Santiago-Silva, Kaio Maciel de Bortoleti, Bruna Taciane da Silva Brito, Tiago de Oliveira Costa, Ivete Conchon Lima, Camilo Henrique da Silva Macedo, Fernando Jr Miranda-Sapla, Milena Menegazzo Pavanelli, Wander Rogério Bispo, Marcelle de Lima Ferreira
Published in
Journal of biomolecular structure & dynamics
In this report, we describe the synthesis and evaluation of nine N1,N2-disubstituted-benzoylguanidines against promastigotes and amastigotes forms of Leishmania amazonensis. The derivatives 2g and 2i showed low IC50 values against promastigote form (90.8 ± 0.05 µM and 68.4 ± 0.03 µM, respectively), low cytotoxicity profile (CC50 396 ± 0.02 µM and 8...
Oborina, E. N. Adamovich, S. N.
Published in
Russian Journal of General Chemistry
AbstractNew functionalized silatranes were synthesized by the reaction of 3-aminopropylsilatrane with urea, thiourea, guanidine, acetamide, acetylguanidine, and aminoguanidine. These silatranes were used to modify silica gel. The sorption activity of the modified silica gel towards the ions of the rare-earth elements Ce3+ and Tb3+ was studied.
toscani;, anita
Current therapy against herpes simplex viruses (HSV) relies on the use of a few nucleoside antivirals such as acyclovir, famciclovir and valacyclovir. However, the current drugs are ineffective against latent and drug-resistant HSV infections. A series of amidinourea compounds, designed as analogues of the antiviral drug moroxydine, has been synthe...
Lohmeyer, Lukas Kaifer, Elisabeth Enders, Markus Himmel, Hans‐Jörg
Published in
Chemistry (Weinheim an Der Bergstrasse, Germany)
The substitution of the methyl groups of acetylacetonato (acac) co‐ligands in a cobalt(II) complex with a redox‐active bisguanidine ligand by trifluoromethyl groups (hfacac co‐ligands) changes the redox properties. One‐electron oxidation of the complexes with acac co‐ligands is metal centered (Co(II)→Co(III)). By contrast, a radical monocationic bi...
Khan, P. R. Alugubelli, G. R. Sireesha, R. Deepti, K. Rao, P. V. Rao, M. V. B.
Published in
Russian Journal of General Chemistry
AbstractA microwave assisted novel domino synthetic approach to trifluoromethyl substituted imidazo[1,2-a]pyrimidin-5(1H)-one derivatives has been developed via a multi component cascade strategy in a single operation. The synthesized compounds can find application as structural components of biologically active compounds.
Tassoulas, Lambros J. Robinson, Ashley Martinez-Vaz, Betsy Aukema, Kelly G. Wackett, Lawrence P.
Published in
Applied and Environmental Microbiology
The widely prescribed pharmaceutical metformin and its main metabolite, guanylurea, are currently two of the most common contaminants in surface and wastewater. Guanylurea often accumulates and is poorly, if at all, biodegraded in wastewater treatment plants. This study describes Pseudomonas mendocina strain GU, isolated from a municipal wastewater...
Lohmeyer, Lukas Schön, Florian Kaifer, Elisabeth Himmel, Hans‐Jörg
Published in
Angewandte Chemie (International Ed. in English)
The strengthening of interligand hydrogen bonding triggers a redox‐induced intramolecular electron transfer (RIET) upon oxidation of a CoIII complex with a neutral redox‐active bisguanidine ligand, leading to metal reduction (CoIII→CoII) and two‐electron oxidation of the bisguanidine ligand. In the absence of interligand hydrogen bonding, oxidation...
Petrova, Olga V. Budaev, Arsalan B. Sagitova, Elena F. Ushakov, Igor A. Sobenina, Lyubov N. Ivanov, Andrey V. Trofimov, Boris A.
Published in
Molecules
An efficient method for the synthesis of pharmaceutically prospective pyrrole–aminopyrimidine ensembles (in up to 91% yield) by the cyclocondensation of easily available acylethynylpyrroles with guanidine nitrate has been developed. The reaction proceeds under heating (110–115 °C, 4 h) in the KOH/DMSO system. In the case of 2-benzoylethynylpyrrole,...
Wang, Yongtao Lu, Rui Yao, Jia Li, Haoran
Published in
Angewandte Chemie (International ed. in English)
The critical role of double hydrogen bonds was addressed for the aerobic α-hydroxylation of ketones catalyzed by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD), in the absence of either a metal catalyst or phosphine reductant. Experimental and theoretical investigations were performed to study the mechanism. In addition to initiating the reaction by pro...
osadchuk;, irina
The complexation of (3aR,7aR)-N-(3,5-bis(trifluoromethyl)phenyl)octahydro-2H-benzo[d]imidazol-2-imine (BTI), as a guest, to ethane-bridged bis(zinc octaethylporphyrin), bis(ZnOEP), as a host, has been studied by means of ultraviolet-visible (UV-Vis) and circular dichroism (CD) absorption spectroscopies, single crystal X-ray diffraction, and computa...
