Lin, Yu-Tzu Tseng, Sung-Pin Hung, Wei-Wen Chang, Chen-Chia Chen, You-Han Jao, Ya-Ting Chen, Yen-Hsu Teng, Lee-Jene Hung, Wei-Chun
Published in
Microorganisms
Sequence type 59 (ST59) is the dominant type of community-associated methicillin-resistant Staphylococcus aureus (MRSA) in Taiwan. Previously, we reported that ST59 MRSA harbors enterococcal IS 1216V -mediated multidrug-resistant composite transposons MESPM1 or MES6272-2. The MES were found to have a mosaic structure, largely originating in enteroc...
Rossi, Carlo Lees, Mark Mehta, Vedanta Heikura, Tommi Martin, John Zachary, Ian Spencer, Rebecca Peebles, Donald M Shaw, Robert Karhinen, Minna
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Published in
Human gene therapy
Severe fetal growth restriction (FGR) affects 1:500 pregnancies, is untreatable and causes serious neonatal morbidity and death. Reduced uterine blood flow (UBF) and lack of bioavailable VEGF due to placental insufficiency is a major cause. Transduction of uterine arteries in normal or FGR sheep and guinea pigs using an adenovirus (Ad) encoding VEG...
Biferi, Maria Grazia Cohen-Tannoudji, Mathilde García-Silva, Andrea Souto-Rodríguez, Olga Viéitez-González, Irene San-Millán-Tejado, Beatriz Fernández-Carrera, Andrea Pérez-Márquez, Tania Teijeira-Bautista, Susana Barrera, Soraya
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Published in
Molecular Therapy. Methods & Clinical Development
This study focuses on the development of a novel gene therapy vector for Fabry disease (FD). The approach is based on the systemic delivery of an AAV9, which crosses the blood brain barrier and drives sustained expression of α-galactosidase A, reducing pathological signs in multiple organs of a FD mouse model, including the central nervous system.
Gao, Chengwen Wu, Chuanhong Zhang, Qian Zhao, Xia Wu, Mingxuan Chen, Ruirui Zhao, Yalin Li, Zhiqiang
Published in
Frontiers in Genetics
Salvia species have been widely used as medicinal plants and have played an important role in the treatment and recovery of individuals with COVID-19. In this study, we reported two newly identified whole chloroplast genome sequences of Salvia medicinal plants ( Salvia yangii and Salvia miltiorrhiza f. alba ) and compared them with those of seven o...
Tang, Qiushi Keeler, Allison M. Zhang, Songbo Su, Qin Lyu, Zhuoyao Cheng, Yangfan Gao, Guangping Flotte, Terence R.
Published in
BioResearch Open Access
A number of packaging systems are available for production of recombinant adeno-associated virus vectors (rAAVs). Among these, the use of a two-plasmid cotransfection system, in which Rep and Cap genes and Ad helper genes are on the same plasmid, has not been frequently employed for good manufacturing practices (GMP) production, even though it pres...
Tang, Qiushi Keeler, Allison M. Zhang, Songbo Su, Qin Lyu, Zhuoyao Cheng, Yangfan Gao, Guangping Flotte, Terence R.
A number of packaging systems are available for production of recombinant adeno-associated virus vectors (rAAVs). Among these, the use of a two-plasmid cotransfection system, in which Rep and Cap genes and Ad helper genes are on the same plasmid, has not been frequently employed for good manufacturing practices (GMP) production, even though it pres...
Roy, Alexandra-Sophie Woehle, Christian LaRoche, Julie
Published in
Frontiers in Microbiology
Ferredoxins are iron–sulfur proteins essential for a wide range of organisms because they are an electron transfer mediator involved in multiple metabolic pathways. In phytoplankton, these proteins are active in the mature chloroplasts, but the petF gene, encoding for ferredoxin, has been found either to be in the chloroplast genome or transferred ...
Libante, Virginie Sarica, Nazim Mohamad Ali, Abbas Gapp, Chloé Oussalah, Anissa Guédon, Gérard Leblond-Bourget, Nathalie Payot, Sophie
Published in
Genes
Integrative mobilizable elements (IMEs) are widespread but very poorly studied integrated elements that can excise and hijack the transfer apparatus of co-resident conjugative elements to promote their own spreading. Sixty-four putative IMEs, harboring closely related mobilization and recombination modules, were found in 14 Streptococcus species an...
Crippen, Clay S. Jr., Michael J. Rothrock Sanchez, Susan Szymanski, Christine M.
Published in
Frontiers in Microbiology
Antimicrobial resistance is an ancient bacterial defense mechanism that has rapidly spread due to the frequent use of antibiotics for disease treatment and livestock growth promotion. We are becoming increasingly aware that pathogens, such as members of the genus Acinetobacter , are precipitously evolving drug resistances through multiple mechanism...
Liu, Chunyan Zhang, Ligang Zhu, Wenhui Guo, Raoqing Sun, Huamin Chen, Xi Deng, Ning
Published in
Molecular Therapy. Methods & Clinical Development
The concept of lipoplexes applied to cancer gene therapy has been popular for decades; however, no such medicine has been marketed. Deng and colleagues highlight the physiological barriers against the clinical success of the cationic liposomal gene delivery system in cancer therapy. They suggest that the rational design of clinically applicable lip...
