Mladek, Ann C Yan, Huihuang Tian, Shulan Decker, Paul A Burgenske, Danielle M Bakken, Katrina Hu, Zeng He, Lihong Connors, Margaret A Carlson, Brett L
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Published in
Neuro-oncology
RBBP4 activates transcription by histone acetylation, but the partner histone acetyltransferases are unknown. Thus, we investigated the hypothesis that RBBP4 interacts with p300 in a complex in glioblastoma (GBM). shRNA silencing of RBBP4 or p300 and RNAseq was used to identify genes co-regulated by RBBP4 and p300 in GBM43 patient-derived xenograft...
Brown, Christine E Rodriguez, Analiz Palmer, Joycelynne Ostberg, Julie R Naranjo, Araceli Wagner, Jamie R Aguilar, Brenda Starr, Renate Weng, Lihong Synold, Timothy W
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Published in
Neuro-oncology
Wide-spread application of chimeric antigen receptor (CAR) T cell therapy for cancer is limited by the current use of autologous CAR T cells necessitating the manufacture of individualized therapeutic products for each patient. To address this challenge, we have generated an off-the-shelf, allogeneic CAR T cell product for the treatment of glioblas...
Sun, Stella Kiang, Karrie Mei-Yee Leung, Gilberto Ka-Kit
Published in
Oncology letters
Prolyl 4-hydroxylase beta polypeptide (P4HB) is a chaperone protein associated with temozolomide (TMZ) resistance through the unfolded protein response. Cancer cells with constitutive activation of endoplasmic reticulum stress and upregulation of P4HB have been observed to show resistance against chemotherapies. The present study focused on the eva...
Liu, Zhi Wang, Zhaotao Chen, Danmin Liu, Xiaorui Yu, Guoyong Zhang, Yan Chen, Chen Xu, Ruxiang Wang, Yezhong Liu, Ru-en
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Published in
Frontiers in Oncology
Epithelial-to-mesenchymal transition (EMT) and angiogenesis have emerged as two pivotal events in cancer progression. Paeoniflorin has been widely studied in experimental models and clinical trials for cancer treatment because of its anti-cancer property. However, the underlying mechanisms of paeoniflorin in EMT and angiogenesis in glioblastoma was...
Lombardi, Francesca Augello, Francesca Rosaria Artone, Serena Ayroldi, Emira Giusti, Ilaria Dolo, Vincenza Cifone, Maria Grazia Cinque, Benedetta Palumbo, Paola
Published in
Frontiers in Oncology
Temozolomide (TMZ) resistance is frequent in patients with glioblastoma (GBM), a tumor characterized by a marked inflammatory microenvironment. Recently, we reported that cyclooxygenase-2 (COX-2) is upregulated in TMZ-resistant GBM cells treated with high TMZ concentrations. Moreover, COX-2 activity inhibition significantly counteracted TMZ-resista...
Mander, Sunam Naffouje, Samer A. Gao, Jin Li, Weiguo Christov, Konstantin Green, Albert Bongarzone, Ernesto R. Das Gupta, Tapas K. Yamada, Tohru
Published in
Frontiers in Oncology
Despite recent advances in cancer research, glioblastoma multiforme (GBM) remains a highly aggressive brain tumor as its treatment options are limited. The current standard treatment includes surgery followed by radiotherapy and adjuvant chemotherapy. However, surgery without image guidance is often challenging to achieve maximal safe resection as ...
Najlaoui, Feten Busser, Benoit Taïwe, Germain Sotoing Pigeon, Pascal Sturm, Nathalie Giovannini, Diane Marrakchi, Naziha Rhouma, Ali Jaouen, Gérard Gibaud, Stéphane
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Published in
Molecules (Basel, Switzerland)
SuccFerr (N-[4-ferrocenyl,5-5-bis (4-hydroxyphenyl)-pent-4-enyl]-succinimide) has remarkable antiproliferative effects in vitro, attributed to the formation of a stabilized quinone methide. The present article reports in vivo results for a possible preclinical study. SuccFerr is lipophilic and insoluble in water, so the development of a formulation...
Luo, Na Sun, Xizi Ma, Shengling Li, Xiaoyu Zhu, Wenjun Fu, Min Yang, Feng Chen, Ziqi Li, Qianxia Zhang, Yuanyuan
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Published in
Frontiers in Oncology
Background Accumulating evidence shows that m6A regulates oncogene and tumor suppressor gene expression, thus playing a dual role in cancer. Likewise, there is a close relationship between the immune system and tumor development and progression. However, for glioblastoma, m6A-associated immunological markers remain to be identified. Methods We obta...
Xu, Baohui Chen, Rongmei Zhou, Jiuren Liang, Jie
Published in
Micromachines
Along with deep scaling transistors and complex electronics information exchange networks, very-large-scale-integrated (VLSI) circuits require high performance and ultra-low power consumption. In order to meet the demand of data-abundant workloads and their energy efficiency, improving only the transistor performance would not be sufficient. Super ...
Qin, Lili Du, Fei Yang, Ningning Zhang, Chen Wang, Zhiwen Zheng, Xingwen Tang, Jiawei Yang, Liangbo Dong, Chen
Published in
Molecules (Basel, Switzerland)
As the largest group of structurally diverse metabolites, terpenoids are versatile natural compounds that act as metabolism mediators, plant volatiles, and ecological communicators. However, few terpenoid compounds have been identified in plant parts of sacred lotus (Nelumbo nucifera Gaertn.). To elucidate the molecular genetic basis of the terpene...
