Dua, Tarun K Joardar, Swarnalata Chakraborty, Pratik Bhowmick, Shovonlal Saha, Achintya De Feo, Vincenzo Dewanjee, Saikat
Published in
Molecules (Basel, Switzerland)
The present study evaluated the therapeutic potential of myricitrin (Myr), a glycosyloxyflavone extracted from Myrica esculenta bark, against diabetic nephropathy. Myr exhibited a significant hypoglycemic effect in high fat-fed and a single low-dose streptozotocin-induced type 2 diabetic (T2D) rats. Myr was found to improve glucose uptake by the sk...
Wang, Xin-Pei Xing, Chang-Yang Zhang, Jia-Xin Zhou, Jia-Heng Li, Yun-Chu Yang, Hong-Yan Zhang, Peng-Fei Zhang, Wei Huang, Yin Long, Jian-Gang
...
Published in
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Dietary restriction has been well-described to improve health metrics, but whether it could benefit pathophysiological adaptation to extreme environment, for example, microgravity, remains unknown. Here, we investigated the effects of a daily rhythm of fasting and feeding without reducing caloric intake on cardiac function and metabolism against si...
Li, Ling-Yu Lv, Hong-Bo Jiang, Zhe-Yue Qiao, Fang Chen, Li-Qiao Zhang, Mei-Ling Du, Zhen-Yu
Published in
The Journal of physiology
The pparab subtype in zebrafish is much more highly expressed in tissues with high oxidative activity than pparaa. The pparab deficiency in zebrafish reduces fatty acid β-oxidation both in liver and muscle, illustrating its functional homology as a mammalian peroxisome proliferator-activated receptor α (PPARα). pparab deficiency promotes metabolic ...
Badoer, Emilio
Published in
Frontiers in Physiology
The carotid body is a highly vascularized organ designed to monitor oxygen levels. Reducing oxygen levels in blood results in increased activity of the carotid body cells and reflex increases in sympathetic nerve activity. A key contributor to elevated sympathetic nerve activity in neurogenic forms of hypertension is enhanced peripheral chemorecept...
Sengupta, Arjun Ghosh, Soumita Sharma, Shobhona Sonawat, Haripalsingh M.
Published in
Metabolites
Investigation of glucose utilization during an infection is central to the study of energy metabolism. The heavy utilization of glucose by the malaria parasite, and the consequences of this process, have been investigated extensively. However, host glucose utilization during early infection has not been explored to date. In a first attempt, this ar...
Qiang, Shan Wang, Jing Xiong, Xiao Chao Qu, Yu Ling Liu, Liang Hu, Ching Yuan Meng, Yong Hong
Published in
Frontiers in Microbiology
As a valuable carotenoid, β-carotene is commercially used in food, cosmetics, animal feeds, and other industries. Metabolic engineering of microorganisms has been widely explored to improve the production of β-carotene. Compared with the traditional genetic modifications mainly focused on the pathways of mevalonate (MVA) and β-carotene biosynthesis...
Harris, David A Mina, Amir Cabarkapa, Dimitrije Heshmati, Keyvan Subramaniam, Renuka Banks, Alexander S Tavakkoli, Ali Sheu, Eric G
Published in
American journal of physiology. Endocrinology and metabolism
Sleeve gastrectomy (SG) induces weight loss-independent improvements in glucose homeostasis by unknown mechanisms. We sought to identify the metabolic adaptations responsible for these improvements. Nonobese C57BL/6J mice on standard chow underwent SG or sham surgery. Functional testing and indirect calorimetry were used to capture metabolic phenot...
Keramida, Georgia Roldao Pereira, Luisa Kaya, Guven Peters, A Michael
Published in
Clinical physiology and functional imaging
The study aim was to investigate the relationships of blood glucose level (BGL) with hepatic and splenic blood FDG clearances (Ki) in patients with diabetes mellitus (DM) and/or hepatic steatosis (HS). This was a retrospective study of 238 patients, including 92 with type 2 DM (DM2) and 11 with type 1 DM (DM1), having routine whole body FDG PET/CT....
Kang, Bean-Bu Chiang, Been-Huang
Published in
Phytotherapy research : PTR
Dysregulation of vesicle trafficking in muscle is one of the factors responsible for the pathogenesis of insulin resistance (IR). Ferulic acid (FER) and resveratrol (RSV) are known to have hypoglycemic property. In this study, differentiated L6 myotubes were induced with palmitate as a model of IR. Chemical ablation of muscle vesicles was used to i...
Pérez-Pevida, Belén Escalada, Javier Miras, Alexander D. Frühbeck, Gema
Published in
Frontiers in Endocrinology
Type 2 diabetes prevalence is increasing dramatically worldwide. Metabolic surgery is the most effective treatment for selected patients with diabetes and/or obesity. When compared to intensive medical therapy and lifestyle intervention, metabolic surgery has shown superiority in achieving glycemic improvement, reducing number of medications and ca...
