Long, Jianyin Galvan, Daniel L Mise, Koki Kanwar, Yashpal S Li, Li Poungavrin, Naravat Overbeek, Paul A Chang, Benny H Danesh, Farhad R
Published in
The Journal of biological chemistry
Long noncoding RNAs (lncRNAs) have been shown to play key roles in a variety of biological activities of the cell. However, less is known about how lncRNAs respond to environmental cues and what transcriptional mechanisms regulate their expression. Studies from our laboratory have shown that the lncRNA Tug1 (taurine upregulated gene 1) is crucial f...
Lejars, Maxence Kobayashi, Asaki Hajnsdorf, Eliane
Prokaryotes encounter constant and often brutal modifications to their environment. In order to survive, they need to maintain fitness, which includes adapting their protein expression patterns. Many factors control gene expression but this review focuses on just one, namely antisense RNAs (asRNAs), a class of non-coding RNAs (ncRNAs) characterized...
Shen, Hui Ontiveros, Robert Jordan Owens, Michael C Liu, Monica Yun Ghanty, Uday Kohli, Rahul M Liu, Kathy Fange
Published in
The Journal of biological chemistry
Oxidation of 5-methylcytosine (5mC) in DNA by the Ten-eleven translocation (TET) family of enzymes is indispensable for gene regulation in mammals. More recently, evidence has emerged to support a biological function for TET-mediated m5C oxidation in messenger RNA. Here, we describe a previously uncharacterized role of TET-mediated m5C oxidation in...
Krey, Karsten Babnis, Aleksandra W. Pichlmair, Andreas
Published in
Viruses
Viruses pose substantial challenges for society, economy, healthcare systems, and research. Their distinctive pathologies are based on specific interactions with cellular factors. In order to develop new antiviral treatments, it is of central importance to understand how viruses interact with their host and how infected cells react to the virus on ...
Spidlova, Petra Stojkova, Pavla Sjöstedt, Anders Stulik, Jiri
Published in
Microorganisms
Regulation of gene transcription is the initial step in the complex process that controls gene expression within bacteria. Transcriptional control involves the joint effort of RNA polymerases and numerous other regulatory factors. Whether global or local, positive or negative, regulators play an essential role in the bacterial cell. For instance, s...
Alexandre, Pâmela A. Hudson, Nicholas J. Lehnert, Sigrid A. Fortes, Marina R. S. Naval-Sánchez, Marina Nguyen, Loan T. Porto-Neto, Laercio R. Reverter, Antonio
Published in
Genes
Genome-wide gene expression analysis are routinely used to gain a systems-level understanding of complex processes, including network connectivity. Network connectivity tends to be built on a small subset of extremely high co-expression signals that are deemed significant, but this overlooks the vast majority of pairwise signals. Here, we developed...
Rogers, Alicia K Phillips, Carolyn M
Published in
Cell reports
RNA interference (RNAi) is an essential regulatory mechanism in all animals. In Caenorhabditis elegans, several classes of small RNAs act to silence or license expression of mRNA targets. ERI-6/7 is required for the production of some endogenous small interfering RNAs (siRNAs) and acts as a negative regulator of the exogenous RNAi pathway. We find ...
Uchitomi, Ran Oyabu, Mamoru Kamei, Yasutomi
Published in
Nutrients
Skeletal muscle, the largest organ in the human body, accounting for approximately 40% of body weight, plays important roles in exercise and energy expenditure. In the elderly, there is often a progressive decline in skeletal muscle mass and function, a condition known as sarcopenia, which can lead to bedridden conditions, wheelchair confinement as...
Jiang, S. M. Huang, R. Z. Jiang, Y. B. Li, Z. B.
Published in
Russian Journal of Plant Physiology
AbstractThis paper is try to investigate the molecular mechanisms of cadmium (Cd) response in mulberry (Morus alba L.) leaf. Transcriptome sequencing technology is used to analyze the profiles of low-Cd mulberry Zhehulusang (zhls) and high-Cd mulberry Xianmianzao (xmz) under Cd stress. Approximately 195 million clean reads were obtained, 2785 and 1...
Vicente, Isabel Baroncelli, Riccardo Morán-Diez, María Eugenia Bernardi, Rodolfo Puntoni, Grazia Hermosa, Rosa Monte, Enrique Vannacci, Giovanni Sarrocco, Sabrina
Published in
Microorganisms
Trichoderma is a fungal genus comprising species used as biocontrol agents in crop plant protection and with high value for industry. The beneficial effects of these species are supported by the secondary metabolites they produce. Terpenoid compounds are key players in the interaction of Trichoderma spp. with the environment and with their fungal a...
