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Ni, Dongchun Lu, Xuhang Stahlberg, Henning Ekundayo, Babatunde
Short prokaryotic argonaute (pAgo) and toll/interleukin-1 receptor/resistance protein (TIR)-analog of PAZ (APAZ) form a heterodimeric SPARTA complex that provides immunity to its prokaryotic host through an abortive infection mechanism. Monomeric SPARTA senses foreign RNA/DNA duplexes to assemble an active tetramer resulting in cell death by nicoti...
Swarts, D.C. Makarova, K. Wang, Y. Nakanishi, K. Ketting, R.F. Koonin, E.V. Patel, D.J. van der Oost, J.
Argonaute proteins are conserved throughout all domains of life. Recently characterized prokaryotic Argonaute proteins (pAgos) participate in host defense by DNA interference, whereas eukaryotic Argonaute proteins (eAgos) control a wide range of processes by RNA interference. Here we review molecular mechanisms of guide and target binding by Argona...
