Şaban Özdemİr Bahadir, Aylin
Published in
Turkish journal of biology = Turk biyoloji dergisi
In December 2019 a novel coronavirus was detected in Wuhan City of Hubei Province-China. Owing to a high rate of transmission from human to human, the new virus called SARS-CoV-2 differed from others by its unexpectedly rapid spread. The World Health Organization (WHO) described the most recent coronavirus epidemic as a global pandemic in March 202...
Yang, Hobin Park, Hayeon Lee, Yong Jin Choi, Jun Young Kim, TaeEun Rajasekaran, Nirmal Lee, Saehyung Song, Kyoung Hong, Sungyoul Choi, Joon-Seok
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Published in
Biomolecules
Most malignant tumors originate from epithelial tissues in which tight junctions mediate cell–cell interactions. Tight junction proteins, especially claudin-3 (CLDN3), are overexpressed in various cancers. Claudin-3 is exposed externally during tumorigenesis making it a potential biomarker and therapeutic target. However, the development of antibod...
Cerino, Antonella Mantovani, Stefania Mele, Dalila Oliviero, Barbara Varchetta, Stefania Mondelli, Mario U
Published in
Frontiers in immunology
Despite the availability of an effective prophylactic vaccine leading to sterilizing immunity, hepatitis B virus (HBV) is responsible for chronic liver disease in more than 250 million individuals, potentially leading to cirrhosis and hepatocellular carcinoma. Antiviral drugs able to completely suppress virus replication are indeed available but th...
Okuda, Moe Yamayoshi, Seiya Uraki, Ryuta Ito, Mutsumi Hamabata, Taiki Kawaoka, Yoshihiro
Published in
Viruses
Highly pathogenic avian H5 influenza viruses persist among poultry and wild birds throughout the world. They sometimes cause interspecies transmission between avian and mammalian hosts. H5 viruses possessing the HA of subclade 2.3.4.4, 2.3.2.1, 2.2.1, or 7.2 were detected between 2015 and 2018. To understand the neutralizing epitopes of H5-HA, we c...
Lee, Edward Gibbs, John P Emery, Maurice G Block, Geoffrey Wasserman, Scott M Hamilton, Lisa Kasichayanula, Sreeneeranj Hanafin, Patrick Somaratne, Ransi Egbuna, Ogo
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Published in
Clinical pharmacology in drug development
We evaluated the pharmacokinetics, pharmacodynamics, and safety of evolocumab, a fully human monoclonal antibody against proprotein convertase subtilisin kexin type 9 (PCSK9), in an open-label, parallel-design study in participants with normal renal function (n = 6), severe renal impairment (RI; n = 6), or end-stage renal disease (ESRD) receiving h...
Wang, Yang Esquivel, Rianne Flingai, Seleeke Schiller, Zachary A Kern, Aurélie Agarwal, Sangya Chu, Jacqueline Patel, Ami Sullivan, Katherine Wise, Megan C
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Published in
The Journal of infectious diseases
We recently developed anti-OspA human immunoglobulin G1 monoclonal antibodies (HuMAbs) that are effective in preventing Borrelia transmission from ticks in a murine model. Here, we investigated a novel approach of DNA-mediated gene transfer of HuMAbs that provide protection against Lyme disease. Plasmid DNA-encoded anti-OspA HuMAbs inoculated in mi...
Wang, Yang Esquivel, Rianne Flingai, Seleeke Schiller, Zachary A. Kern, Aurelie Agarwal, Sangya Chu, Jacqueline Patel, Ami Sullivan, Katherine Wise, Megan C.
...
We recently developed anti-OspA human immunoglobulin G1 monoclonal antibodies (HuMAbs) that are effective in preventing Borrelia transmission from ticks in a murine model. Here, we investigated a novel approach of DNA-mediated gene transfer of HuMAbs that provide protection against Lyme disease. Plasmid DNA-encoded anti-OspA HuMAbs inoculated in mi...
Niu, Peihua Zhang, Senyan Zhou, Panpan Huang, Baoying Deng, Yao Qin, Kun Wang, Pengfei Wang, Wenling Wang, Xinquan Zhou, Jianfang
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Published in
The Journal of infectious diseases
The Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory infection with a high (~35%) mortality rate. Neutralizing antibodies targeting the spike of MERS-CoV have been shown to be a therapeutic option for treatment of lethal disease. We describe the germline diversity and neutralizing activity of 13 potent human monoclo...