Benli-Hoppe, Teoman Göl Öztürk, Şurhan Öztürk, Özgür Berger, Simone Wagner, Ernst Yazdi, Mina
Published in
Macromolecular rapid communications
Human transferrin protein (Tf) modified polyplexes have already displayed encouraging potential for receptor-mediated nucleic acid delivery into tumors. The use of a blood-derived targeting protein and polydisperse macromolecular cationic subunits however presents a practical challenge for pharmaceutical grade production. Here, Tf receptor (TfR) ta...
Park, H-K Ryu, M-H Hwang, D-S Kim, G-C Jang, M-A Kim, U-K
Published in
International journal of oral and maxillofacial surgery
Melatonin receptors can inhibit breast and prostate cancers; however, little is known regarding their effects on oral squamous cell carcinoma. In this study, we collected specimens from 81 patients with oral squamous cell carcinoma and analysed clinicopathological data retrospectively. In addition, the expression of the melatonin receptor was analy...
Capelôa, Leon Yazdi, Mina Zhang, Heyang Chen, Xiaobing Nie, Yu Wagner, Ernst Lächelt, Ulrich Barz, Matthias
Published in
Macromolecular rapid communications
ABC-type triblock copolymers are a rising platform especially for oligonucleotide delivery as they offer an additional functionality besides the anyhow needed functions of shielding and complexation. The authors present a polypept(o)ide-based triblock copolymer synthesized by amine-initiated ring-opening polymerization (ROP) of N-carboxyanhydrides ...
akbar;, sehrish
Plant viruses are devastating plant pathogens that severely affect crop yield and quality. Plants have developed multiple lines of defense systems to combat viral infection. Gene silencing/RNA interference is the key defense system in plants that inhibits the virulence and multiplication of pathogens. The general mechanism of RNAi involves (i) the ...
n., nikolay
Recent investigations have shown the possibility of artificial induction of RNA interference (RNAi) via plant foliar treatments with naked double-stranded RNA (dsRNA) to silence essential genes in plant fungal pathogens or to target viral RNAs. Furthermore, several studies have documented the downregulation of plant endogenous genes via external ap...
villegas-estrada;, bernardo
Post-transcriptional gene silencing (PTGS) is an evolutionarily conserved plant defense mechanism against viruses. This paper aimed to evaluate a dsDNA construct (77 bp) as a template for in vitro production of virus-derived artificial small hairpin RNAs (shRNAs) and test for their potential to trigger the RNAi mechanism in Nicotiana benthamiana pl...
Holm, Anja Hansen, Stine N. Klitgaard, Henrik Kauppinen, Sakari
Published in
RNA Biology
RNA therapeutics comprise a diverse group of oligonucleotide-based drugs such as antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), and short hairpin RNAs (shRNAs) that can be designed to selectively interact with drug targets currently undruggable with small molecule-based drugs or monoclonal antibodies. Furthermore, RNA-based the...
zhu;, li zhaoyuan
Safe and efficient delivery of small interfering RNA (siRNA) is essential to gene therapy towards intervention of genetic diseases. Herein, we developed a novel cationic cholesterol lipid derivative (CEL) in which cholesterol hydrophobic skeleton was connected to L-lysine cationic headgroup via a hexanediol linker as the non-viral siRNA delivery ca...
Masrori, Pegah Ospitalieri, Simona Forsberg, Karin Moens, Thomas G Poesen, Koen Race, Valerie Brännström, Thomas Andersen, Peter M Thal, Dietmar R Van Damme, Philip
...
Published in
European journal of neurology
With the advent of gene therapies for amyotrophic lateral sclerosis (ALS), the importance of gene testing in ALS is increasing. This will likely lead to the identification of new variants for which the pathogenicity is not established. We aimed to study the pathogenicity of a newly identified variant in superoxide dismutase 1 (SOD1). Gene testing w...
Masrori, Pegah; Ospitalieri, Simona; Forsberg, Karin; Moens, Thomas G; Poesen, Koen; 46862; Race, Valerie; Brannstrom, Thomas; Andersen, Peter M; Thal, Dietmar R; 97737; Van Damme, Philip; 34370;
...
BACKGROUND AND PURPOSE: With the advent of gene therapies for amyotrophic lateral sclerosis (ALS), the importance of gene testing in ALS is increasing. This will likely lead to the identification of new variants for which the pathogenicity is not established. We aimed to study the pathogenicity of a newly identified variant in superoxide dismutase ...
