Lu, Ke Jia, Xiaodan Wu, Jiaqi Wang, Qiuling Liang, Xu-Fang
Published in
Frontiers in Cell and Developmental Biology
Neuropeptide Y receptor Y2 (npy2r) is an important receptor gene involved in anxiety and feeding regulation in mammals. Since NPY receptors have different receptor gene deletions in mammals and teleost fish, it is not clear whether npy2r has the similar function in fish as in mammals. In this study, we used the CRISPR/Cas9 system to establish npy2r...
Gui, Yijun Dahir, Naima S Wu, Yanan Downing, Griffin Sweeney, Patrick Cone, Roger D
Published in
Cell reports
The melanocortin-3 receptor (MC3R) is a negative regulator of the central melanocortin circuitry via presynaptic expression on agouti-related protein (AgRP) nerve terminals, from where it regulates GABA release onto secondary MC4R-expressing neurons. However, MC3R knockout (KO) mice also exhibit defective behavioral and neuroendocrine responses to ...
Liu, Zhaoxun Xiao, Tao Liu, Hailan
Published in
Frontiers in Neuroscience
Leptin plays a critical role in regulating appetite, energy expenditure and body weight, making it a key factor in maintaining a healthy balance. Despite numerous efforts to develop therapeutic interventions targeting leptin signaling, their effectiveness has been limited, underscoring the importance of gaining a better understanding of the mechani...
Viallard, Flore Lefebvre, Sébastien Petry, Alexandre Vonfeld, Irène Quintard, Benoît
Nutrient intake of captive primates does not necessarily reflect that of their wild counterparts. Diets in captivity are often higher in non-structural carbohydrates and lower in fibre, resulting in health issues such as obesity, dental issues, diarrhoea and behavioural problems. The main objective of this study was to establish and monitor a chang...
Zheng, Yunhua Ye, Cheng He, Mulan Ko, Wendy K. W. Chan, Ying Wai Wong, Anderson O. L.
Published in
Frontiers in Endocrinology
Adiponectin (AdipoQ) is an adipokine involved in glucose homeostasis and lipid metabolism. In mammals, its role in appetite control is highly controversial. To shed light on the comparative aspects of AdipoQ in lower vertebrates, goldfish was used as a model to study feeding regulation by AdipoQ in fish species. As a first step, goldfish AdipoQ was...
Shoop, Rosemary
Anorexia/cachexia syndrome (ACS) causes the mortality of 20-30% of cancer patients and worsens the prognosis of many more. The mechanisms underlying ACS are poorly understood and, therefore, there is currently no effective method to combat this condition. Growth differentiation factor 15 (GDF15) is a cytokine which is released in response to cell s...
Bucher Della Torre, Sophie Lages, Marlene Dias, Sara S Guarino, Maria P Braga-Pontes, Cátia
Published in
JMIR serious games
Promoting healthy eating in children is key to preventing chronic diseases, and vegetable consumption is notably lower than recommended in this population. Among the interventions tested, gamification has shown promise in promoting familiarization, increasing knowledge, and potentially increasing vegetable intake. This pilot study aimed first to tr...
Diniz, Amanda Popolino Bressan, Josefina de Deus Mendonça, Raquel Coletro, Hillary Nascimento Carraro, Júlia Cristina Cardoso Pimenta, Adriano Marçal Hermsdorff, Helen Hermana Miranda Meireles, Adriana Lúcia
Published in
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition
In the absence of a recommendation for daily intake of phenolic compounds, to compare the intake of the main dietary polyphenols between populations is a really challenge. This study aimed to estimate the total dietary intake of polyphenols, classes and their food sources among Brazilian graduates and postgraduates. This was a cross-sectional study...
Heberden, Christine Maximin, Elise Rabot, Sylvie Naudon, Laurent
Published in
Nutritional neuroscience
Objective: Stressed individuals tend to turn to calorie-rich food, also known as 'comfort food' for the temporary relief it provides. The emotional eating drive is highly variable among subjects. Using a rodent model, we explored the plasmatic and neurobiological differences between 'high and low emotional eaters' (HEE and LEE).Methods: 40 male mic...
Chowdhury, Vishwajit S. Renaudeau, David Bungo, Takashi
Published in
Frontiers in Animal Science
