Looijaard, Stéphanie M L M Te Lintel Hekkert, Miriam L Wüst, Rob C I Otten, René H J Meskers, Carel G M Maier, Andrea B
Published in
Acta physiologica (Oxford, England)
Low skeletal muscle mass is highly prevalent in older cancer patients and affects 5% to 89% depending on the type and stage of cancer. Low skeletal muscle mass is associated with poor clinical outcomes such as post-operative complications, chemotherapy toxicity and mortality in older cancer patients. Little is known about the mediating pathophysiol...
Hantel, Andrew DuMontier, Clark Odejide, Oreofe O Luskin, Marlise R Sperling, Adam S Hshieh, Tammy Chen, Richard Soiffer, Robert Driver, Jane A Abel, Gregory A
...
Published in
Cancer
Brief measures of physical function such as gait speed may be useful to optimize treatment intensity for older adults who have blood cancer; however, little is known about whether such assessments are already captured within oncologists' "gestalt" assessments. Gait speed was assessed in 782 patients ≥75 years of age who had blood cancer, with resul...
Adashek, Jacob J Subbiah, Ishwaria M
Published in
ESMO Open
The steady advances in oncology bring a host of therapeutic options for older adults (≤65 years old) with cancer. As these patients experience this proliferation of anticancer therapies, their caregivers too have witnessed their role rapidly expanding and evolving as they care for these individuals. To better understand the caregiver experience, a ...
Gomes, Fabio Lewis, Anna Morris, Rob Parks, Ruth Kalsi, Tania Babic-Illamn, Gordana Baxter, Mark Colquhoun, Kirsty Rodgers, Lisa Smith, Eleanor
...
Published in
ecancermedicalscience
The ageing population poses new challenges globally. Cancer care for older patients is one of these challenges, and it has a significant impact on societies. In the United Kingdom (UK), as the number of older cancer patients increases, the management of this group has become part of daily practice for most oncology teams in every geographical area....
Hauchecorne, Mathilde Pierro, Monica Brain, Etienne Bringuier, Michael Soubeyran, Pierre Chakiba, Camille Mathoulin-Pelissier, Simone Paillaud, Elena Geiss, Romain Besse, Benjamin
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Published in
ecancermedicalscience
In France, cancer is the leading cause of death. Its incidence is increasing due to the growing population and longer life expectancy. Although older adults represent most new cases, they remain underrepresented in clinical trials. Their prognosis is often worse due to delayed diagnosis and multimorbidities. Geriatric oncology has made great stride...
Wyld, Lynda Bellantuono, Ilaria Tchkonia, Tamara Morgan, Jenna Turner, Olivia Foss, Fiona George, Jayan Danson, Sarah Kirkland, James L.
Published in
Cancers
Cellular senescence is a key component of human aging that can be induced by a range of stimuli, including DNA damage, cellular stress, telomere shortening, and the activation of oncogenes. Senescence is generally regarded as a tumour suppressive process, both by preventing cancer cell proliferation and suppressing malignant progression from pre-ma...
Blakely, Andrew M Chanson, Dayana Wong, F Lennie Eng, Oliver S Sentovich, Stephen M Melstrom, Kurt A Lai, Lily L Fong, Yuman Sun, Virginia
Published in
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
Data regarding changes in functional status and health-related quality of life (HRQOL) before and after surgery are lacking. We identified colorectal cancer patients from the SEER-Medicare Health Outcomes Survey (MHOS) linked database to evaluate the association between HRQOL and survival. HRQOL survey data captured physical/mental health, activiti...
Liu, Jennifer Gutierrez, Eutiquio Tiwari, Abhay Padam, Simran Li, Daneng Dale, William Pal, Sumanta K. Stewart, Daphne Subbiah, Shanmugga Bosserman, Linda D.
...
Published in
Journal of Clinical Medicine
Cancer is a disease associated with aging. As the US population ages, the number of older adults with cancer is projected to dramatically increase. Despite this, older adults remain vastly underrepresented in research that sets the standards for cancer treatments and, consequently, clinicians struggle with how to interpret data from clinical trials...
Krok-Schoen, Jessica L. Naughton, Michelle J. Noonan, Anne M. Pisegna, Janell DeSalvo, Jennifer Lustberg, Maryam B.
Published in
Cancer Control : Journal of the Moffitt Cancer Center
The Commission on Cancer’s standard 3.3 represents a paradigm shift in the care of cancer survivors, recommending that survivors receive a treatment summary and survivorship care plan (SCPs). A focus on older breast cancer survivors is needed, as they are the majority of the breast cancer population and their experiences and perspectives of SCPs is...
Lage, Daniel E DuMontier, Clark Lee, Yoojin Nipp, Ryan D Mitchell, Susan L Temel, Jennifer S El-Jawahri, Areej Berry, Sarah D
Published in
Cancer
This study examined factors associated with potentially burdensome end-of-life (EOL) transitions between care settings among older adults with advanced cancer in nursing homes (NHs). A retrospective analysis of deceased older NH residents with poor-prognosis solid tumors was conducted with Medicare claims and the Minimum Data Set. A potentially bur...
