He, Junping Yao, Lu Pecoraro, Lorenzo Liu, Changxiao Wang, Juan Huang, Luqi Gao, Wenyuan
Published in
Critical reviews in biotechnology
Plants make different defense mechanisms in response to different environmental stresses. One common way is to produce secondary metabolites. Temperature is the main environmental factor that regulates plant secondary metabolites, especially flavonoids and terpenoids. Stress caused by temperature decreasing to 4-10 °C is conducive to the accumulati...
Knowles, Liam G Armanious, Abanoub J Peng, Youyi Welsh, William J James, Morgan H
Published in
Addiction neuroscience
Psychiatric disorders characterized by uncontrolled reward seeking, such as substance use disorders (SUDs), alcohol use disorder (AUD) and some eating disorders, impose a significant burden on individuals and society. Despite their high prevalence and substantial morbidity and mortality rates, treatment options for these disorders remain limited. O...
Zhang, Jiahui Lee, Pui Y. Aksentijevich, Ivona Zhou, Qing
Systemic autoinflammatory diseases (SAIDs) are a heterogeneous group of disorders caused by excess activation of the innate immune system in an antigen-independent manner. Starting with the discovery of the causal gene for familial Mediterranean fever, more than 50 monogenic SAIDs have been described. These discoveries, paired with advances in immu...
Sun, Bo Reynolds, Kurt S Garland, Michael A McMahon, Moira Saha, Subbroto K Zhou, Chengji J
Published in
Birth defects research
Orofacial clefts (OFCs) are one of the most common types of structural birth defects. The etiologies are complicated, involving with genetic, epigenetic, and environmental factors. Studies have found that maternal diabetes and metabolic syndrome are associated with a higher risk of OFCs in offspring. Metabolic syndrome is a clustering of several di...
Golding, Michael C
Published in
Birth defects research
Until recently, clinicians and researchers did not realize paternal exposures could impact child developmental outcomes. Indeed, although there is growing recognition that sperm carry a large amount of non-genomic information and that paternal stressors influence the health of the next generation, toxicologists are only now beginning to explore the...
Girard, Fabien Even, Antoine Thierry, Agnès Ruault, Myriam Meneu, Léa Adiba, Sandrine Taddei, Angela Koszul, Romain Cournac, Axel
Abstract Natural plasmids are common in prokaryotes but few have been documented in eukaryotes. The natural 2µ plasmid present in budding yeast Saccharomyces cerevisiae is one of the most well characterized. This highly stable genetic element coexists with its host for millions of years, efficiently segregating at each cell division through a mecha...
González, Jessica Bosch-Presegué, Laia Marazuela-Duque, Anna Guitart-Solanes, Anna Espinosa-Alcantud, María Fernandez, Agustín F. Brown, Jeremy P. Ausió, Juan Vazquez, Berta N. Singh, Prim B.
...
Published in
Frontiers in Cell and Developmental Biology
Pericentric heterochromatin (PCH) plays an essential role in the maintenance of genome integrity and alterations in PCH have been linked to cancer and aging. HP1 α, β, and γ, are hallmarks of constitutive heterochromatin that are thought to promote PCH structure through binding to heterochromatin-specific histone modifications and interaction with ...
Sandoval, Cristian Nahuelqueo, Karen Mella, Luciana Recabarren, Blanca Souza-Mello, Vanessa Farías, Jorge
Published in
Frontiers in Nutrition
Introduction There exists a correlation between obesity and the consumption of an excessive amount of calories, with a particular association between the intake of saturated and trans fats and an elevated body mass index. Omega-3 fatty acids, specifically eicosapentaenoic and docosahexaenoic acids, have been identified as potential preventive nutri...
Moissiard, Guillaume Mirouze, Marie Carles, Cristel C. Vitte, Clémentine
Published in
Frontiers in Plant Science
Dindi, Uma Maheswara Rao Sadiq, Suhadha Parveen Al-Ghamdi, Sameer Alrudian, Naif Abdurhman Dayel, Salman Bin Abuderman, Abdulwahab Ali Shahid, Mohammad Ramesh, Thiyagarajan Vilwanathan, Ravikumar
Published in
Frontiers in Medicine
Introduction Epigenetic enzymes can interact with a wide range of genes that actively participate in the progression or repression of a diseased condition, as they are involved in maintaining cellular homeostasis. Sirtuins are a family of Class III epigenetic modifying enzymes that regulate cellular processes by removing acetyl groups from proteins...
