Yang, Fan Zhang, Fan Ji, Xueying Jiang, Xin Xue, Mengjuan Yu, Huiyuan Hu, Xiaona Bao, Zhijun
Published in
The Journal of biological chemistry
Adult progenitor cell populations typically exist in a quiescent state within a controlled niche environment. However, various stresses or forms of damage can disrupt this state, which often leads to dysfunction and aging. We built a glucocorticoid (GC)-induced liver damage model of mice, found that GC stress induced liver damage, leading to conseq...
Kadirvelraj, Renuka Yang, Jeong-Yeh Kim, Hyun Woo Sanders, Justin H Moremen, Kelley W Wood, Zachary A
Published in
The Journal of biological chemistry
Poly-N-acetyl-lactosamine (poly-LacNAc) structures are composed of repeating [-Galβ(1,4)-GlcNAcβ(1,3)-]n glycan extensions. They are found on both N- and O--glycoproteins and glycolipids, and play an important role in development, immune function, and human disease. The majority of mammalian poly-LacNAc is synthesized by the alternating iterative a...
Boson, Bertrand Legros, Vincent Zhou, Bingjie Siret, Eglantine Mathieu, Cyrille Cosset, François-Loïc Lavillette, Dimitri Denolly, Solène
Published in
The Journal of biological chemistry
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a β-coronavirus, is the causative agent of the COVID-19 pandemic. Like for other coronaviruses, its particles are composed of four structural proteins: Spike (S), Envelope (E), Membrane (M) and Nucleoprotein (N) proteins. The involvement of each of these proteins and their interactio...
Barb, Adam W
Published in
The Journal of biological chemistry
The antibody-binding crystallizable fragment (Fc) γ receptors (FcγRs) are expressed by leukocytes and activate or suppress a cellular response once engaged with an antibody-coated target. Therapeutic mAbs that require FcγR binding for therapeutic efficacy are now frontline treatments for multiple diseases. However, substantially fewer development e...
Kierlik, Patrycja Hanc-Kuczkowska, Aneta Rachwał, Marzena Męczyński, Ryszard Matuła, Izabela
Published in
Materials (Basel, Switzerland)
The main objective of the presented preliminary study was the identification of iron-containing phases. Iron-containing phases had accumulated in organic topsoil horizons collected from an area that has long been affected by the steel industry and emissions from power plants. X-ray diffraction and Mössbauer spectroscopy methods were used for the de...
Amitai, Assaf
Published in
bioRxiv : the preprint server for biology
The evolution of circulating viruses is shaped by their need to evade the adaptive immune system. The spike protein which mediates entry to the host cell is the main target of antibody response. Because of the dense presentation of spikes on the viral surface, not all antigenic sites are targeted equally by antibodies, leading to complex immunodomi...
Hils, Miriam Wölbing, Florian Hilger, Christiane Fischer, Jörg Hoffard, Nils Biedermann, Tilo
Published in
Frontiers in Immunology
Although first described decades ago, the relevance of carbohydrate specific antibodies as mediators of type I allergy had not been recognized until recently. Previously, allergen specific IgE antibodies binding to carbohydrate epitopes were considered to demonstrate a clinically irrelevant cross-reactivity. However, this changed following the disc...
Takadate, Yoshihiro Manzoor, Rashid Saito, Takeshi Kida, Yurie Maruyama, Junki Kondoh, Tatsunari Miyamoto, Hiroko Ogawa, Hirohito Kajihara, Masahiro Igarashi, Manabu
...
Published in
Microorganisms
Lloviu virus (LLOV), a bat-derived filovirus that is phylogenetically distinct from human pathogenic filoviruses such as Ebola virus (EBOV) and Marburg virus (MARV), was discovered in Europe. However, since infectious LLOV has never been isolated, the biological properties of this virus remain poorly understood. We found that vesicular stomatitis v...
Stevenson-Leggett, Phoebe Keep, Sarah Bickerton, Erica
Published in
Viruses
The Gammacoronavirus infectious bronchitis virus (IBV) causes a highly contagious and economically important respiratory disease in poultry. In the laboratory, most IBV strains are restricted to replication in ex vivo organ cultures or in ovo and do not replicate in cell culture, making the study of their basic virology difficult. Entry of IBV into...
Ströh, Luisa J. Krey, Thomas
Published in
International Journal of Molecular Sciences
Despite the approval of highly efficient direct-acting antivirals in the last decade Hepatitis C virus (HCV) remains a global health burden and the development of a vaccine would constitute an important step towards the control of HCV. The high genetic variability of the viral glycoproteins E1 and E2, which carry the main neutralizing determinants,...
