Yang, Yuangui Zhao, Yanli Zuo, Zhitian Zhang, Ji Shi, Yao Wang, Yuanzhong
Published in
Molecules
Secoiridoids could be used as a potential new drug for the treatment of hepatic disease. The content of secoiridoids of G. rigescens varied in different geographical origins and parts. In this study, a total of 783 samples collected from different parts of G. rigescens in Yunnan, Sichuan, and Guizhou Provinces. The content of secoiridoids including...
Fernandes, Bruno Dias, Emanuel Mascarenhas-Saraiva, Miguel Bernardes, Miguel Costa, Lúcia Cardoso, Hélder Macedo, Guilherme
Published in
Annals of gastroenterology
The course of hepatic diseases may be complicated by a multitude of rheumatologic manifestations, which can complicate the diagnostic approach and alter the natural history of primary liver disease, sometimes worsening prognosis due to associated multiple organ dysfunction. These manifestations can occur in association with a multitude of liver dis...
Trepotec, Zeljka Lichtenegger, Eva Plank, Christian Aneja, Manish K Rudolph, Carsten
Published in
Molecular therapy : the journal of the American Society of Gene Therapy
Promising improvements in the field of transcript therapeutics have clearly enhanced the potential of mRNA as a new pillar for protein replacement therapies. Synthetic mRNAs are engineered to replace mutated mRNAs and to be immunologically inconspicuous and highly stable while maximizing protein expression. Approaches to deliver mRNA into the cellu...
Prieto-Domínguez, Nestor Garcia-Mediavilla, Maria V Sanchez-Campos, Sonia Mauriz, Jose L Gonzalez-Gallego, Javier
Published in
Current medicinal chemistry
Autophagy is a cellular pathway with the ability to maintain cell homeostasis through the elimination of damaged or useless cellular components, and its deregulation may initiate or aggravate different human diseases. Flavonoids, a group of plant metabolites, are able to modulate different molecular and cellular processes including autophagy. To re...
Ramaswamy, Suvasini Tonnu, Nina Tachikawa, Kiyoshi Limphong, Pattraranee Vega, Jerel B Karmali, Priya P Chivukula, Pad Verma, Inder M
Published in
Proceedings of the National Academy of Sciences of the United States of America
Safe and efficient delivery of messenger RNAs for protein replacement therapies offers great promise but remains challenging. In this report, we demonstrate systemic, in vivo, nonviral mRNA delivery through lipid nanoparticles (LNPs) to treat a Factor IX (FIX)-deficient mouse model of hemophilia B. Delivery of human FIX (hFIX) mRNA encapsulated in ...
Uhl, Philipp Fricker, Gert Haberkorn, Uwe Mier, Walter
Published in
International journal of molecular sciences
Hepatic diseases, like viral hepatitis, autoimmune hepatitis, hereditary hemochromatosis, non-alcoholic fatty liver disease (NAFLD) and Wilson's disease, play an important role in the development of liver cirrhosis and, hence, hepatocellular carcinoma. In this review, the current treatment options and the molecular mechanisms of action of the drugs...
Vyshtakalyuk, A. B. Nazarov, N. G. Zueva, I. V. Lantsova, A. V. Minnekhanova, O. A. Busygin, D. V. Porfiryev, A. G. Evtyugin, V. G. Reznik, V. S. Zobov, V. V.
...
Published in
Bulletin of Experimental Biology and Medicine
Xymedon (1-(β-oxyethyl)-4,6-dimethyl-1,2-dihydro-2-oxopyrimidine), a regeneratory and wound-healing drug, exhibited hepatoprotective activity in laboratory animals with experimental toxic hepatitis. Oral drug reduced the severity of toxic involvement of the liver induced by CCl4 and reduced animal mortality. Xymedon promoted recovery of the blood b...
Govindarajan, Rajgopal Endres, Christopher J Whittington, Dale LeCluyse, Edward Pastor-Anglada, Marçal Tse, Chung-Ming Unadkat, Jashvant D
Published in
American journal of physiology. Gastrointestinal and liver physiology
We previously reported that both the concentrative (hCNT) and equilibrative (hENT) nucleoside transporters are expressed in the human liver (21). Here we report a study that investigated the expression of these transporters (transcripts and proteins) and their role in the hepatobiliary transport of nucleosides/nucleoside drugs using sandwich-cultur...
Sun, Wei He, Fuchu
Published in
Science in China Series C: Life Sciences
Proteomics has become an important part in the leading research area and been widely used in the disease-associated study. In hepatic research field, proteomics could be applied in study of hepatic diseases including liver cancer, cirrhosis and hepatotoxicities, etc. Significant proteins could be identified as biomarkers, drug targets and clues for...
