Din, Muhammad Azhar Ud Wan, Aijun Chu, Ying Zhou, Jing Yan, Yongmin Xu, Zhiliang
Published in
Frontiers in Medicine
The chronic immune-mediated inflammatory condition known as inflammatory bowel disease (IBD) significantly affects the gastrointestinal system. While the precise etiology of IBD remains elusive, extensive research suggests that a range of pathophysiological pathways and immunopathological mechanisms may significantly contribute as potential factors...
Kaleem, Mohammed Thool, Mandar Dumore, Nitin G. Abdulrahman, Abdulrasheed O. Ahmad, Wasim Almostadi, Amal Alhashmi, Mohammad Hassan Kamal, Mohammad Amjad Tabrez, Shams
Published in
Frontiers in Genetics
Aborode, Abdullahi Tunde Kumar, Neeraj Olowosoke, Christopher Busayo Ibisanmi, Tope Abraham Ayoade, Islamiyyah Umar, Haruna Isiyaku Jamiu, Abdullahi Temitope Bolarinwa, Basit Olapade, Zainab Idowu, Abidemi Ruth
...
Published in
Frontiers in Bioinformatics
Introduction: This work utilizes predictive modeling in drug discovery to unravel potential candidate genes from Escherichia coli that are implicated in antimicrobial resistance; we subsequently target the gidB, MacB, and KatG genes with some compounds from plants with reported antibacterial potentials. Method: The resistance genes and plasmids wer...
Gumus, Nurcan
Glioblastoma is the deadliest type of brain tumour, and many therapy approaches have been applied to increase the median life expectancy. However, clinical outcomes have not improved, and innovative glioblastoma treatments are needed. Targeting GLI1-3 and GLI-associated genes (GLIPR1 and GLIS1-3 gene family), which contribute to glioblastoma pathog...
Blazekovic, Antonela Gotovac Jercic, Kristina Devedija, Sabina Borovecki, Fran
Published in
Frontiers in Cognition
Parkinson's disease (PD) is a complex disorder that is influenced by multiple genetic risk factors. There is a significant heterogeneity in PD presentation, both pathologically and clinically. Some of the most common and important symptoms affecting the patient are cognitive impairment and dementia. However, the genetic and biological basis underly...
Jiang, Liangliang Qiao, Qiushuang Wang, Jing
Published in
Frigid Zone Medicine
Objective The aim of this study was to identify biomarkers associated with immunity and prognosis in patients with cervical cancer. Materials and methods Data from patients with cervical squamous cell carcinoma (CESC) were retrieved from the UCSC Xena database and subjected to analysis. Gene sets representing 22 types of immunocytes were acquired, ...
Zhang, Hao Shi, Shengbo Huang, Xingxing Gong, Changsheng Zhang, Zijing Zhao, Zetian Gao, Junxiao Zhang, Meng Yu, Xiaobing
Published in
Frontiers in Immunology
Background Intervertebral Disc Degeneration (IDD) is a major cause of lower back pain and a significant global health issue. However, the specific mechanisms of IDD remain unclear. This study aims to identify key genes and pathways associated with IDD using bioinformatics and machine learning algorithms. Methods Gene expression profiles, including ...
Al-Fadhli, Amani H. Jamal, Wafaa Yousef
Published in
Frontiers in Cellular and Infection Microbiology
Antibiotic resistance, a known global health challenge, involves the flow of bacteria and their genes among animals, humans, and their surrounding environment. It occurs when bacteria evolve and become less responsive to the drugs designated to kill them, making infections harder to treat. Despite several obstacles preventing the spread of genes an...
Yang, Yufang Tuo, Jinmei Zhang, Jun Xu, Zucai Luo, Zhong
Published in
Frontiers in Neurology
Sleep-related hypermotor epilepsy (SHE) is a focal epilepsy syndrome characterized by a variable age of onset and heterogeneous etiology. Current literature suggests a prevalence rate of approximately 1.8 per 100,000 persons. The discovery of additional pathogenic genes associated with SHE in recent years has significantly expanded the knowledge an...
Öztan, Gözde
Published in
Turkish Journal of Biochemistry
Objectives Raynaud’s phenomenon (RP) is a disease that causes discoloration of the fingers. The purpose of this study is to identify the molecular pathways in which genes related to RP illness are involved, as well as uncover the biological processes and molecular functions connected with those genes via the use of gene ontology (GO) analysis. Meth...
