Staller, Max Valentin
Transcription factors regulate gene expression by binding to regulatory DNA and recruiting regulatory protein complexes. The DNA-binding and protein-binding functions of transcription factors are traditionally described as independent functions performed by modular protein domains. Here, I argue that genome binding can be a two-part process with bo...
Farrow, Sophie L Schierding, William Gokuladhas, Sreemol Golovina, Evgeniia Fadason, Tayaza Cooper, Antony A O'Sullivan, Justin M
Published in
Brain : a journal of neurology
The latest meta-analysis of genome-wide association studies identified 90 independent variants across 78 genomic regions associated with Parkinson's disease, yet the mechanisms by which these variants influence the development of the disease remains largely elusive. To establish the functional gene regulatory networks associated with Parkinson's di...
Han, Yu Nie, Jiali Wang, Dao Wen Ni, Li
Published in
Frontiers in Cardiovascular Medicine
Cardiac hypertrophy is a key process in cardiac remodeling development, leading to ventricle enlargement and heart failure. Recently, studies show the complicated relation between cardiac hypertrophy and epigenetic modification. Post-translational modification of histone is an essential part of epigenetic modification, which is relevant to multiple...
Shirinian, Margret Chen, Chong Uchida, Shusaku Jadavji, Nafisa M.
Published in
Frontiers in Molecular Neuroscience
Dos Santos, José Diogo Neves João, Susana Afonso Martín, Jesús Vicente, Francisca Reyes, Fernando Lage, Olga Maria
Published in
Microorganisms
Oceans hold a stunning number of unique microorganisms, which remain unstudied by culture-dependent methods due to failures in establishing the right conditions for these organisms to grow. In this work, an isolation effort inspired by the iChip was performed using marine sediments from Memoria beach, Portugal. The isolates obtained were identified...
Pavlenko, Egor Ruengeler, Till Engel, Paulina Poepsel, Simon
Published in
Frontiers in Genetics
Mammalian histone demethylases of the KDM5 family are mediators of gene expression dynamics during developmental, cellular differentiation, and other nuclear processes. They belong to the large group of JmjC domain containing, 2-oxoglutarate (2-OG) dependent oxygenases and target methylated lysine 4 of histone H3 (H3K4me1/2/3), an epigenetic mark a...
Bajaj, Priyanka Manjunath, Kavyashree Varadarajan, Raghavan
Published in
Protein science : a publication of the Protein Society
Mutations that affect protein binding to a cognate partner primarily occur either at buried residues or at exposed residues directly involved in partner binding. Distinguishing between these two categories based solely on mutational phenotypes is challenging. The bacterial toxin CcdB kills cells by binding to DNA Gyrase. Cell death is prevented by ...
Pai, Athma A. Li, Yang I. Provero, Paolo
Published in
Frontiers in Genetics
Frédérick, Pierre-Marc Simard, Martin J
Published in
Wiley interdisciplinary reviews. RNA
Among the different types of small RNAs, microRNAs (miRNAs) are key players in controlling gene expression at the mRNA level. To be active, they must associate with an Argonaute protein to form the miRNA induced silencing complex (miRISC) and binds to specific mRNA through complementarity sequences. The miRISC binding to an mRNA can lead to multipl...
Ashby, Ethan Paddock, Lucinda Betts, Hannah L Liao, Jingwen Miller, Geneva Porter, Anya Rollosson, Lindsey M Saada, Carrie Tang, Eric Wade, Serenity J
...
Published in
mSphere
Trypanosoma brucei, the causative agent of human and animal African trypanosomiasis, cycles between a mammalian host and a tsetse fly vector. The parasite undergoes huge changes in morphology and metabolism during adaptation to each host environment. These changes are reflected in the different transcriptomes of parasites living in each host. Howev...