toda, haruki chin, takaaki
This study aimed to determine the characteristics of accelerations and angular velocities obtained by an inertial measurement unit (IMU) attached to a cane between older people with and without physical frailty. Community-dwelling older people walked at a comfortable speed using a cane with a built-in IMU. Physical frailty was assessed using exerci...
nguyen, nam p. page, brandi r. giap, huan dahbi, zineb vinh-hung, vincent gorobets, olena mohammadianpanah, mohammad motta, micaela portaluri, maurizio arenas, meritxell
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The standard of care for locally advanced non-small-cell lung cancer (NSCLC) is either surgery combined with chemotherapy pre- or postoperatively or concurrent chemotherapy and radiotherapy. However, older and frail patients may not be candidates for surgery and chemotherapy due to the high mortality risk and are frequently referred to radiotherapy...
Hillman, Kenneth M. Barnett, Adrian Brown, Christine Callaway, Leonie Cardona, Magnolia Carter, Hannah Farrington, Alison Harvey, Gillian Lee, Xing McPhail, Steven
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The current fallback position for the elderly frail nearing the end of life (less than 12 months to live) is hospitalisation. There is a reluctance to use the term ‘terminally ill’ for this population, resulting in overtreatment, overdiagnosis and management that is not consistent with the wishes of people. This is the major contributor to the so-c...
Corral-Pérez, Juan Casals, Cristina Ávila-Cabeza-de-Vaca, Laura González-Mariscal, Andrea Mier, Alba Espinar-Toledo, Milagrosa García-Agua Soler, Nuria Vázquez-Sánchez, María Á
Published in
Journal of applied gerontology : the official journal of the Southern Gerontological Society
This study investigated the relationship between physical activity, inactivity, physical function, and sleep in older adults with a frailty phenotype. A total of 184 pre-frail/frail older adults were included. Physical activity, inactive behavior, and sleep parameters were assessed using a wrist-worn accelerometer. Participants were categorized int...
horigome, yuichi suzuki, kazuhito suzuki, takahiro
Remarkable advancements have been made in the treatment outcomes of multiple myeloma (MM) patients; however, for frail elderly patients, these treatment outcomes are still insufficient. Elderly MM patients are increasing, as are their treatment regimens. There is a heightened demand to assess these patients in order to provide optimized treatments....
Han, Jiangxue Zhang, Qin Lan, Jiarong Yu, Fang Liu, Jie
Published in
Frontiers in Oncology
Background Colorectal cancer (CRC) is the 3rd most common cancer in men and 2nd most common malignancy in females across the globe leading to high mortality rates. Frailty is an age-related syndrome that has been associated with high morbidity and mortality. This systematic review aimed to examine if frailty can predict long-term (>1 year) outcomes...
Shrestha, Shakti Poudel, Arjun Steadman, Kathryn J. Nissen, Lisa M.
Deprescribing decision making in older adults with limited life expectancy is often challenging for clinicians. We aimed to develop and validate a Deprescribing Tool for Older People with Limited-life Expectancy (De-TOPPLE). Modified Delphi technique was used to gain experts' consensus on the tool and further develop using their feedback. Experts [...
Shrestha, Shakti Poudel, Arjun Steadman, Kathryn J Nissen, Lisa M
Published in
Basic & clinical pharmacology & toxicology
Deprescribing decision making in older adults with limited life expectancy is often challenging for clinicians. We aimed to develop and validate a Deprescribing Tool for Older People with Limited-life Expectancy (De-TOPPLE). Modified Delphi technique was used to gain experts' consensus on the tool and further develop using their feedback. Experts [...
Hilmer, Sarah Schwartz, Janice Petrovic, Mirko Walker, Lauren Thürmann, Petra Le Couteur, David
The International Union of Basic and Clinical Pharmacology (IUPHAR) Geriatric Committee aims to improve the use of drugs in older adults and develop new therapeutic approaches for the syndromes and diseases of old age through advocacy, education, and research. In the present paper, we propose strategies relevant to drug development and evaluation, ...
Diaz-Toro, Felipe Nazzal Nazal, Carolina Nazar, Gabriela Diaz-Martinez, Ximena Concha-Cisternas, Yeny Celis-Morales, Carlos Petermann-Rocha, Fanny
Published in
Journal of aging and physical activity
To investigate how frailty modifies the association of sitting time with all-cause and cardiovascular mortality in Chilean adults. This prospective study included 2,604 participants aged ≥35 from the Chilean National Health Survey 2009-2010. Sitting time was self-reported, while frailty was assessed using a 36-item Frailty Index. Sitting time was c...
