Lange, Sigrun
Published in
Neural regeneration research
Peptidylarginine deiminases are a family of calcium-activated enzymes with multifaceted roles in physiological and pathological processes, including in the central nervous system. Peptidylarginine deiminases cause post-translational deimination/citrullination, leading to changes in structure and function of a wide range of target proteins. Deiminat...
Gudoityte, Evelina Arandarcikaite, Odeta Mazeikiene, Ingrida Bendokas, Vidmantas Liobikas, Julius
Published in
International journal of molecular sciences
Ursolic and oleanolic acids are secondary plant metabolites that are known to be involved in the plant defence system against water loss and pathogens. Nowadays these triterpenoids are also regarded as potential pharmaceutical compounds and there is mounting experimental data that either purified compounds or triterpenoid-enriched plant extracts ex...
Rossmeisl, John H Herpai, Denise Quigley, Mindy Cecere, Thomas E Robertson, John L D'Agostino, Ralph B Hinckley, Jonathan Tatter, Stephen B Dickinson, Peter J Debinski, Waldemar
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Published in
Neuro-oncology
The interleukin-13 receptor alpha 2 (IL13RA2) and ephrin type A receptor 2 (EPHA2) are attractive therapeutic targets, being expressed in ~90% of canine and human gliomas, and absent in normal brain. Clinical trials using an earlier generation IL-13 based cytotoxin showed encouraging clinical effects in human glioma, but met with technical barriers...
Chuntova, Pavlina Chow, Frances Watchmaker, Payal B Galvez, Mildred Heimberger, Amy B Newell, Evan W Diaz, Aaron DePinho, Ronald A Li, Ming O Wherry, E John
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Published in
Neuro-oncology
Cancer immunotherapy has made remarkable advances with over 50 separate Food and Drug Administration (FDA) approvals as first- or second-line indications since 2015. These include immune checkpoint blocking antibodies, chimeric antigen receptor-transduced T cells, and bispecific T-cell-engaging antibodies. While multiple cancer types now benefit fr...
Daniel, Andy G S Park, Ki Yun Roland, Jarod L Dierker, Donna Gross, James Humphries, Joseph B Hacker, Carl D Snyder, Abraham Z Shimony, Joshua S Leuthardt, Eric C
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Published in
Neuro-oncology
Glioblastoma (GBM; World Health Organization grade IV) assumes a variable appearance on MRI owing to heterogeneous proliferation and infiltration of its cells. As a result, the neurovascular units responsible for functional connectivity (FC) may exist within gross tumor boundaries, albeit with altered magnitude. Therefore, we hypothesize that the s...
Pellecchia, Simona De Martino, Marco Esposito, Francesco Quintavalle, Cristina Fusco, Alfredo Pallante, Pierlorenzo
Published in
Cell cycle (Georgetown, Tex.)
Glioblastoma (GBM) is the most aggressive and lethal neoplasia of the central nervous system in adults. Based on the molecular signature genes, GBM has been classified in proneural, neural, mesenchymal and classical subtypes. The Metallophosphoesterase-domain-containing protein 2 (MPPED2) gene encodes a metallophosphodiesterase protein highly conse...
Ishii, Hiroko Mimura, Yuki Zahra, Maram H. Katayama, Shota Hassan, Ghmkin Afify, Said M. Seno, Masaharu
Cancer stem cell (CSC) is considered as a cause of cancer recurrence and metastasis. Simultaneously CSCs are responsible for the heterogeneous population in tumor tissues due to their differentiation potential. However, the characterizations of CSCs are still not enough and cancer stem cell lines widely available is desired to be established for th...
Zottel, Alja
Glioblastom (GBM) je najpogostejši primarni možganski tumor, ki se pojavlja s pogostnostjo 3,2 primera na 100 000 prebivalcev. Kljub uveljavljenem zdravljenju, ki obsega kirurško odstranitev tumorja, kemoterapijo s temozolomidom in radioterapijo, večina bolnikov ne preživi več kot 18 mesecev po postavljeni diagnozi. Eden izmed sodobnih možnih način...
Daniel, Andy GS Park, Ki Yun Roland, Jarod L Dierker, Donna Gross, James Humphries, Joseph B Hacker, Carl D Snyder, Abraham Z Shimony, Joshua S Leuthardt, Eric C
...
BackgroundGlioblastoma (GBM; World Health Organization grade IV) assumes a variable appearance on MRI owing to heterogeneous proliferation and infiltration of its cells. As a result, the neurovascular units responsible for functional connectivity (FC) may exist within gross tumor boundaries, albeit with altered magnitude. Therefore, we hypothesize ...
Feng, Xing Zhang, Heng Meng, Lingbing Song, Huiwen Zhou, Qingxin Qu, Chao Zhao, Pan Li, Qinghua Zou, Chang Liu, Xing
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Published in
Autophagy
Although the treatment of brain tumors by targeting kinase-regulated macroautophagy/autophagy, is under investigation, the precise mechanism underlying autophagy initiation and its significance in glioblastoma (GBM) remains to be defined. Here, we report that PAK1 (p21 [RAC1] activated kinase 1) is significantly upregulated and promotes GBM develop...
