Gomes-Duarte, Andreia Bauer, Sebastian Venø, Morten T. Norwood, Braxton A. Henshall, David C. Kjems, Jørgen Rosenow, Felix Vangoor, Vamshidhar R. Pasterkamp, R. Jeroen
Published in
Frontiers in Genetics
Mesial temporal lobe epilepsy (mTLE) is a common form of epilepsy and is characterized by recurrent spontaneous seizures originating from the temporal lobe. The majority of mTLE patients develop pharmacoresistance to available anti-epileptic drugs (AEDs) while exhibiting severe pathological changes that can include hippocampal atrophy, neuronal dea...
Vega-García, Angélica Feria-Romero, Iris García-Juárez, Anais Munguia-Madera, Ana Ch. Montes-Aparicio, Alexia V. Zequeida-Muñoz, Esli Garcia-Albavera, Estefany Orozco-Suárez, Sandra
Published in
Frontiers in Behavioral Neuroscience
Neural hyperexcitability in the event of damage during early life, such as hyperthermia, hypoxia, traumatic brain injury, status epilepticus, or a pre-existing neuroinflammatory condition, can promote the process of epileptogenesis, which is defined as the sequence of events that converts a normal circuit into a hyperexcitable circuit and represent...
do Canto, Amanda M. Donatti, Amanda Geraldis, Jaqueline C. Godoi, Alexandre B. da Rosa, Douglas C. Lopes-Cendes, Iscia
Published in
Frontiers in Molecular Neuroscience
Epilepsies are chronic neurological diseases that affect approximately 2% of the world population. In addition to being one of the most frequent neurological disorders, treatment for patients with epilepsy remains a challenge, because a proportion of patients do not respond to the antiseizure medications that are currently available. This results i...
Salari, Valentina Mengoni, Francesca Del Gallo, Federico Bertini, Giuseppe Fabene, Paolo Francesco
Published in
International Journal of Molecular Sciences
Mesenchymal stem cells (MSCs) are multipotent adult cells with self-renewing capacities. MSCs display specific properties, such as the ability to repair damaged tissues, resulting in optimal candidates for cell therapy against degenerative diseases. In addition to the reparative functions of MSCs, growing evidence shows that these cells have potent...
Lévesque, Maxime Biagini, Giuseppe Avoli, Massimo
Published in
International Journal of Molecular Sciences
Neurosteroids are a family of compounds that are synthesized in principal excitatory neurons and glial cells, and derive from the transformation of cholesterol into pregnenolone. The most studied neurosteroids—allopregnanolone and allotetrahydrodeoxycorticosterone (THDOC)—are known to modulate GABAA receptor-mediated transmission, thus playing a ro...
Gage, Meghan Golden, Madison Putra, Marson Sharma, Shaunik Thippeswamy, Thimmasettappa
Published in
Annals of the New York Academy of Sciences
Sex differences in response to neurotoxicant exposure that initiates epileptogenesis are understudied. We used telemetry-implanted male and female adult rats exposed to an organophosphate (OP) neurotoxicant, diisopropylflourophosphate (DFP), to test sex differences in the severity of status epilepticus (SE) and the development of spontaneous recurr...
Kundrick, Erica Marrero-Rosado, Brenda Stone, Michael Schultz, Caroline Walker, Katie Lee-Stubbs, Robyn B de Araujo Furtado, Marcio Lumley, Lucille A
Published in
Annals of the New York Academy of Sciences
Chemical warfare nerve agent exposure leads to status epilepticus that may progress to epileptogenesis and severe brain pathology when benzodiazepine treatment is delayed. We evaluated the dose-response effects of delayed midazolam (MDZ) on toxicity induced by soman (GD) in the plasma carboxylesterase knockout (Es1-/- ) mouse, which, similar to hum...
Dyomina, Alexandra V. Zubareva, Olga E. Smolensky, Ilya V. Vasilev, Dmitry S. Zakharova, Maria V. Kovalenko, Anna A. Schwarz, Alexander P. Ischenko, Alexander M. Zaitsev, Aleksey V.
Published in
Pharmaceuticals
Temporal lobe epilepsy is a widespread chronic disorder that manifests as spontaneous seizures and is often characterized by refractoriness to drug treatment. Temporal lobe epilepsy can be caused by a primary brain injury; therefore, the prevention of epileptogenesis after a primary event is considered one of the best treatment options. However, a ...
Jacobs, Julia Zijlmans, Maeike
Published in
Epilepsy Currents
The study of high frequency oscillations (HFO) in the electroencephalogram (EEG) as biomarkers of epileptic activity has merely focused on their spatial location and relationship to the epileptogenic zone. It has been suggested in several ways that the amount of HFO at a certain point in time may reflect the disease activity or severity. This could...
Lam, Alice D. Noebels, Jeffrey
Published in
Epilepsy Currents
Aberrant cortical network excitability is an inextricable feature of Alzheimer disease (AD) that can negatively impact memory and accelerate cognitive decline. Surface electroencephalogram spikes and intracranial recordings of nocturnal silent seizures in human AD, coupled with the abnormal neural synchrony that precedes development of behavioral s...
