Ganguly, Shinjini Naik, Divya Muskara, Andrew Mian, Omar Y
Published in
Endocrinology
Endocrine-driven malignancies, including breast and prostate cancer, are among the most common human cancers. The relationship between sex steroid hormones (eg, androgen, estrogen, and progesterone), their cognate receptors, and genomic stability lie at the center of endocrine-driven cancer development, progression, and therapeutic resistance. A va...
Jordan, V Craig
Published in
Endocrine-related cancer
Following the discovery and approval of the oral contraceptive, the pharmaceutical industry sought new opportunities for the regulation of reproduction. The discovery of the first non-steroidal anti-oestrogen MER25, with antifertility properties in laboratory animals, started a search for 'morning-after pills'. There were multiple options in the 19...
Márton, Éva Varga, Alexandra Széles, Lajos Göczi, Lóránd Penyige, András Nagy, Bálint Szilágyi, Melinda
Published in
International journal of molecular sciences
Exposure to physiological estrogens or xenoestrogens (e.g., zearalenone or bisphenol A) increases the risk for cancer. However, little information is available on their significance in ovarian cancer. We present a comprehensive study on the effect of estradiol, zearalenone and bisphenol A on the phenotype, mRNA, intracellular and cell-free miRNA ex...
Jan van Weelden, Willem; Reijnen, Casper; Küsters-Vandevelde, Heidi VN; Bulten, Johan; Bult, Peter; Leung, Samuel; Visser, Nicole CM; Santacana, Maria; Bronsert, Peter; Hirschfeld, Marc;
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BACKGROUND: there is no consensus on the cut-off for positivity of estrogen receptor (ER) and progesterone receptor (PR) in endometrial cancer (EC). Therefore we determined the cut-off value for ER and PR with the strongest prognostic impact on outcome. METHODS: immunohistochemical expression of ER and PR was scored as a percentage of positive EC c...
Imamura, Osamu Arai, Masaaki Dateki, Minori Oishi, Kazuhiko Takishima, Kunio
Published in
Journal of neurochemistry
Loss of oligodendrocytes, the myelin-forming cells of the central nervous system, and subsequent failure of myelin development result in serious neurological disorders such as multiple sclerosis. Using primary mouse embryonic neural stem cells (NSCs), we previously demonstrated that donepezil, an acetylcholinesterase inhibitor developed for the tre...
Danes, Jeanne M de Abreu, Andre L P Kerketta, Romica Huang, Yunping Palma, Flavio R Gantner, Benjamin N Mathison, Angela J Urrutia, Raul A Bonini, Marcelo G
Published in
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Inorganic arsenic (iAs/As2 O3 2- ) is an environmental toxicant found in watersheds around the world including in densely populated areas. iAs is a class I carcinogen known to target the skin, lungs, bladder, and digestive organs, but its role as a primary breast carcinogen remains controversial. Here, we examined a different possibility: that expo...
Khunger, Niti Kandhari, Rajat Singh, Avninder Ramesh, V
Published in
Dermatologic therapy
Melasma and facial pigmentary demarcation lines (FPDL) are common causes of patterned facial pigmentation that may mimic each other. There is a paucity of studies investigating these two conditions. The objective of this study was to make a detailed comparative analysis of these disorders. A clinical, dermoscopic, histopathological and immunohistoc...
Buscato, Melissa Davezac, Morgane Zahreddine, Rana Adlanmerini, Marine Métivier, Raphaël Fillet, Marianne Cobraiville, Gael Moro, Cedric Foidart, Jean Michel Lenfant, Françoise
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Estetrol (E4), a natural estrogen synthesized by the human fetal liver, is currently evaluated in phase III clinical studies as a new menopause hormone therapy. Indeed, E4 significantly improves vasomotor and genito-urinary menopausal symptoms and prevents bone demineralization. Compared to other estrogens, E4 was found to have limited effects on c...
Mamnoon, Babak Feng, Li Froberg, Jamie Choi, Yongki Sathish, Venkatachalem Mallik, Sanku
Published in
Molecular pharmaceutics
Uncontrolled cell growth, division, and lack of enough blood supply causes low oxygen content or hypoxia in cancerous tumor microenvironments. 17β-Estradiol (E2), an estrogen receptor (ER) ligand, can be incorporated on the surface of nanocarriers for targeted drug delivery to breast cancer cells overexpressing ER. In the present study, we synthesi...
Ahluwalia, Amrita Hoa, Neil Ge, Lisheng Blumberg, Bruce Levin, Ellis R
Published in
Endocrinology
Mesenchymal stem cells can differentiate into mature chondrocytes, osteoblasts, and adipocytes. Excessive and dysfunctional visceral adipocytes increase upon menopause and importantly contribute to altered metabolism in postmenopausal women. We previously showed both plasma membrane and nuclear estrogen receptors alpha (ERα) with endogenous estroge...