Mu, Yu-rong Zhou, Meng-yuan Cai, Li Liu, Ming-ming Li, Rong
Published in
Journal of Inflammation Research
Introduction Previous studies have confirmed that aquaporin 1 (AQP1) is up-regulated in synovium of rheumatoid arthritis (RA), but its exact pathogenic mechanisms in RA are unclear. This study revealed the pathogenic role of AQP1 in rat collagen-induced arthritis (CIA) and the underlying mechanisms related to β-catenin signaling. Materials and Meth...
Zhu, Shangling Ye, Yuanmei Shi, Yiming Dang, Junlong Feng, Xiaoxue Chen, Yingdi Liu, Fang Olsen, Nancy Huang, Jianlin Zheng, Song Guo
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Published in
Frontiers in Immunology
Activated fibroblast-like synoviocytes (FLSs) play a central role in the formation of synovial pannus and joint destruction in rheumatoid arthritis (RA). Targeting FLSs could be a potential therapeutic strategy. The objective of this study is to explore the role of c-Jun N-terminal kinase (JNK) in proliferation, migration and invasion of FLSs promo...
Chen, Yong Qiu, Fujuan Yu, Beijia Chen, Yanjuan Zuo, Fangfang Zhu, XiaoYu Nandakumar, Kutty Selva Xiao, Changhong
Published in
Molecular Therapy. Methods & Clinical Development
AMPK levels positively correlated with inflammatory indexes in RA. Differentially expressed genes in the synovium indicate activation of FLS-specific metabolic pathways. An AMPK activator, metformin, has concentration-dependent effects on FLS proliferation. Metformin treatment significantly downregulated pro-inflammatory cytokines in FLS but upregu...
Gupta, Priya Kumar, Amit Pal, Subhashis Kumar, Sachin Lahiri, Amit Kumaravelu, Jagavelu Chattopadhyay, Naibedya Dikshit, Madhu Barthwal, Manoj Kumar
Published in
The Journal of pharmacy and pharmacology
This study was undertaken to evaluate the effect of Xylocarpus moluccensis fruit fraction (F018) on the pathogenesis of collagen-induced arthritis in mice. Arthritis was induced by intradermal injection of collagen (2 mg/ml) with complete Freund's adjuvant in DBA/1J mice. F018 was administered orally at 1, 3 and 10 mg/kg for 20 days. Disease progre...
Estell, Eben G Silverstein, Amy M Stefani, Robert M Lee, Andy J Murphy, Lance A Shah, Roshan P Ateshian, Gerard A Hung, Clark T
Published in
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
The synovium plays a key role in the development of osteoarthritis, as evidenced by pathological changes to the tissue observed in both early and late stages of the disease. One such change is the attachment of cartilage wear particles to the synovial intima. While this phenomenon has been well observed clinically, little is known of the biological...
Matsumura, Takashi Saito, Yuki Suzuki, Tomoyuki Teramoto, Atsushi Ozasa, Yasuhiro Yamashita, Toshihiko Fujimiya, Mineko Saito-Chikenji, Takako
Published in
Frontiers in immunology
Rheumatoid arthritis (RA) is an autoimmune disease caused by inflammation of the synovium and characterized by chronic polyarthritis that destroys bone and cartilage. Fibroblast-like synoviocytes (FLSs) in the synovium of patients with RA can promote cartilage and bone destruction by producing proteins such as matrix metalloproteinases and receptor...
Guo, Kai Bu, Xin Yang, Chongfei Cao, Xiaorui Bian, Huan Zhu, Qingsheng Zhu, Jinyu Zhang, Dawei
Published in
Frontiers in Immunology
Rheumatoid arthritis (RA) is a multifactorial autoimmune disease that primarily manifests as persistent synovitis and progressive joint destruction. Imatinib exhibited a therapeutic effect in murine collagen-induced arthritis (CIA) via selective inhibition tyrosine kinases. The second-generation tyrosine kinase inhibitor dasatinib exhibits more dur...
Bustamante, Marta F Oliveira, Patricia G Garcia-Carbonell, Ricard Croft, Adam P Smith, Jeff M Serrano, Ramon L Sanchez-Lopez, Elsa Liu, Xiao Kisseleva, Tatiana Hay, Nissim
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Published in
Annals of the rheumatic diseases
Recent studies indicate that glucose metabolism is altered in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS). Hexokinases (HKs) catalyse the first step in glucose metabolism, and HK2 constitutes the principal HK inducible isoform. We hypothesise that HK2 contributes to the synovial lining hypertrophy and plays a critical role in bone ...
Zhang, Yuqin Yan, Guohong Sun, Chengtao Nan, Lihong Wang, Xiaoying Xu, Wei Chu, Kedan
Published in
Inflammation
Compound 3R-(4′-hydroxyl-3′-O-β-D-glucopyranosyl phenyl)-dihydro isocoumarin (GDC) is a natural isocoumarin, recently isolated from the stems of H. paniculiflorum. However, we know little about the effects of GDC on rheumatoid arthritis (RA). This study aims to investigate the protective effects and potential mechanisms of GDC against LPS-induced i...
Svrcina, Haley Greer, Austin Baker, Seth Smith, Morgan Martinez, Patricia Granger, Nathan Thomas, Natassja Miller, Jaylin Steinke, Ellen Davitt, Kelsey
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Published in
Journal of cellular biochemistry
Earlier work in our laboratory demonstrated that naturally occurring reveromycin A (Rev A) causes apoptosis in osteoclasts without accompanying necrosis. Rev A death effects in both normal and diseased joint cells were investigated in this study. A dose of 10 μM Rev A did not cause apoptosis nor necrosis in monolayer chondrocytes, even at pH 6.8, a...
