Georgi, Fanny Andriasyan, Vardan Witte, Robert Murer, Luca Hemmi, Silvio Yu, Lisa Grove, Melanie Meili, Nicole Kuttler, Fabien Yakimovich, Artur
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Published in
Antimicrobial Agents and Chemotherapy
Adenoviruses (AdVs) are prevalent and give rise to chronic and recurrent disease. Human AdV (HAdV) species B and C, such as HAdV-C2, -C5, and -B14, cause respiratory disease and constitute a health threat for immunocompromised individuals. HAdV-Cs are well known for lysing cells owing to the E3 CR1-β-encoded adenovirus death protein (ADP). We previ...
Barberio, Manuel Felli, Eric Pop, Raoul Pizzicannella, Margherita Geny, Bernard Lindner, Veronique Baiocchini, Andrea Jansen-Winkeln, Boris Moulla, Yusef Agnus, Vincent
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Published in
Cancers
Simple Summary Esophagectomy has a high rate of anastomotic complications thought to be caused by poor perfusion of the gastric graft, which is used to restore the continuity of the gastrointestinal tract. Ischemic gastric preconditioning (IGP), performed by partially destroying preoperatively the gastric vessels either by means of interventional r...
Geng, Qiang Fu, Zhiqiang Chen, Shih-Chi
Published in
Journal of Biomedical Optics
Significance: High-speed 3D imaging methods have been playing crucial roles in many biological discoveries. Aim: We present a hybrid light-field imaging system and image processing algorithm that can visualize high-speed biological events. Approach: The hybrid light-field imaging system uses the selective plane optical illumination, which simultane...
Nguyen, Thanh Bui, Vy Thai, Anh Lam, Van Raub, Christopher B. Chang, Lin-Ching Nehmetallah, George
Published in
Journal of Biomedical Optics
Significance: Our study introduces an application of deep learning to virtually generate fluorescence images to reduce the burdens of cost and time from considerable effort in sample preparation related to chemical fixation and staining. Aim: The objective of our work was to determine how successfully deep learning methods perform on fluorescence p...
Fujimoto, Shota Muguruma, Naoki Nakao, Michiyasu Ando, Hidenori Kashihara, Takanori Miyamoto, Yoshihiko Okamoto, Koichi Sano, Shigeki Ishida, Tatsuhiro Sato, Yasushi
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Published in
Journal of gastroenterology and hepatology
It is difficult to differentiate gastrointestinal stromal tumors (GISTs) from other subepithelial lesions under gastrointestinal endoscopy. Since most GISTs express tyrosine kinase receptor c-KIT, fluorescence-labeled c-KIT-specific tyrosine kinase inhibitors seem to be useful agents for molecular imaging of GIST. We aimed to develop a near-infrare...
Richter, Verena Lanzerstorfer, Peter Weghuber, Julian Schneckenburger, Herbert
Published in
International Journal of Molecular Sciences
Here, we present a simple and robust experimental setup for the super-resolution live cell microscopy of membrane-proximal fluorophores, which is comparably easy to perform and to implement. The method is based on Structured Illumination Microscopy (SIM) with a switchable spatial light modulator (SLM) and exchangeable objective lenses for epi-illum...
Marquardt, Christoph Kalev, Georgi Schiedeck, Thomas
Published in
Innovative Surgical Sciences
Objectives Assessing bowel perfusion with indocyanine green fluorescence angiography (ICG-FA) shows positive effects on anastomotic healing in colorectal surgery. Methods A retrospective evaluation of 296 colorectal resections where we performed ICG-FA was undertaken from January 2014 until December 2018. Perfusion of the bowel ends measured with I...
Pericoli, Giulia Petrini, Stefania Giorda, Ezio Ferretti, Roberta Ajmone-Cat, Maria Antonietta Court, Will Conti, Libenzio Adrian De Simone, Roberta Bencivenga, Paola Palma, Alessia
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Published in
International Journal of Molecular Sciences
The intratumor heterogeneity represents one of the most difficult challenges for the development of effective therapies to treat pediatric glioblastoma (pGBM) and diffuse intrinsic pontine glioma (DIPG). These brain tumors are composed of heterogeneous cell subpopulations that coexist and cooperate to build a functional network responsible for thei...
Shindo, Yutaka Yamanaka, Ryu Hotta, Kohji Oka, Kotaro
Published in
Nutrients
Magnesium plays important roles in the nervous system. An increase in the Mg2+ concentration in cerebrospinal fluid enhances neural functions, while Mg2+ deficiency is implicated in neuronal diseases in the central nervous system. We have previously demonstrated that high concentrations of glutamate induce excitotoxicity and elicit a transient incr...
Zhou, Jin Jangili, Paramesh Son, Subin Ji, Myung Sun Won, Miae Kim, Jong Seung
Published in
Advanced materials (Deerfield Beach, Fla.)
Neurodegenerative diseases are debilitating disorders that feature progressive and selective loss of function or structure of anatomically or physiologically associated neuronal systems. Both chronic and acute neurodegenerative diseases are associated with high morbidity and mortality along with the death of neurons in different areas of the brain;...
