Feng, Ji Lu, Pei-Zhi Zhu, Guang-Zhi Hooi, Shing Chung Wu, Yong Huang, Xiao-Wei Dai, Hui-Qi Chen, Pan-Hong Li, Zhong-Jie Su, Wen-Jing
...
Published in
Acta pharmacologica Sinica
Sorafenib is the first-line treatment of advanced hepatocellular carcinoma (HCC). However, there is a lack of validated biomarkers to predict sorafenib sensitivity. In this study we investigated the role of ACSL4, a positive-activating enzyme of ferroptosis, in sorafenib-induced cell death and HCC patient outcome. We showed that ACSL4 protein expre...
Woo, Yunseo Lee, Hyo-Ji Jung, Young Mee Jung, Yu-Jin
Published in
Cells
The treatment of tumors requires the induction of cell death. Radiotherapy, chemotherapy, and immunotherapy are administered to kill cancer cells; however, some cancer cells are resistant to these therapies. Therefore, effective treatments require various strategies for the induction of cell death. Regulated cell death (RCD) is systematically contr...
Flohé, Leopold
Published in
Antioxidants (Basel, Switzerland)
The beginnings of redox biology are recalled with special emphasis on formation, metabolism and function of reactive oxygen and nitrogen species in mammalian systems. The review covers the early history of heme peroxidases and the metabolism of hydrogen peroxide, the discovery of selenium as integral part of glutathione peroxidases, which expanded ...
Yi, Junmei Zhu, Jiajun Wu, Jiao Thompson, Craig B Jiang, Xuejun
Published in
Proceedings of the National Academy of Sciences of the United States of America
Ferroptosis, a form of regulated necrosis driven by iron-dependent peroxidation of phospholipids, is regulated by cellular metabolism, redox homeostasis, and various signaling pathways related to cancer. In this study, we found that activating mutation of phosphatidylinositol 3-kinase (PI3K) or loss of phosphatase and tensin homolog deleted on chro...
Lee, Ji-Yoon Nam, Miso Son, Hye Young Hyun, Kwangbeom Jang, Seo Young Kim, Jong Woo Kim, Min Wook Jung, Youngae Jang, Eunji Yoon, Seon-Jin
...
Published in
Proceedings of the National Academy of Sciences of the United States of America
Ferroptosis is an iron-dependent regulated necrosis mediated by lipid peroxidation. Cancer cells survive under metabolic stress conditions by altering lipid metabolism, which may alter their sensitivity to ferroptosis. However, the association between lipid metabolism and ferroptosis is not completely understood. In this study, we found that the ex...
Jhelum, Priya Santos-Nogueira, Eva Teo, Wulin Haumont, Alice Lenoël, Isadora Stys, Peter K David, Samuel
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Multiple sclerosis (MS) is a chronic demyelinating disease of the CNS. Cuprizone (CZ), a copper chelator, is widely used to study demyelination and remyelination in the CNS, in the context of MS. However, the mechanisms underlying oligodendrocyte (OL) cell loss and demyelination are not known. As copper-containing enzymes play important roles in ir...
Rink, Jonathan S Lin, Adam Yuh McMahon, Kaylin M Calvert, Andrea E Yang, Shuo Taxter, Tim Moreira, Jonathan Chadburn, Amy Behdad, Amir Karmali, Reem
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Published in
The Journal of biological chemistry
Normal human cells can either synthesize cholesterol or take it up from lipoproteins to meet their metabolic requirements. In some malignant cells, de novo cholesterol synthesis genes are transcriptionally silent or mutated, meaning that cholesterol uptake from lipoproteins is required for survival. Recent data suggest that lymphoma cells dependent...
Clemente, Sofia M Martínez-Costa, Oscar H Monsalve, Maria Samhan-Arias, Alejandro K
Published in
Molecules (Basel, Switzerland)
Cancer is one of the highest prevalent diseases in humans. The chances of surviving cancer and its prognosis are very dependent on the affected tissue, body location, and stage at which the disease is diagnosed. Researchers and pharmaceutical companies worldwide are pursuing many attempts to look for compounds to treat this malignancy. Most of the ...
Yang, Haitang Zhao, Liang Gao, Yanyun Yao, Feng Marti, Thomas M Schmid, Ralph A Peng, Ren-Wang
Published in
Cancers
(1) Background: Ferroptosis is an apoptosis-independent cell death program implicated in many diseases including cancer. Emerging evidence suggests ferroptosis as a promising avenue for cancer therapy, but the paucity of mechanistic understanding of ferroptosis regulation and lack of biomarkers for sensitivity to ferroptosis inducers have significa...
Chen, Xi Li, Dan Sun, Hai-Ying Wang, Wen-Wen Wu, Han Kong, Wen Kong, Wei-Jia
Published in
The FEBS journal
Central presbycusis is caused by degradation of the auditory centre during ageing. Its main characteristics are difficulties in understanding language and localizing sound. Presbycusis is an increasingly critical public health problem, but the underlying molecular mechanism has not been fully elucidated. Ferroptosis is a form of regulated cell deat...