Prabakaran, Ashok Daniel Chung, Hyun-Jy McFarland, Kevin Govindarajan, Thirupugal Soussi, Fadoua El Abdellaoui Durumutla, Hima Bindu Villa, Chiara Piczer, Kevin Latimer, Hannah Werbrich, Cole
...
Published in
bioRxiv : the preprint server for biology
The genetic determinants of the glucocorticoid receptor (GR) metabolic action remain largely unelucidated. This is a compelling gap in knowledge for the GR single nucleotide polymorphism (SNP) rs6190 (p.R23K), which has been associated in humans with enhanced metabolic health but whose mechanism of action remains completely unknown. We generated tr...
tonyali, nazan vanli karabay, gulsan arslan, burak aktemur, gizem cakir, betul tokgoz seyhanli, zeynep çendek, busra demir ergani, seval yilmaz eroglu, hasan mermi, sumeyye
...
Background/Objectives: Gestational diabetes mellitus (GDM) presents significant risks for both maternal and neonatal health, affecting fetal growth and increasing the likelihood of future diabetes mellitus (DM) development in affected women. The dysregulation of metabolic biomarkers, including catestatin, has been implicated in GDM pathophysiology....
Kamale, Chinmay Rauniyar, Abhishek Bhaumik, Prasenjit
Published in
The FEBS journal
Cellulases are an ensemble of enzymes that hydrolyze cellulose chains into fermentable glucose and hence are widely used in bioethanol production. The last enzyme of the cellulose degradation pathway, β-glucosidase, is inhibited by its product, glucose. The product inhibition by glucose hinders cellulose hydrolysis limiting the saccharification dur...
Sakai, Hiromichi Murakami, Chiaki Takechi, Mayumi Urano, Takeshi Sakane, Fumio
Published in
FASEB bioAdvances
Diacylglycerol kinase δ (DGKδ) phosphorylates diacylglycerol to produce phosphatidic acid. Previously, we demonstrated that down-regulation of DGKδ suppresses the myogenic differentiation of C2C12 myoblasts. However, the myogenic roles of DGKδ in vivo remain unclear. In the present study, we generated DGKδ-conditional knockout mice under the contro...
glendinning, john i. williams, niki
Background/Objectives: There is controversy about the health risks of sugary diets. A recent study reported that chronic consumption of 11% sugar solutions improved glycemic control in lean mice. Based on this finding, we hypothesized that chronic consumption of the same 11% sugar solutions would also improve glycemic control in metabolically deran...
vásquez-reyes, sarai bernal-gámez, miranda domínguez-chávez, jorge mondragón-vásquez, karina sánchez-tapia, mónica ordaz, guillermo granados-portillo, omar coutiño-hernández, diana barrera-gómez, paulina torres, nimbe
...
Background/Objective: In recent studies, it has been shown that dietary bioactive compounds can produce health benefits; however, it is not known whether an improvement in solubility can enhance their biological effects. Thus, the aim of this work was to study whether co-amorphous (CoA) naringenin or fisetin with enhanced solubility modify glucose ...
Bonet, J Weiss, R Galderisi, A Dalla Man, C Caprio, S Santoro, N
Published in
American journal of physiology. Endocrinology and metabolism
Obesity is one of the leading causes of the development of insulin resistance, diabetes, and metabolic dysfunction-associated steatotic liver disease (MASLD) in children. With the progression of insulin resistance, both glucose and free fatty acid (FFA) plasma levels are elevated, leading to cardiometabolic complications such as impaired glucose to...
McFadden, Samuel A Peck, Mackenzie R Sime, Lindsey N Cox, MaKayla F Ikiz, Erol D Findley, Caleigh A Quinn, Kathleen Fang, Yimin Bartke, Andrzej Hascup, Erin R
...
Published in
Aging
A thermoregulatory decline occurs with age due to changes in muscle mass, vasoconstriction, and metabolism that lowers core body temperature (Tc). Although lower Tc is a biomarker of successful aging, we have previously shown this worsens cognitive performance in the APP/PS1 mouse model of Alzheimer's disease (AD). We hypothesized that elevating Tc...
Farhadi-Azar, Mahbanoo Noroozzadeh, Mahsa Mousavi, Maryam Saei Ghare Naz, Marzieh Ramezani Tehrani, Fahimeh
Published in
Experimental physiology
Polycystic ovary syndrome (PCOS), one of the most common endocrine disorders in reproductive-aged women, is associated with metabolic disturbances. The present study aimed to examine changes in body weight (BW) and glucose and insulin tolerance in a prenatally-androgenized (PNA) rat model of PCOS compared to control with increasing age. Pregnant ra...
jeon, jungmin lee, sung won park, hyun jung park, yun hoo kim, tae-cheol lee, sujin lee, seyeong van kaer, luc hong, seokmann
The SWItch3-related gene (SRG3) is a core component of ATP-dependent SWI/SNF complexes, which are crucial for regulating immune cell development and function (e.g., macrophages and CD4+ T cells), embryonic development, and non-immune cell differentiation. Notably, SRG3 overexpression has been shown to polarize macrophages in the central nervous sys...