Wawrzyniak, Marcin Morsy, Yasser Mladenov, Radoslav Tontodonati, Giulia Turgay, Yagmur Herwig, Stefan Back, Jonathan Mally, Manuela Faridmoayer, Amirreza Scharl, Michael
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Published in
Journal of Crohn's & colitis
Antibodies targeting tumor necrosis factor-alpha [TNF-alpha] are a mainstay in the treatment of inflammatory bowel disease. However, they fail to demonstrate efficacy in a considerable proportion of patients. On the other hand, glycosylation of antibodies might influence not only their immunogenicity but also their structure and function. We invest...
Hou, Haifeng Yang, Huan Liu, Pengcheng Huang, Changwu Wang, Meng Li, Yuejin Zhu, Mingsong Wang, Jing Xu, Yuan Wang, Youxin
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Published in
Frontiers in Immunology
Coronavirus disease 2019 (COVID-19) remains a major health challenge globally. Previous studies have suggested that changes in the glycosylation of IgG are closely associated with the severity of COVID-19. This study aimed to compare the profiles of IgG N -glycome between COVID-19 patients and healthy controls. A case-control study was conducted, i...
Sumya, Farhana Taher Pokrovskaya, Irina D. Lupashin, Vladimir
Published in
Frontiers in Genetics
Conserved Oligomeric Golgi (COG) is an octameric protein complex that orchestrates intra-Golgi trafficking of glycosylation enzymes. Over a hundred individuals with 31 different COG mutations have been identified until now. The cellular phenotypes and clinical presentations of COG-CDGs are heterogeneous, and patients primarily represent neurologica...
Ouchida, Tsunenori Takamatsu, Shinji Maeda, Megumi Asuka, Tatsuya Morita, Chiharu Kondo, Jumpei Ueda, Keiji Miyoshi, Eiji
Published in
Viruses
Hepatitis B virus (HBV) is a major pathogen that causes acute/chronic hepatitis. Continuous HBV infection can lead to the development of hepatocellular carcinoma (HCC). Although several different anti-HBV treatments are available for chronic hepatitis B patients, discontinuing these medications is difficult. Patients with chronic hepatitis B at hig...
tezuka, daisuke matsuura, hideyuki saburi, wataru mori, haruhide imai, ryozo
Salicylic acid (SA) is a phytohormone that regulates a variety of physiological and developmental processes, including disease resistance. SA is a key signaling component in the immune response of many plant species. However, the mechanism underlying SA-mediated immunity is obscure in rice (Oryza sativa). Prior analysis revealed a correlation betwe...
Liu, Dejian Xiao, Xuyao Zhou, Peng Zheng, Huijun Li, Yaqian Jin, Hui Jongkaewwattana, Anan Luo, Rui
Published in
Virulence
Duck Tembusu virus (DTMUV), an emergent flavivirus, causes domestic waterfowls to suffer from severe egg-drop syndrome and fatal encephalitis, greatly threatens duck production globally. Like other mosquito-borne flaviviruses, the envelope (E) protein of all DTMUV strains was N-glycosylated at the amino acid position 154. Thus far, the biological r...
Park, Julien H. Marquardt, Thorsten
Published in
Frontiers in Genetics
Despite advances in the identification and diagnosis of congenital disorders of glycosylation (CDG), treatment options remain limited and are often constrained to symptomatic management of disease manifestations. However, recent years have seen significant advances in treatment and novel therapies aimed both at the causative defect and secondary di...
González-Domínguez, Carlos Alberto Fiesco-Roa, Moisés O. Gómez-Carmona, Samuel Kleinert-Altamirano, Anke Paula Ingrid He, Miao Daniel, Earnest James Paul Raymond, Kimiyo M. Abreu-González, Melania Manrique-Hernández, Sandra González-Jaimes, Ana
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Published in
Frontiers in Genetics
This study reports on a Mexican mestizo patient with a multi-systemic syndrome including neurological involvement and a type I serum transferrin profile. Clinical exome sequencing revealed complex alleles in ALG1 , the encoding gene for the chitobiosyldiphosphodolichol beta-mannosyltransferase that participates in the formation of the dolichol-pyro...
Cvetko, Ana Mangino, Massimo Tijardović, Marko Kifer, Domagoj Falchi, Mario Keser, Toma Perola, Markus Spector, Tim D Lauc, Gordan Menni, Cristina
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Published in
BMJ open diabetes research & care
Prediction of type 2 diabetes mellitus (T2DM) and its preceding factors, such as insulin resistance (IR), is of great importance as it may allow delay or prevention of onset of the disease. Plasma protein N-glycome has emerged as a promising predictive biomarker. In a prospective longitudinal study, we included patients with a first diagnosis of im...
krawczyk-łebek, agnieszka dymarska, monika janeczko, tomasz kostrzewa-susłow, edyta
Flavonoids, including chalcones, are more stable and bioavailable in the form of glycosylated and methylated derivatives. The combined chemical and biotechnological methods can be applied to obtain such compounds. In the present study, 2′-hydroxy-2-methylchalcone was synthesized and biotransformed in the cultures of entomopathogenic filamentous fun...
