Kang, Taegyu Cha, Gi Doo Park, Ok Kyu Cho, Hye Rim Kim, Minjeong Lee, Jongha Kim, Dokyoon Lee, Bowon Chu, Jinyoung Koo, Sagang
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Published in
ACS nano
Postsurgical treatment of glioblastoma multiforme (GBM) by systemic chemotherapy and radiotherapy is often inefficient. Tumor cells infiltrating deeply into the brain parenchyma are significant obstacles to the eradication of GBM. Here, we present a potential solution to this challenge by introducing an injectable thermoresponsive hydrogel nanocomp...
burko, pavel d’amico, giuseppa miltykh, ilia scalia, federica de macario, everly conway l. macario, alberto j. giglia, giuseppe cappello, francesco bavisotto, celeste caruso
Glioblastoma multiforme (GBM) is a primary brain tumor that is very aggressive, resistant to treatment, and characterized by a high degree of anaplasia and proliferation. Routine treatment includes ablative surgery, chemotherapy, and radiotherapy. However, GMB rapidly relapses and develops radioresistance. Here, we briefly review the mechanisms und...
bafiti, vivi ouzounis, sotiris siapi, eleni grypari, ioanna maria theofanopoulos, andreas panagiotopoulos, vasilios zolota, vasiliki kardamakis, dimitrios katsila, theodora
The accumulation of cell biomass is associated with dramatically increased bioenergetic and biosynthetic demand. Metabolic reprogramming, once thought as an epiphenomenon, currently relates to disease progression, also in response to extracellular fate-decisive signals. Glioblastoma multiforme patients often suffer misdiagnosis, short survival time...
pöhlking, celine beier, sebastian formanski, jan patrick friese, michael schreiber, michael schwalbe, birco
This study aimed to isolate cells from grade 4 glioblastoma multiforme tumors for infection experiments with Zika virus (ZIKV) prME or ME enveloped HIV-1 pseudotypes. The cells obtained from tumor tissue were successfully cultured in human cerebrospinal fluid (hCSF) or a mixture of hCSF/DMEM in cell culture flasks with polar and hydrophilic surface...
evers, lara schäfer, agnes pini, raffaella zhao, kai stei, susanne nimsky, christopher bartsch, jörg w.
Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor in adults. Despite multimodal therapy, median survival is poor at 12–15 months. At the molecular level, radio-/chemoresistance and resulting tumor progression are attributed to a small fraction of tumor cells, termed glioblastoma stem-like cells (GSCs). These CD133-expre...
makowska, marianna smolarz, beata romanowicz, hanna
Glioblastoma multiforme (GBM) is the most common, malignant, poorly promising primary brain tumor. GBM is characterized by an infiltrating growth nature, abundant vascularization, and a rapid and aggressive clinical course. For many years, the standard treatment of gliomas has invariably been surgical treatment supported by radio- and chemotherapy....
vaidya, manjusha sreerama, sandeep gonzalez-vega, maxine smith, jonhoi field, melvin sugaya, kiminobu
Glioblastoma multiforme (GBM) possesses a small but significant population of cancer stem cells (CSCs) thought to play a role in its invasiveness, recurrence, and metastasis. The CSCs display transcriptional profiles for multipotency, self-renewal, tumorigenesis, and therapy resistance. There are two possible theories regarding the origin of CSCs i...
korbecki, jan rębacz-maron, ewa kupnicka, patrycja chlubek, dariusz baranowska-bosiacka, irena
Glioblastoma multiforme (GBM) is one of the most aggressive gliomas. New and more effective therapeutic approaches are being sought based on studies of the various mechanisms of GBM tumorigenesis, including the synthesis and metabolism of arachidonic acid (ARA), an omega-6 polyunsaturated fatty acid (PUFA). PubMed, GEPIA, and the transcriptomics an...
Decotret, Lisa R. Shi, Rocky Thomas, Kiersten N. Hsu, Manchi Pallen, Catherine J. Bennewith, Kevin L.
Published in
Frontiers in Oncology
Organotypic cultures of murine brain slices are well-established tools in neuroscience research, including electrophysiology studies, modeling neurodegeneration, and cancer research. Here, we present an optimized ex vivo brain slice invasion assay that models glioblastoma multiforme (GBM) cell invasion into organotypic brain slices. Using this mode...
suthiram, janine pieters, ané moosa, zulfiah mohamed zeevaart, jan rijn sathekge, mike m. ebenhan, thomas anderson, ross c. newton, claire l.
Radiopharmaceutical development hinges on the affinity and selectivity of the biological component for the intended target. An analogue of the neuropeptide Substance P (SP), 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-[Thi8,Met(O2)11]-SP (DOTA-[Thi8,Met(O2)11]SP), in the theranostic pair [68Ga]Ga-/ [213Bi]Bi-DOTA-[Thi8,Met(O2)11]SP has...
