cătană, andreea iordănescu, irina filip, gheorghe gerald filip, simona militaru, mariela sanda pătrășcanu, andrada-adelaida pîrlog, lorin-manuel
Background. Breast cancer remains a leading cause of cancer-related death among women, with genetic mutations playing a key role. While high-penetrance mutations are well-studied, moderate-to-low-penetrance mutations, which present challenges in clinical decision-making and patient outcomes, are less understood. This study explores the quality of l...
Kayali, Stefano Fantasia, Stefano Gaiani, Federica Cavallaro, Lucas Giovanni de'Angelis, Gian Luigi Laghi, Luigi
Published in
Inflammatory bowel diseases
NOD2 is the most relevant susceptibility gene for Crohn’s disease. It is associated with the tructuring disease phenotype, ileal involvement, and an increased risk for surgery. NOD2 genetic variants emerge as promising candidates for developing precision medicine in Crohn’s disease.
jašinskienė, eglė sniečkutė, ieva galminas, ignas žemaitis, lukas simutis, mantas čaplinskienė, marija
Background and Objective: Unexplained infertility is a major challenge in reproductive medicine and requires advanced diagnostic approaches to identify the underlying factors accurately. This study aims to evaluate the utility of risk factor analysis and a gene panel in diagnosing unexplained infertility using the next-generation sequencing (NGS) t...
alijanpourotaghsara, amirreza vessal, arsalan alijanpour, amirmasoud strelnikov, david piroska, marton persely, aliz jokkel, zsofia szalontai, laszlo forgo, bianka kozak, lajos rudolf
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Background and Objective: Brain morphometry is shaped by a complex interplay of genetic and environmental factors, including physiological and neuropsychiatric conditions. These influences can vary across distinct brain regions, yet the precise contributions of genetics and environment to regional variation in healthy brains remain poorly understoo...
lin, xijuan kang, jia zhu, lan
Vaginal atresia is a rare anomaly of the female reproductive tract that significantly impacts women’s reproductive health and quality of life. Although there has been relatively extensive research on the clinical manifestations and differential diagnosis of vaginal atresia, there is a paucity of literature specifically addressing the genetic backgr...
sipowicz, kasper pietras, tadeusz sobstyl, michał mosiołek, anna różycka-kosmalska, monika mosiołek, jadwiga stefanik-markowska, ewa ring, michał kamecki, krystian kosmalski, marcin
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Dissocial personality is understood as a personality that does not ideologize most social norms and is characterized by a lack of empathy. Precise criteria for diagnosing dissocial personality are included in the ICD-10 classification, which is still in force in Poland. This classification is widely available in both Polish and English. In Poland, ...
Chica-Pérez, Anabel Martínez-Sola, Lucía Correa-Casado, Matías Fernández-Sola, Cayetano El Marbouhe El Faqyr, Karim Hernández-Padilla, José Manuel
Published in
Healthcare (Basel, Switzerland)
Aim: To examine and map health programmes that have been implemented and evaluated to improve health outcomes amongst older adults who are the primary family caregivers for their partners. Methods: A scoping review was carried out, following the methodology of the Joanna Briggs Institute (JBI) and PRISMA-ScR reporting guidelines. The search was con...
Zhao, Jianyu Song, Weiyuan Zhang, Xiaolan
Published in
The New phytologist
Fruit development can be generally classified into a set of biologically sequential stages including fruit initiation, growth, and ripening. Cucumber, a globally important vegetable crop, displays two important features during fruit development: parthenocarpy at fruit initiation and prematurity at harvest for consumption. Therefore, fruit growth pl...
Tsirelis, Daniil Tsekouras, Alexandros Stamati, Polyxeni Liampas, Ioannis Zoupa, Elli Dastamani, Metaxia Tsouris, Zisis Papadimitriou, Anastasios Dardiotis, Efthimios Siokas, Vasileios
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Published in
Reviews in the Neurosciences
Migraine is a multidimensional disease affecting a large portion of the human population presenting with a variety of symptoms. In the era of personalized medicine, successful migraine treatment presents a challenge, as several studies have shown the impact of a patient’s genetic profile on therapy response. However, with the emergence of contempor...
makita, yuko reich, heather n.
Immunoglobulin A nephropathy (IgAN) is the most prevalent primary glomerular disease worldwide and it remains a leading cause of kidney failure. Clinical manifestations of IgA are exacerbated by infections, and emerging data suggest that aberrant mucosal immune responses are important contributors to the immunopathogenesis of this disease. However,...