Chen, Guanzhong Liu, Liwei Li, Huanqiang Lun, Zhubin Mai, Ziling Lai, Wenguang Chen, Enzhao Zhou, Chunyun Yu, Sijia Yang, Junqing
...
Published in
Frontiers in Genetics
Background Acute myocardial infarction (AMI), characterized by an event of myocardial necrosis, is a common cardiac emergency worldwide. However, the genetic mechanisms of AMI remain largely elusive. Methods A genome-wide association study dataset of AMI was obtained from the CARDIoGRAMplusC4D project. A transcriptome-wide association study (TWAS) ...
Ando, Kunie Houben, Sarah Homa, Mégane de Fisenne, Marie-Ange Potier, Marie-Claude Erneux, Christophe Brion, Jean-Pierre Leroy, Karelle
Published in
Frontiers in Molecular Neuroscience
Luo, Ming Zhang, Yuxiao Huang, Shishu Song, Yueming
Published in
Frontiers in Genetics
Genome-wide association studies have identified many susceptibility genes for adolescent idiopathic scoliosis (AIS). However, most of the results are hard to be replicated in multi-ethnic populations. LBX1 is the most promising candidate gene in the etiology of AIS. We aimed to appraise the literature for the association of LBX1 gene polymorphisms ...
Ratnasekera, Pulindu McNeney, Brad
Published in
Frontiers in Genetics
We investigate the impact of confounding on the results of a genome-wide association analysis by Beaty et al., which identified multiple single nucleotide polymorphisms that appeared to modify the effect of maternal smoking, alcohol consumption, or multivitamin supplementation on risk of cleft palate. The study sample of case-parent trios was prima...
Tong, Hang Phan, Nga V T Nguyen, Thanh T Nguyen, Dinh V Vo, Nam S Le, Ly
Published in
Pharmacogenomics and Personalized Medicine
Pharmacogenomics has been used effectively in studying adverse drug reactions by determining the person-specific genetic factors associated with individual response to a drug. Current approaches have revealed the significant importance of sequencing technologies and sequence analysis strategies for interpreting the contribution of genetic variation...
Kokhmetova, Alma Sehgal, Deepmala Ali, Shaukat Atishova, Makpal Kumarbayeva, Madina Leonova, Irina Dreisigacker, Susanne
Published in
Frontiers in Genetics
Tan spot, caused by Pyrenophora tritici-repentis , is a serious foliar disease of wheat in Kazakhstan with reported yield losses as high as 50% during epidemic years. Here, we report the evaluation of a collection of 191 hexaploid spring and winter wheat lines for tan spot resistance and its underlying genetic architecture using genome-wide associa...
Ferrer, Marina Aguilera, Mònica Martinez, Vicente
Published in
International journal of molecular sciences
Rifaximin is a broad-spectrum antibiotic that ameliorates symptomatology in inflammatory/functional gastrointestinal disorders. We assessed changes in gut commensal microbiota (GCM) and Toll-like receptors (TLRs) associated to rifaximin treatment in mice. Adult C57BL/6NCrl mice were treated (7/14 days) with rifaximin (50/150 mg/mouse/day, PO). Lumi...
Harden, K. Paige
Behavior genetics studies how genetic differences among people contribute to differences in their psychology and behavior. Here, I describe how the conclusions and methods of behavior genetics have evolved in the postgenomic era in which the human genome can be directly measured. First, I revisit the first law of behavioral genetics stating that ev...
Bay, Camden P Levy, Steven M Janz, Kathleen F Smith, Brian J Shaffer, John R Marazita, Mary L Burns, Trudy L
Published in
Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry
The foundation for osteoporosis risk is, in part, established during childhood, adolescence, and young adulthood, all periods of development when bone mass is acquired rapidly. The relative quantity of bone mass accrued is influenced by both lifestyle and genetic factors, although the genetic component is not yet well understood. The purpose of thi...
Herrera-Luis, Esther Espuela-Ortiz, Antonio Lorenzo-Diaz, Fabian Keys, Kevin L Mak, Angel C Y Eng, Celeste Huntsman, Scott Villar, Jesús Rodriguez-Santana, Jose R Burchard, Esteban G
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Published in
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
Severe asthma exacerbations are a major cause of asthma morbidity and increased healthcare costs. Several studies have shown racial and ethnic differences in asthma exacerbation rates. We aimed to identify genetic variants associated with severe exacerbations in two high-risk populations for asthma. A genome-wide association study of asthma in chil...
