Zhang, Xixia Yang, Jing
Published in
Frontiers in Cell and Developmental Biology
Head and neck cancers (HNCs) rank as the sixth common and the seventh leading cause of cancer-related death worldwide, with an estimated incidence of 600,000 cases and 40–50% mortality rate every year. Radiotherapy is a common local therapeutic modality for HNC mainly through the function of ionizing radiation, with approximately 60% of patients tr...
Driessen, Daphne A. J. J. Dijkema, Tim Weijs, Willem L. J. Takes, Robert P. Pegge, Sjoert A. H. Zámecnik, Patrik van Engen-van Grunsven, Adriana C. H. Scheenen, Tom W. J. Kaanders, Johannes H. A. M.
Published in
Frontiers in Oncology
In head and neck cancer, the presence of nodal disease is a strong determinant of prognosis and treatment. Despite the use of modern multimodality diagnostic imaging, the prevalence of occult nodal metastases is relatively high. This is why in clinically node negative head and neck cancer the lymphatics are treated “electively” to eradicate subclin...
Powrózek, Tomasz Dziwota, Joanna Małecka-Massalska, Teresa
Published in
Journal of clinical medicine
Nutritional deficiencies (malnutrition, cachexia, sarcopenia, and unfavorable changes in the body composition) developing as a side effect of radiotherapy (RT) currently represents a significant but still inaccurately studied clinical problem in cancer patients. The incidence of malnutrition observed in head and neck cancer (HNC) patients in oncolo...
Qian, Jack M. Schoenfeld, Jonathan D.
Published in
Frontiers in Oncology
Immune checkpoint inhibitors (ICI) have revolutionized cancer treatment over the past decade. However, although the immune landscape suggests a strong rationale for the use of these agents in patients with head and neck squamous cell carcinoma, the available clinical evidence indicates that most patients currently do not respond to ICI monotherapy....
Lin, Kuan-Yin Cheng, Hui-Ching Yen, Chia-Jui Hung, Ching-Hsia Huang, Yu-Ting Yang, Hsin-Lun Cheng, Wan-Ting Tsai, Kun-Ling
Published in
International Journal of Environmental Research and Public Health
Background: Cisplatin administration may induce muscle atrophy, thereby reducing the fitness level of patients with head and neck cancer (HNC). To date, only animal studies have been conducted to test the effectiveness of exercise interventions in diminishing side effects of cisplatin. Aim: To determine whether exercise training improves physical f...
Zheng, Zhuangzhuang Zhao, Xin Zhao, Qin Zhang, Yuyu Liu, Shiyu Liu, Zijing Meng, Lingbin Xin, Ying Jiang, Xin
Published in
Frontiers in Oncology
Radiation-induced oral mucositis (RIOM) is a common side effect after radiotherapy (RT) in head and neck cancer (HNC) patients. RIOM patients with severe pain have difficulty in eating, which increases the incidence of malnutrition and affects patients’ quality of life and the process of RT. The mechanism of RIOM is not fully understood, and inflam...
Riva, Giuseppe Albano, Camilla Gugliesi, Francesca Pasquero, Selina Pacheco, Sergio Fernando Castillo Pecorari, Giancarlo Landolfo, Santo Biolatti, Matteo Dell'Oste, Valentina
Published in
International journal of molecular sciences
Besides smoking and alcohol, human papillomavirus (HPV) is a factor promoting head and neck squamous cell carcinoma (HNSCC). In some human tumors, including HNSCC, a number of mutations are caused by aberrantly activated DNA-modifying enzymes, such as the apolipoprotein B mRNA editing enzyme catalytic polypeptide-like (APOBEC) family of cytidine de...
Rong, Chao Zhou, Ran Wan, Shan Su, Dan Wang, Shou-Li Hess, Jochen
Published in
Frontiers in Oncology
Ubiquitin C-terminal hydrolases (UCHs), a subfamily of deubiquitinating enzymes (DUBs), have been found in a variety of tumor entities and play distinct roles in the pathogenesis and development of various cancers including head and neck cancer (HNC). HNC is a heterogeneous disease arising from the mucosal epithelia of the upper aerodigestive tract...
Liang, Jingou Yang, Bina Zhou, Xuedong Han, Qi Zou, Jing Cheng, Lei
Published in
Drug Delivery
Head and neck cancer (HNC) is among the most common malignancy that has a profound impact on human health and life quality. The treatment for HNC, especially for the advanced cancer is stage-dependent and in need of combined therapies. Various forms of adjuvant treatments such as chemotherapy, phototherapy, hyperthermia, gene therapy have been incl...
Serex, Charles-Arnaud Dulguerov, Nicolas
Published in
BMJ Case Reports
We report the case of an 84-year-old male patient suffering from a gastrointestinal stromal tumour (GIST) of the rectum who was referred to our ENT (Ear-Nose-Throat) clinic for a rapidly progressive stridor, aphagia and dysphonia. The clinical examination revealed a mass arising from the posterior wall of the pharynx, which obstructed the laryngeal...
