Is It Time for Sports and Health in the Era of Covid-19 Pandemic?
Published in International journal of environmental research and public health
When we took the initiative for this Special Issue, we were uncertain about its success [...].
Published in International journal of environmental research and public health
When we took the initiative for this Special Issue, we were uncertain about its success [...].
Published in Frontiers in Neurology
Background: Central nervous system (CNS) infection is associated with high rates of morbidity and mortality, and despite advancements in molecular testing, aseptic meningitis remains challenging to diagnose. Aseptic meningitis cases are often underreported worldwide, which impacts the quality of patient care. Therefore, we aimed to assess the resul...
Published in Viruses
Infections that are triggered by the accompanying immunosuppression in patients with burn wounds are very common regardless of age. Among burn patients, the most frequently diagnosed infections include the bacterial ones primarily caused by Pseudomonas aeruginosa or Klebsiella pneumonia , as well as fungal infections with the etiology of Candida sp...
Published in Viruses
Infectious laryngotracheitis virus (ILTV) is a herpes virus that causes an acute respiratory disease of poultry known as infectious laryngotracheitis (ILT). Chicken embryo origin (CEO) and tissue culture origin (TCO) live attenuated vaccines are routinely used for the control of ILT. However, vaccine virus is known to revert to virulence, and it ha...
Published in Frontiers in Microbiology
MicroRNAs (miRNAs) have been demonstrated for their involvement in virus biology and pathogenesis, including functioning as key determinants of virally-induced cancers. As an important oncogenic α-herpesvirus affecting poultry health, Marek’s disease virus serotype 1 [ Gallid alphaherpesvirus 2 (GaHV-2)] induces rapid-onset T-cell lymphomatous dise...
Published in Cell Reports
Gabaev et al. describe how a human oncogenic herpesvirus, KSHV, changes the proteome of endothelial cells and modulates the host immune system. By targeting KSHV with CRISPR, they show that viral K5 protein downregulates ligands for the NK cell DNAM-1 receptor and antiviral protein PKR is depleted in an K5-independent manner.
Published in Proceedings of the National Academy of Sciences of the United States of America
Viruses employ multiple strategies to inhibit host mRNA nuclear export. Distinct to the generally nonselective inhibition mechanisms, ORF10 from gammaherpesviruses inhibits mRNA export in a transcript-selective manner by interacting with Rae1 (RNA export 1) and Nup98 (nucleoporin 98). We now report the structure of ORF10 from MHV-68 (murine gammahe...
Published in Cell Reports
Soh et al. use quantitative mass spectrometry techniques to investigate how HSV-1 regulates the infected-cell proteome. They identify HSV-1 pUL56 as a ubiquitin ligase adaptor that promotes degradation of the cellular trafficking factor GOPC, lowering the abundance of immune signaling molecules on the surface of infected cells.
Published in Frontiers in Veterinary Science
Infectious and inflammatory processes are among the most common causes of central nervous system involvement in stranded cetaceans. Meningitis and encephalitis are among the leading known natural causes of death in stranded cetaceans and may be caused by a wide range of pathogens. This study describes histopathological findings in post-mortem brain...
Published in The Febs Journal
Pseudoenzymes are proteins that are evolutionarily related to active enzymes, but lack relevant catalytic activity. As obligate intracellular pathogens, viruses complete their life cycle fully dependent on the cellular supplies of macromolecule and energy. Traditionally, studies of viral proteins sharing high homology with host counterparts reveal ...