Calanca, Naiade Abildgaard, Cecilie Rainho, Cláudia Aparecida Rogatto, Silvia Regina
Published in
Cancers
Simple Summary Epithelial ovarian cancer is an aggressive disease associated with relapse, resistance to chemotherapy, and high mortality rates. Recent discoveries have pointed out that long noncoding RNAs (lncRNAs) are potential biomarkers or therapeutic targets in several tumor types. However, fundamental knowledge about their functions and regul...
Qiu, Yi Huang, Suming
Published in
Leukemia
Recent technological advancements and genome-wide studies provide compelling evidence that dynamic chromatin interaction and three-dimensional genome organization in nuclei play an important role in regulating gene expression. Mammalian genomes consist of many small functional domains termed topologically associated domains (TADs), many of them org...
Chen, Jian Clinton, Michael Qi, Guang Wang, Daowen Liu, Fengquan Fu, Zheng Qing
Published in
Journal of experimental botany
As a plant hormone, salicylic acid (SA) plays essential roles in plant defense against biotrophic and hemibiotrophic pathogens. Significant progress has been made in understanding the SA biosynthesis pathways and SA-mediated defense signaling networks in the past two decades. Plant defense responses involve rapid and massive transcriptional reprogr...
Emran, Abdullah Al Nsengimana, Jérémie Punnia-Moorthy, Gaya Schmitz, Ulf Gallagher, Stuart J. Newton-Bishop, Julia Tiffen, Jessamy C. Hersey, Peter
Published in
Cancers
Background: Survival from melanoma is strongly related to patient sex, with females having a survival rate almost twice that of males. Many explanations have been proposed but have not withstood critical scrutiny. Prior analysis of different cancers with a sex bias has identified six X-linked genes that escape X chromosome inactivation in females a...
Yang, Linqi Zhang, Wenqi Chopra, Saiyam Kaur, Deeepjyot Wang, Huibing Li, Meng Chen, Pingping Zhang, Wei
Published in
Current drug targets
Among the major components of green tea, epigallocatechin-3-gallate (EGCG) is the most effective for its anti-cancer characteristics. The bulk of studies provide the mechanisms of suppressive function of EGCG are involved in alteration of cancer cell cycle, development, and apoptosis through activation/inhibition of several signal pathways. Another...
Afrin, Sadia Giampieri, Francesca Gasparrini, Massimiliano Forbes-Hernández, Tamara Y Cianciosi, Danila Reboredo-Rodriguez, Patricia Zhang, Jiaojiao Manna, Piera Pia Daglia, Maria Atanasov, Atanas Georgiev
...
Published in
Biotechnology advances
Worldwide, colorectal cancer (CRC) remains a major cancer type and leading cause of death. Unfortunately, current medical treatments are not sufficient due to lack of effective therapy, adverse side effects, chemoresistance and disease recurrence. In recent decades, epidemiologic observations have highlighted the association between the ingestion o...
Markopoulos, Georgios S. Roupakia, Eugenia Marcu, Kenneth B. Kolettas, Evangelos
Published in
Cells
The neoplastic transformation of normal to metastatic cancer cells is a complex multistep process involving the progressive accumulation of interacting genetic and epigenetic changes that alter gene function and affect cell physiology and homeostasis. Epigenetic changes including DNA methylation, histone modifications and changes in noncoding RNA e...
Forini, Francesca Nicolini, Giuseppina Pitto, Letizia Iervasi, Giorgio
Published in
Frontiers in Endocrinology
Thyroid hormone (TH) signaling is critically involved in the regulation of cardiovascular physiology. Even mild reductions of myocardial TH levels, as occur in hypothyroidism or low T3 state conditions, are thought to play a role in the progression of cardiac disorders. Due to recent advances in molecular mechanisms underlying TH action, it is now ...
Shafran, Jordan S Andrieu, Guillaume P Györffy, Balázs Denis, Gerald V
Published in
Molecular cancer research : MCR
The inevitable progression of advanced prostate cancer to castration resistance, and ultimately to lethal metastatic disease, depends on primary or acquired resistance to conventional androgen deprivation therapy (ADT) and accumulated resistance strategies to evade androgen receptor (AR) suppression. In prostate cancer cells, AR adaptations that ar...
Eder-Azanza, Laura Hurtado, Cristina Navarro-Herrera, David Calavia, Diego Novo, Francisco Javier Vizmanos, José Luis
Published in
Molecular and Clinical Oncology
In recent years it has been shown that the causes of chronic myeloproliferative neoplasms (MPNs) are more complex than a simple signaling aberration and many other mutated genes affecting different cell processes have been described. For instance, mutations in genes encoding epigenetic regulators are more frequent than expected. One of the latest g...