Viral Infections in the Intensive Care Unit
Published in Frontiers in Medicine
Role of Vesicle-Associated Membrane Protein-Associated Proteins (VAP) A and VAPB in Nuclear Egress of the Alphaherpesvir...
Published in Viruses
The molecular mechanism affecting translocation of newly synthesized herpesvirus nucleocapsids from the nucleus into the cytoplasm is still not fully understood. The viral nuclear egress complex (NEC) mediates budding at and scission from the inner nuclear membrane, but the NEC is not sufficient for efficient fusion of the primary virion envelope w...
Methods for the Manipulation of Herpesvirus Genome and the Application to Marek's Disease Virus Research.
Published in Microorganisms
Herpesviruses are a group of double-strand DNA viruses that infect a wide range of hosts, including humans and animals. In the past decades, numerous methods have been developed to manipulate herpesviruses genomes, from the introduction of random mutations to specific genome editing. The development of genome manipulation methods has largely advanc...
Maternal Epstein-Barr Virus-Specific Antibodies and Risk of Infection in Ugandan Infants.
...Published in The Journal of infectious diseases
Epstein-Barr virus (EBV) infection is a major cause of malignancy worldwide. Maternal antibody is thought to prevent EBV infection because it is uncommon in early infancy. Maternal HIV infection is associated with an increased incidence of EBV infection in exposed infants, which we hypothesized results from impaired transfer of EBV-neutralizing mat...
Efficacy and safety of bloodletting for herpes zoster
Published in Medicine
Background: The study aims to evaluate the effectiveness and safety of bloodletting therapy for herpes zoster. Methods: The following electronic databases will be searched from PubMed (1966 to March 2020), the Cochrane Central Register of Controlled Trials (update to March 2020), EMBASE (1980 to March 2020), China National Knowledge Infrastructure ...
KSHV Reprogramming of Host Energy Metabolism for Pathogenesis
Published in Frontiers in Cellular and Infection Microbiology
Reprogramming of energy metabolism is a key for cancer development. Kaposi’s sarcoma-associated herpesvirus (KSHV), a human oncogenic herpesvirus, is tightly associated with several human malignancies by infecting B-lymphocyte or endothelial cells. Cancer cell energy metabolism is mainly dominated by three pathways of central carbon metabolism, inc...
Intérêt du valganciclovir dans le traitement des infections à herpèsvirus équin 1 chez les équidés.
...
National audience
The Potential Role of Herpes Simplex Virus Type 1 and Neuroinflammation in the Pathogenesis of Alzheimer's Disease
Published in Frontiers in Neurology
Alzheimer's disease (AD) is a neurodegenerative disease affecting ~50 million people worldwide. To date, there is no cure and current therapies have not been effective in delaying disease progression. Therefore, there is an urgent need for better understanding of the pathogenesis of AD and to rethink possible therapies. Herpes simplex virus type 1 ...
Targeting Host Cellular Factors as a Strategy of Therapeutic Intervention for Herpesvirus Infections
Published in Frontiers in Cellular and Infection Microbiology
Herpesviruses utilize various host factors to establish latent infection, survival, and spread disease in the host. These factors include host cellular machinery, host proteins, gene expression, multiple transcription factors, cellular signal pathways, immune cell activation, transcription factors, cytokines, angiogenesis, invasion, and factors pro...
Intrahost speciations and host switches played an important role in the evolution of herpesviruses
Published in Virus Evolution
In times when herpesvirus genomic data were scarce, the cospeciation between these viruses and their hosts was considered to be common knowledge. However, as more herpesviral sequences were made available, tree reconciliation analyses started to reveal topological incongruences between host and viral phylogenies, indicating that other cophylogeneti...
