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Hannich, Malte J. Konen, Franz F. Gag, Konrad Alkhayer, Aiham Türker, Seda N. Budde, Kathrin Nauck, Matthias Wurster, Ulrich Dressel, Alexander Skripuletz, Thomas
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Published in
Clinical Chemistry and Laboratory Medicine (CCLM)
Objectives Oligoclonal bands (OCB) analysis is the reference standard for detecting an intrathecal IgG synthesis. Alongside OCB, free light chains kappa (FLCκ) are considered an additional sensitive biomarker for determining patterns 2 or 3, indicating intrathecal Ig synthesis. However, kFLC IF is not suitable for detecting a monoclonal pattern 5. ...
hannich, malte johannes abdullah, mohammed r. budde, kathrin petersmann, astrid nauck, matthias dressel, alexander süße, marie
We performed this cohort study to test whether further analysis of intrathecal inflammation can be omitted if the free light chain kappa (FLCκ) quotient is within the reference range in the corresponding quotient diagram. FLCκ concentrations were measured in serum and cerebrospinal fluid (CSF) samples. The intrathecal fraction (IF) of FLCκ was calc...
süße, marie konen, franz felix schwenkenbecher, philipp budde, kathrin nauck, matthias grothe, matthias hannich, malte johannes skripuletz, thomas
Free light chains kappa (FLCκ) in cerebrospinal fluid (CSF) are a part of the intrathecal immune response. This observational study was conducted to investigate the effects of different disease-modifying therapies (DMT) on the humoral intrathecal immune response in the CSF of patients with multiple sclerosis (MS). FLCκ were analyzed in CSF and seru...
hannich, malte johannes dressel, alexander budde, kathrin petersmann, astrid nauck, matthias süße, marie
In this retrospective, monocentric cohort study, we tested if an intrathecal free light chain kappa (FLC-k) synthesis reflects not only an IgG but also IgA and IgM synthesis. We also analysed if FLC-k can help to distinguish between an inflammatory process and a blood contamination of cerebrospinal fluid (CSF). A total of 296 patient samples were i...