Povečana raven sinaptotagmina IV v možganih podgan na modelih ekscitotoksičnih poškodb, povzročenih s kainsko in kinolin...
Neuroprotective Effects of the Anti-cancer Drug Lapatinib Against Epileptic Seizures via Suppressing Glutathione Peroxid...
Published in Frontiers in Pharmacology
Epilepsy is a complex neurological disorder characterized by recurrent and unprovoked seizures. Neuronal death process is implicated in the development of repetitive epileptic seizures. Therefore, cell death can be harnessed for ceasing seizures and epileptogenesis. Oxidative stress is regarded as a contributing factor of neuronal death activation ...
In Vitro and In Vivo Study of the Short-Term Vasomotor Response during Epileptic Seizures
Published in Brain Sciences
Epilepsy remains one of the most common brain disorders, and the different types of epilepsy encompass a wide variety of physiological manifestations. Clinical and preclinical findings indicate that cerebral blood flow is usually focally increased at seizure onset, shortly after the beginning of ictal events. Nevertheless, many questions remain abo...
The Diagnostic Challenge of Seronegative Autoimmune Encephalitis With Super-Refractory Status Epilepticus
Published in Cureus
Autoimmune encephalitis is an immune-mediated syndrome, with sub-acute to chronic presentations, such as memory impairment, altered sensorium, behavioral abnormality, psychosis, and seizures. It poses a two-fold diagnostic challenge: firstly, because of its variable clinical presentation and secondly, due to the wide variety of autoimmune antibodie...
Foreign Body Aspiration – A Potentially Life-Threatening Complication of Seizures
Published in Cureus
In adults, foreign body aspiration is an uncommon clinical presentation. Aspiration can occur during a seizure and in the post-ictal period due to the loss of airway reflexes. Commonly aspirated contents include saliva, blood, or vomited gastric contents. Due to a common misconception that placing an object, such as a spoon, in a seizing person’s m...
Perampanel reduces paroxysmal depolarizing shift and inhibitory synaptic input in excitatory neurons to inhibit epilepti...
Published in British journal of pharmacology
Perampanel is a newly approved anticonvulsant uniquely targeting AMPA receptors, which mediate the most abundant form of excitatory synaptic transmission in the brain. However, the network mechanism underlying the anti-epileptic effect of the AMPAergic inhibition remains to be explored. The mechanism of perampanel action was studied with the basola...
Antibiotic-induced epileptic seizures: mechanisms of action and clinical considerations.
Published in Seizure
In recent years, there has been growing interest in the development of epileptic seizures as an adverse effect of antibiotic therapy. The most commonly accepted mechanisms underlying the development of antibiotic-induced seizures include direct- and indirect gamma-aminobutyric acid (GABA) antagonism, inhibition of GABA synthesis, and glutaminergic ...
Complexity analysis and dynamic characteristics of EEG using MODWT based entropies for identification of seizure onset.
Published in Journal of biomedical research
Electric source imaging for presurgical epilepsy evaluation: current status and future prospects.
Published in Expert review of medical devices
Introduction: Electric source imaging (ESI) refers to the estimation of the cerebral sources of electric signals recorded at the head surface using electroencephalography (EEG). Thanks to the availability of EEG systems with high numbers of electrodes and to progress in software to analyze the signals they collect, ESI can be applied to epilepsy-re...
Treatment of Epilepsy Associated with Common Chromosomal Developmental Diseases
Published in Open Life Sciences
Chromosomal diseases are heterogeneous conditions with complex phenotypes, which include also epileptic seizures. Each chromosomal syndrome has a range of specific characteristics regarding the type of seizures, EEG findings and specific response to antiepileptic drugs, significant in the context of the respective genetic etiology. Therefore, it is...
