Xu, Zilong You, Yanqiu Tang, Qiuqin Zeng, Hui Zhao, Tianshou Wang, Juan Li, Fujun
Published in
Pharmaceutical biology
Sevoflurane (Sev) is a commonly used surgical anaesthetic; it has neurotoxic effects on the brain. Echinatin (Ech) is reported to have anti-inflammatory and antioxidant activity. This research confirms the effect of Ech on Sev-induced neurotoxicity and cognitive deficits. Primary rat hippocampal neurons were treated with 4.1% Sev for 6 h in the pre...
Liu, Zhendong Xu, Yuyang Liu, Xin Wang, Baochun
Published in
Biochemistry and cell biology = Biochimie et biologie cellulaire
Chemotherapy is a commonly utilized treatment strategy for colon cancer, a prevalent malignancy. The study intends to probe the function and mechanism of protocadherin 7 (PCDH7) in colon cancer. Gain or loss of functional assays of PCDH7 was performed. MTT and colony formation assay monitored cell proliferation. Transwell measured migration and inv...
Chen, Zhian Li, Zhenhao Li, Chuangji Huang, Huilin Ren, Yingxin Li, Zhenyuan Hu, Yanfeng Guo, Weihong
Published in
Drug delivery
Gastric cancer (GC) is a serious disease with high morbidity and mortality rates worldwide. Chemotherapy plays a key role in GC treatment, while inevitable drug resistance and systematic side effects hinder its clinical application. Fenton chemistry-based chemodynamic therapy (CDT) has been used as a strategy for cancer ferroptosis, and the CDT eff...
Wu, Yanan Sun, Yanyan Wang, Xiaoyang Zhu, Changlian
Published in
Current neuropharmacology
Intracerebral hemorrhage (ICH) in preterm infants is one of the major co-morbidities of preterm birth and is associated with long-term neurodevelopmental deficits. There are currently no widely accepted treatments to prevent ICH or therapies for the neurological sequelae. With studies broadening the scope of cell death, the newly defined concept of...
Repar, Neža
Superparamagnetni nanodelci železovega oksida (SPIONi) imajo velik potencial za uporabo v medicini, vendar lahko zaradi oksidativnega stresa povzročajo neželene učinke. V naši študiji smo preučevali učinke SPIONov na endotelijske celice in ugotavljali, ali lahko oleinska kislina (OK) zaščiti celice pred njihovimi škodljivimi učinki. Uporabili smo t...
Su, Yali Sai, Yingying Zhou, Linfeng Liu, Zeliang Du, Panyan Wu, Jinghua Zhang, Jinghua
Published in
Frontiers in Oncology
Wang, Xinxing Xia, Guang Xiao, Shilang Wu, Song Zhang, Lina Huang, Junjie Zhang, Wenxiu Cao, Xu
Published in
Frontiers in Oncology
Background The role of ferroptosis in tumor progression and immune microenvironment is extensively investigated. However, the potential value of ferroptosis regulators in predicting prognosis and therapeutic strategies for osteosarcoma (OS) patients remains to be elucidated. Methods Here, we extracted transcriptomic and survival data from Therapeut...
Li, Qiaochu Chen, Zhiyu Yang, Chaohua Wang, Linbang Ma, Jingjin He, Tao Li, Huanhuan Quan, Zhengxue
Published in
Frontiers in Genetics
Ankylosing spondylitis (AS) is a chronic progressive autoimmune disease with insidious onset, high rates of disability among patients, unknown pathogenesis, and no effective treatment. Ferroptosis is a novel type of regulated cell death that is associated with various cancers and diseases. However, its relation to AS is not clear. In the present st...
Zhang, Fan Zhen, Hualong Cheng, Hengshun Hu, Fengying Jia, Yunfei Huang, Binbin Jiang, Minmin
Published in
Frontiers in Cell and Developmental Biology
As one kind of endocrine disrupting chemical, di-(2-ethylhexyl) phthalate (DEHP) has been reported to cause liver dysfunction in epidemiological and experimental studies. Abnormal liver function in pregnancy is associated with adverse maternal and perinatal outcomes. Few studies have investigated the potential effect of gestational DEHP exposure on...
Zhang, Yinjiang Zhang, Yashuo Yao, Rongfei He, Xu Zhao, Linyi Zuo, Xiangyu Lu, Binan Pang, Zongran
Published in
Frontiers in Nutrition
Background Iron is an essential nutrient element, and iron metabolism is related to many diseases. Ferroptosis is an iron-dependent form of regulated cell death associated with ischemic stroke (IS). Hence, this study intended to discover and validate the possible ferroptosis-related genes involved in IS. Materials and methods GSE16561, GSE37587, an...
