Xie, Jing Lin, Dongmei Li, Jing Zhou, Tonghui Lin, Shuqian Lin, Zhanxi
Published in
Frontiers in Nutrition
Ganoderma lucidum polysaccharide peptide (GLPP) is one of the most abundant constituents of Ganoderma lucidum (G. lucidum), with a wide range of functional activities. The present study investigated the immunomodulatory effects of GLPP in cyclophosphamide (CTX)-induced immunosuppressive mice. The results showed that 100 mg/kg/day of GLPP administra...
Chen, Xiao Li, Shaoli Lin, Cuixia Zhang, Zhen Liu, Xiaoyan Wang, Chunhui Chen, Jun Yang, Binbin Yuan, Jing Zhang, Zheng
...
Published in
Frontiers in Nutrition
Colon cancer (CC) is a multistage disease and one of the most common cancers worldwide. Establishing an effective treatment strategies of early colon cancer is of great significance for preventing its development and reducing mortality. The occurrence of colon cancer is closely related to changes in the intestinal flora structure. Therefore, remode...
Chen, Liwei Zheng, Tingting Yang, Yifan Chaudhary, Prem Prashant Teh, Jean Pui Yi Cheon, Bobby K Moses, Daniela Schuster, Stephan C Schlundt, Joergen Li, Jun
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Published in
Gut microbes
The age-associated alterations in microbiomes vary across populations due to the influence of genetics and lifestyles. To the best of our knowledge, the microbial changes associated with aging have not yet been investigated in Singapore adults. We conducted shotgun metagenomic sequencing of fecal and saliva samples, as well as fecal metabolomics to...
Du, Xinhao Li, Qing Tang, Zhenzhen Yan, Li Zhang, Ling Zheng, Qiao Zeng, Xianghao Chen, Guimei Yue, Huawen Li, Jun
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Published in
Frontiers in Physiology
Objective: The gut microbiota and its metabolites are important for host physiological homeostasis, while dysbiosis is related to diseases including the development of cancers such as colorectal cancer (CRC). In this study, we characterized the relationship of an altered gut microbiome with the fecal metabolome in CRC patients in comparison with vo...
Mujagic, Zlatan Kasapi, Melpomeni Jonkers, Daisy Mae Garcia-Perez, Isabel Vork, Lisa Weerts, Zsa Zsa R M Serrano-Contreras, Jose Ivan Zhernakova, Alexandra Kurilshikov, Alexander Scotcher, Jamie
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Published in
Gut microbes
To gain insight into the complex microbiome-gut-brain axis in irritable bowel syndrome (IBS), several modalities of biological and clinical data must be combined. We aimed to identify profiles of fecal microbiota and metabolites associated with IBS and to delineate specific phenotypes of IBS that represent potential pathophysiological mechanisms. F...
Zou, Hong Zhang, Man Zhu, Xiaoting Zhu, Liyan Chen, Shuo Luo, Mingjing Xie, Qinglian Chen, Yue Zhang, Kangxi Bu, Qingyun
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Published in
Frontiers in Microbiology
Gut microbiota plays an important role in metabolic homeostasis. Previous studies demonstrated that ginsenoside Rb1 might improve obesity-induced metabolic disorders through regulating glucose and lipid metabolism in the liver and adipose tissues. Due to low bioavailability and enrichment in the intestinal tract of Rb1, we hypothesized that modulat...
Mujagic, Z Kasapi, M Jonkers, DMAE Garcia Perez, I Vork, L Weerts, ZZRM Serrano Contreras, JI Zhernakova, A Kurilshikov, A Scotcher, J
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To gain insight into the complex microbiome-gut-brain axis in irritable bowel syndrome (IBS) several modalities of biological and clinical data must be combined. We aimed to identify profiles of faecal microbiota and metabolites associated with IBS and to delineate specific phenotypes of IBS that represent potential pathophysiological mechanisms. F...
He, Zhiyuan Ma, Yulin Chen, Xu Liu, Shuai Xiao, Jianxin Wang, Yajing Wang, Wei Yang, Hongjian Li, Shengli Cao, Zhijun
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Published in
Frontiers in Nutrition
Calf diarrhea induced by enteroaggregative E. coli (EAEC) spreads fast among young ruminants, causing continuous hazard to dairy industry. Antimicrobial drug abuse aggravates the incidence rate of multi-drug resistant (MDR) extended-spectrum β-lactamase-producing E. coli (ESBL-EC). However, knowledge of detection and significance of disease-related...
Lyu, Yang Liu, Daisy Nguyen, Patrick Peters, Iain Heilmann, Romy M. Fievez, Veerle Hemeryck, Lieselot Y. Hesta, Myriam
Published in
Frontiers in Veterinary Science
Obesity is a common problem in dogs and overconsumption of energy-rich foods is a key factor. This study compared the inflammatory response and fecal metabolome of dogs fed a high-fat vs. a high-starch diet. Ten healthy lean adult beagles were equally allocated into two groups in a cross-over design. Each group received two diets in which fat (hors...
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Autism spectrum disorders (ASD) make up a heterogeneous group of neurodevelopmental disorders characterized by social and communication difficulties associated with repetitive and restrictive behaviors. Besides core features, metabolic imbalances, inflammation, gastrointestinal (GI) symptoms, and altered gut microbiota composition were often descri...
