Rose, Jordan Brian, Christian Pappa, Aglaia Panayiotidis, Mihalis I. Franco, Rodrigo
Published in
Frontiers in Neuroscience
In the brain, mitochondrial metabolism has been largely associated with energy production, and its dysfunction is linked to neuronal cell loss. However, the functional role of mitochondria in glial cells has been poorly studied. Recent reports have demonstrated unequivocally that astrocytes do not require mitochondria to meet their bioenergetics de...
Song, Jungbin Kim, Jiye Park, Hyo Jin Kim, Hocheol
Published in
Nutrients
Prunus persica and Nelumbo nucifera are major crops cultivated worldwide. In East Asia, both P. persica flowers and N. nucifera leaves are traditionally used for therapeutic purposes and consumed as teas for weight loss. Herein, we investigated the anti-obesity effects of an herbal extract mixture of P. persica and N. nucifera (HT077) and the under...
Balyan, Renu Gautam, Namrata Gascoigne, Nicholas R.J.
Published in
International Journal of Molecular Sciences
Understanding the various mechanisms that govern the development, activation, differentiation, and functions of T cells is crucial as it could provide opportunities for therapeutic interventions to disrupt immune pathogenesis. Immunometabolism is one such area that has garnered significant interest in the recent past as it has become apparent that ...
Hakamata, Yuki Toyomizu, Masaaki Kikusato, Motoi
Published in
The Journal of Poultry Science
The skeletal muscle growth rate is a major feature differentiating meat- and laying-type chickens. A large amount of ATP is required during skeletal muscle synthesis, in which mitochondrial energy production capacities play a significant role. Additionally, mitochondria may participate in muscle protein degradation via reactive oxygen species gener...
Deleye, Yann Karen Cotte, Alexia Hannou, Sarah Hennuyer, Nathalie Bernard, Lucie Derudas, Bruno Caron, Sandrine Legry, Vanessa Vallez, Emmanuelle Dorchies, Emilie
...
In addition to their well-known role in the control of cellular proliferation and cancer, cell cycle regulators are increasingly identified as important metabolic modulators. Several GWAS have identified SNPs near CDKN2A, the locus encoding for p16INK4a (p16), associated with elevated risk for cardiovascular diseases and type-2 diabetes development...
Makrecka-Kuka, Marina Korzh, Stanislava Videja, Melita Vilskersts, Reinis Sevostjanovs, Eduards Zharkova-Malkova, Olga Arsenyan, Pavel Kuka, Janis Dambrova, Maija Liepinsh, Edgars
...
Published in
Journal of cellular and molecular medicine
The suppression of energy metabolism is one of cornerstones of cardiac dysfunction in sepsis/endotoxaemia. To investigate the role of fatty acid oxidation (FAO) in the progression of inflammation-induced cardiac dysfunction, we compared the effects of FAO-targeting compounds on mitochondrial and cardiac function in an experimental model of lipopoly...
Steyn, Frederik J Li, Rui Kirk, Siobhan E Tefera, Tesfaye W Xie, Teresa Y Tracey, Timothy J Kelk, Dean Wimberger, Elyse Garton, Fleur C Roberts, Llion
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Published in
Brain Communications
Graphical Abstract
Genders, Amanda J. Holloway, Graham P. Bishop, David J.
Published in
International Journal of Molecular Sciences
As a major site of glucose uptake following a meal, skeletal muscle has an important role in whole-body glucose metabolism. Evidence in humans and animal models of insulin resistance and type 2 diabetes suggests that alterations in mitochondrial characteristics accompany the development of skeletal muscle insulin resistance. However, it is unclear ...
Motlagh Scholle, Leila Schieffers, Helena Al-Robaiy, Samiya Thaele, Annemarie Lehmann Urban, Diana Zierz, Stephan
Published in
Life
It is known that exposure to excess saturated fatty acids, especially palmitate, can trigger cellular stress responses interpreted as lipotoxicity. The effect of excessive free fatty acids on oxidative phosphorylation capacity in myoblasts of patients with the m.3243A>G mutation was evaluated with the mitochondrial (Mito) stress test using a Seahor...
Greenwell, Amanda A. Gopal, Keshav Ussher, John R.
Published in
Frontiers in Physiology
As the most metabolically demanding organ in the body, the heart must generate massive amounts of energy adenosine triphosphate (ATP) from the oxidation of fatty acids, carbohydrates and other fuels (e.g., amino acids, ketone bodies), in order to sustain constant contractile function. While the healthy mature heart acts omnivorously and is highly f...