Lin, Simeng Hannon, Eilis Reppell, Mark Waring, Jeffrey F Smaoui, Nizar Pivorunas, Valerie Guay, Heath Chanchlani, Neil Bewshea, Claire Bai, Benjamin Y H
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Published in
Journal of Crohn's & colitis
Anti-tumour necrosis factor [TNF] treatment failure in patients with inflammatory bowel disease [IBD] is common and frequently related to low drug concentrations. In order to identify patients who may benefit from dose optimisation at the outset of anti-TNF therapy, we sought to define epigenetic biomarkers in whole blood at baseline associated wit...
Wang, SiYuan Liu, Qin
Published in
Frontiers in Oncology
Recent advances in genomic research have increasingly focused on the fat mass- and obesity-associated (FTO) gene due to its notable correlation with obesity. Initially explored for its contribution to increased body weight, FTO was later discovered to function as an m6A demethylase. This pivotal role enhances our understanding of its broader implic...
Kumar, Raj Gupta, Romi
Published in
Frontiers in Oncology
Epigenetic modifications influence gene expression and effects cancer initiation and progression. Therefore, they serve as diagnostic and prognostic biomarkers and potential therapeutic targets. Natural Killer (NK) cells, integral to the innate immune system, exhibit anti-tumor effect by recognizing and eliminating cancerous cells through the balan...
Clayton, Nicholas Pellei, David Lin, Zhao
Published in
Molecular oral microbiology
Periodontitis is one of the most common inflammatory diseases in humans. The susceptibility to periodontitis is largely determined by the host response, and the severity of inflammation predicts disease progression. Upon microbial insults, host cells undergo massive changes in their transcription program to trigger an appropriate response (inflamma...
Yue, Yi Ren, Yuqing Lu, Chunya Li, Ping Zhang, Guojun
Published in
Frontiers in Immunology
Regulatory T cells (Tregs), characterized by the expression of Forkhead Box P3 (FOXP3), constitute a distinct subset of T cells crucial for immune regulation. Tregs can exert direct and indirect control over immune homeostasis by releasing inhibitory factors or differentiating into Th-like Treg (Th-Treg), thereby actively contributing to the preven...
Tian, Yu Wang, Yu-fan Miao, Yi-liang Zhou, Li-quan
Published in
Frontiers in Genetics
Pedersen, Elisabeth A. Verhaegen, Monique E. Joseph, Mallory K. Harms, Kelly L. Harms, Paul W.
Published in
Frontiers in Oncology
Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma thought to arise via either viral (Merkel cell polyomavirus) or ultraviolet-associated pathways. Surgery and radiotherapy have historically been mainstays of management, and immunotherapy has improved outcomes for advanced disease. However, there remains a lack of effec...
Farhana, Aisha Yusuf, Nabiha Rasheed, Zafar
Published in
Frontiers in Genetics
Deinichenko, Kseniia A. Vynogradskaya, Valentina G. Grebnev, Pavel A. Mikova, Valeriya M. Bobylev, Dmitriy O. Shaymardanov, Abusaid M. Ivashechkin, Alexey A. Erokhina, Marina V. Akinshina, Alexandra I. Semyanihina, Anna V.
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Published in
Frontiers in Epigenetics and Epigenomics
Introduction: Whole-genome DNA methylation identification is crucial for profiling physiologically and clinically relevant epigenetic changes. Although there are multiple experimental methods, their accuracy, advantages, and disadvantages need to be investigated in their application to complex tissue objects. In this study, we performed a benchmark...
Bisserier, Malik Martelotto, Luciano G. El-Osta, Assam Mathiyalagan, Prabhu
Published in
Frontiers in Genetics
