Howe, Kerstin Chow, William Collins, Joanna Pelan, Sarah Pointon, Damon-Lee Sims, Ying Torrance, James Tracey, Alan Wood, Jonathan
Published in
GigaScience
Genome sequence assemblies provide the basis for our understanding of biology. Generating error-free assemblies is therefore the ultimate, but sadly still unachieved goal of a multitude of research projects. Despite the ever-advancing improvements in data generation, assembly algorithms and pipelines, no automated approach has so far reliably gener...
Nakajima, Hideaki
Published in
Internal medicine (Tokyo, Japan)
Myelodysplastic syndromes (MDS) are clonal hematological disorders arising from hematopoietic stem cells that have accumulated various genetic abnormalities. MDS are heterogeneous in nature but uniformly characterized by chronic and progressive cytopenia from ineffective hematopoiesis, dysplasia in single or multiple lineages, and transformation to...
Ejiofor, Promise Frank
Published in
Human Affairs
With the recent advancements in scientific comprehension of genetics and the decipherment of complex techniques for editing human genomes, liberal eugenics—eugenic ideal premised on the liberal values of autonomy and pluralism that leaves reproductive choices to parents rather than anachronistic statist authoritarian interventions—has inevitably be...
Kim, Jong-Bo Yang, Hwan-Rae Lee, Sang-Hee Park, Tae-Ho
Published in
Mitochondrial DNA. Part B, Resources
Alstroemeria , a member of the Alstroemeriaceae family, is a species from South America. The chloroplast genome of Alstroemeria spp. was completed by de novo assembly using a small amount of whole genome sequencing data. The chloroplast genome of Alstroemeria spp. was 155,672 bp in length consisting of 84,379 bp of large single copy, 17,815 bp of s...
Nagy, Ádám Pongor, Sándor Győrffy, Balázs
Published in
International journal of antimicrobial agents
Genomic alterations in a viral genome can lead to either better or worse outcome and identifying these mutations is of utmost importance. Here, we correlated protein-level mutations in the SARS-CoV-2 virus to clinical outcome. Mutations in viral sequences from the GISAID virus repository were evaluated by using "hCoV-19/Wuhan/WIV04/2019" as the ref...
Li, Kun Liu, Juanjuan Zeng, Zhibo Kulyar, Muhammad Fakhar-e-Alam Wang, Yaping Li, Aoyun Bhutta, Zeeshan Ahmad Aqib, Amjad Islam Shahzad, Muhammad Li, Jiakui
...
Published in
Genes
Probiotic bacteria are receiving increased attention due to the potential benefits to their hosts. Plateau yaks have resistance against diseases and stress, which is potentially related to their inner probiotics. To uncover the potential functional genes of yak probiotics, we sequenced the whole genome of Lactobacillus sakei ( L. sakei ). The resul...
Marques-Pereira, Catarina Proença, Diogo Neves Morais, Paula V
Published in
Biology
Serratia strains are ubiquitous microorganisms with the ability to produce serratomolides, such as serrawettins. These extracellular lipopeptides are described as biocides against many bacteria and fungi and may have a nematicidal activity against phytopathogenic nematodes. Serrawettins W1 and W2 from different strains have different structures tha...
Montarry, Josselin Mimee, Benjamin Danchin, Etienne G J Koutsovoulos, Georgios D Ste-Croix, Dave T Grenier, Eric
Published in
Phytopathology
Plant-parasitic nematodes are a costly burden of crop production. Ubiquitous in nature, phytoparasitic nematodes are associated with nearly every important agricultural crop and represent a significant constraint on global food security. Population genetics is a key discipline in plant nematology to understand aspects of the life strategies of thes...
Ma, Xiaonan Li, Zhenghe
Published in
Viruses
Generation of recombinant negative-stranded RNA viruses (NSVs) from plasmids involves in vivo reconstitution of biologically active nucleocapsids and faces a unique antisense problem where the negative-sense viral genomic RNAs can hybridize to viral messenger RNAs. To overcome this problem, a positive-sense RNA approach has been devised through exp...
Devanga Ragupathi, Naveen Kumar Muthuirulandi Sethuvel, Dhiviya Prabaa Triplicane Dwarakanathan, Hariharan Murugan, Dhivya Umashankar, Yamini Monk, Peter N. Karunakaran, Esther Veeraraghavan, Balaji
Published in
Frontiers in Microbiology
Klebsiella pneumoniae is one of the leading causes of nosocomial infections. Carbapenem-resistant K. pneumoniae are on the rise globally. The biofilm forming ability of K. pneumoni ae further complicates patient management. There is still a knowledge gap on the association of biofilm formation with patient outcome and carbapenem susceptibility, whi...