Published in Microorganisms
The global increase in antimicrobial resistance has revived the interest in “old” substances with antimicrobial activity such as sodium bituminosulfonate. However, for those “old” compounds, scientific studies are still sparse and the ones available do not mostly meet the current standards. Since this compound is used for topical applications, inve...
Published in British journal of clinical pharmacology
For management of osteoarticular infections, rifampicin appears to be the key antibiotic. We aimed to evaluate the actual rifampicin dosing regimens using a population pharmacokinetic model of rifampicin in patients with osteoarticular infections. A Monte Carlo simulation study was performed to simulate steady-state plasma concentrations for 1000 r...
Published in Future medicinal chemistry
Aim: Fusidic acid (FA) is a narrow-spectrum bacteriostatic antibiotic. We inadvertently discovered that a FA derivative modified by an amino-terminal group at the 3-OH position, namely 2, inhibited the growth of Cryptococcus neoformans. Methods & results: Multiscale molecular modeling approaches were used to analyze the binding modes of 2 with eEF2...
Published in Pharmaceutics
With the alarming rise in incidence of antibiotic-resistant bacteria and the scarcity of newly developed antibiotics, it is imperative that we design more effective formulations for already marketed antimicrobial agents. Fusidic acid (FA), one of the most widely used antibiotics in the topical treatment of several skin and eye infections, suffers f...
Published in Russian Journal of Organic Chemistry
Reactions of 3,11-dioxo fusidane triterpenoids with hydroxylamine in anhydrous ethanol in the presence of a catalytic amount of 4-(dimethylamino)pyridine afforded hydroxyimino derivatives of fusidic acid with high chemo- and stereoselectivity. The products were isolated as pure (3Z,11E) isomers. Their rearrangement by the action of both acid and al...
Published in International journal of nanomedicine
Fusidic acid (FA) and sodium fusidate (SF) have problems in their skin penetration and stability resulting in a reduction in their potency; therefore, the objective of this study was to develop FA and SF nanoemulgels to improve the antibacterial activity of the drugs. FA and SF nanoemulgel formulations were prepared by the incorporation of FA and S...
Published in Infection and Drug Resistance
Purpose There is a need for continuous surveillance of methicillin-resistant Staphylococcus aureus (MRSA) to identify emergence of new strains. We hypothesize that MRSA strains are evolving with ongoing acquisition of SCC mec elements. This study was carried out to evaluate the evolution of MRSA at a tertiary care facility in Saudi Arabia. Methods ...
Published in Family practice
There is a lack of recently published data on impetigo presentation incidence and treatment practices in the routine Western European primary care setting. To investigate impetigo incidence, treatments and recurrence in primary care in the Netherlands. A retrospective, observational study. Electronic records of patients treated for impetigo in 2015...
Published in British journal of clinical pharmacology
Following a severe case of rhabdomyolysis in our University Hospital after a co-administration of atorvastatin and fusidic acid, we describe this interaction as this combination is not clearly contraindicated in some countries, particularly for long-term treatment by fusidic acid. All cases of rhabdomyolysis during a co-administration of a statin a...
Published in Nanomedicine (London, England)
The aim of the current study was to investigate the therapeutic efficacy of cationic-charged bilayered nanoemulsion for topical delivery of fusidic acid in eradicating methicillin-resistant Staphylococcus aureus (MRSA) bacterial burn wound infection. The developed carriers were characterized for particle size, antibacterial activity, cell viability...
