Lee, Valerie Parkinson, Rose Zahurak, Marianna Cope, Leslie Cercek, Andrea Verheul, Henk Gootjes, Elske Lenz, Heinz Josef Iqbal, Syma Jones, Peter
...
Published in
International journal of cancer
DNA methyltransferase inhibitors (DNMTi) have demonstrated benefit in reversing resistance to systemic therapies for several cancer types. In a phase II trial of guadecitabine and irinotecan compared to regorafenib or TAS-102 in pts with advanced mCRC refractory to irinotecan. Patients with mCRC refractory to irinotecan were randomized 2:1 to guade...
Yin, Jun Gu, Tiezheng Chaudhry, Norin Davidson, Nancy E. Huang, Yi
Published in
Frontiers in Immunology
Breast cancer (BC) is the most common non-skin cancer and the second leading cause of cancer death in American women. The initiation and progression of BC can proceed through the accumulation of genetic and epigenetic changes that allow transformed cells to escape the normal cell cycle checkpoint control. Unlike nucleotide mutations, epigenetic cha...
Sirajudeen, Shaima Shah, Iltaf Karam, Sherif M Al Menhali, Asma
Published in
Nutrients
Vitamin D (VD) deficiency can result from insufficiency of either light exposure or VD intake. We investigated the biological effects of VD deficiency for 7 months on the mouse gastric glands. Varying degrees of VD deficiency were induced in C57BL/6 mice by keeping them on standard diet with constant-dark conditions (SDD) or VD deficient diet with ...
Carty, Shannon A.
Published in
Frontiers in Oncology
Peripheral T cell lymphomas (PTCL) are a heterogenous group of mature T cell lymphomas with an overall poor prognosis. Understanding the molecular heterogeneity in PTCL subtypes may lead to improved understanding of the underlying biological mechanisms driving these diseases. Mutations in the epigenetic regulator TET2 are among the most frequent mu...
Norollahi, Seyedeh Elham Vahidi, Sogand Shams, Shima Keymoradzdeh, Arman Soleymanpour, Armin Solymanmanesh, Nazanin Mirzajani, Ebrahim Jamkhaneh, Vida Baloui Samadani, Ali Akbar
Published in
Hormone Molecular Biology and Clinical Investigation
DNA methylation is the most important epigenetic element that activates the inhibition of gene transcription and is included in the pathogenesis of all types of malignancies. Remarkably, the effectors of DNA methylation are DNMTs (DNA methyltransferases) that catalyze de novo or keep methylation of hemimethylated DNA after the DNA replication proce...
Guan, Qianting Han, Meiwen Guo, Qinghao Yan, Fangfei Wang, Ming Ning, Qin Xi, Dong
Published in
Frontiers in Immunology
CD8+ T cell exhaustion is a stable dysfunctional state driven by chronic antigen stimulation in the tumor microenvironment (TME). Differentiation of exhausted CD8+ T cells (CD8+ TEXs) is accompanied by extensive transcriptional, epigenetic and metabolic reprogramming. CD8+ TEXs are mainly characterized by impaired proliferative and cytotoxic capaci...
Ullrich, Sarah J Yung, Nicholas K Bauer-Pisani, Tory J Maassel, Nathan L Guerra, Mary Elizabeth Freedman-Weiss, Mollie Ahle, Samantha L Ricciardi, Adele S Sauler, Maor Saltzman, W Mark
...
Published in
Molecular therapy. Nucleic acids
Structural fetal diseases, such as congenital diaphragmatic hernia (CDH) can be diagnosed prenatally. Neonates with CDH are healthy in utero as gas exchange is managed by the placenta, but impaired lung function results in critical illness from the time a baby takes its first breath. MicroRNA (miR) 200b and its downstream targets in the TGF-β pathw...
sahafnejad;, zahra
Epigenetics has long been recognized as a significant field in biology and is defined as the investigation of any alteration in gene expression patterns that is not attributed to changes in the DNA sequences. Epigenetic marks, including histone modifications, non-coding RNAs, and DNA methylation, play crucial roles in gene regulation. Numerous stud...
sulewska;, anetta
Epigenetic research has the potential to improve our understanding of the pathogenesis of cancer, specifically non-small-cell lung cancer, and support our efforts to personalize the management of the disease. Epigenetic alterations are expected to have relevance for early detection, diagnosis, outcome prediction, and tumor response to therapy. Addi...
m., juha
Age-related macular degeneration (AMD) is an ever-increasing, insidious disease which reduces the quality of life of millions of elderly people around the world. AMD is characterised by damage to the retinal pigment epithelium (RPE) in the macula region of the retina. The origins of this multi-factorial disease are complex and still not fully under...
