Direct TLR2 Signaling Through mTOR and TBK1 Induces C/EBPβ and IRF7-Dependent Macrophage Differentiation in Hematopoieti...
Published in Stem cells (Dayton, Ohio)
During an infection, hematopoiesis is altered to increase the output of mature myeloid cells to fight off the pathogen. Despite convincing evidence that hematopoietic stem and progenitor cells (HSPCs) can sense pathogens directly, more mechanistic studies are needed to reveal whether pattern recognition receptor (PRR) signaling initiates myeloid de...
