Wang, Yaping Li, Xiaobo Ren, Shunlin
Published in
Metabolites
Oxysterols have long been believed to be ligands of nuclear receptors such as liver × receptor (LXR), and they play an important role in lipid homeostasis and in the immune system, where they are involved in both transcriptional and posttranscriptional mechanisms. However, they are increasingly associated with a wide variety of other, sometimes sur...
Maitra, Swati Khandelwal, Nitin Kootar, Scherazad Sant, Pooja Pathak, Salil S. Reddy, Sujatha K., Annapoorna P. Murty, Upadhyayula Suryanarayana Chakravarty, Sumana Kumar, Arvind
...
Published in
Brain Sciences
Depression, anxiety and related mood disorders are major psychiatric illnesses worldwide, and chronic stress appears to be one of the primary underlying causes. Therapeutics to treat these debilitating disorders without a relapse are limited due to the incomplete molecular understanding of their etiopathology. In addition to the well-studied geneti...
Albanesi, Jacopo Noguera, Nelida Ines Banella, Cristina Colangelo, Tommaso De Marinis, Elisabetta Leone, Stefano Palumbo, Orazio Voso, Maria Teresa Ascenzi, Paolo Nervi, Clara
...
Published in
Cells
Acute promyelocytic leukemia (APL) is a hematological disease characterized by a balanced reciprocal translocation that leads to the synthesis of the oncogenic fusion protein PML-RARα. APL is mainly managed by a differentiation therapy based on the administration of all- trans retinoic acid (ATRA) and arsenic trioxide (ATO). However, therapy resist...
Calanca, Naiade Abildgaard, Cecilie Rainho, Cláudia Aparecida Rogatto, Silvia Regina
Published in
Cancers
Simple Summary Epithelial ovarian cancer is an aggressive disease associated with relapse, resistance to chemotherapy, and high mortality rates. Recent discoveries have pointed out that long noncoding RNAs (lncRNAs) are potential biomarkers or therapeutic targets in several tumor types. However, fundamental knowledge about their functions and regul...
Qiu, Yi Huang, Suming
Published in
Leukemia
Recent technological advancements and genome-wide studies provide compelling evidence that dynamic chromatin interaction and three-dimensional genome organization in nuclei play an important role in regulating gene expression. Mammalian genomes consist of many small functional domains termed topologically associated domains (TADs), many of them org...
Chen, Jian Clinton, Michael Qi, Guang Wang, Daowen Liu, Fengquan Fu, Zheng Qing
Published in
Journal of experimental botany
As a plant hormone, salicylic acid (SA) plays essential roles in plant defense against biotrophic and hemibiotrophic pathogens. Significant progress has been made in understanding the SA biosynthesis pathways and SA-mediated defense signaling networks in the past two decades. Plant defense responses involve rapid and massive transcriptional reprogr...
Emran, Abdullah Al Nsengimana, Jérémie Punnia-Moorthy, Gaya Schmitz, Ulf Gallagher, Stuart J. Newton-Bishop, Julia Tiffen, Jessamy C. Hersey, Peter
Published in
Cancers
Background: Survival from melanoma is strongly related to patient sex, with females having a survival rate almost twice that of males. Many explanations have been proposed but have not withstood critical scrutiny. Prior analysis of different cancers with a sex bias has identified six X-linked genes that escape X chromosome inactivation in females a...
Yang, Linqi Zhang, Wenqi Chopra, Saiyam Kaur, Deeepjyot Wang, Huibing Li, Meng Chen, Pingping Zhang, Wei
Published in
Current drug targets
Among the major components of green tea, epigallocatechin-3-gallate (EGCG) is the most effective for its anti-cancer characteristics. The bulk of studies provide the mechanisms of suppressive function of EGCG are involved in alteration of cancer cell cycle, development, and apoptosis through activation/inhibition of several signal pathways. Another...
Afrin, Sadia Giampieri, Francesca Gasparrini, Massimiliano Forbes-Hernández, Tamara Y Cianciosi, Danila Reboredo-Rodriguez, Patricia Zhang, Jiaojiao Manna, Piera Pia Daglia, Maria Atanasov, Atanas Georgiev
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Biotechnology advances
Worldwide, colorectal cancer (CRC) remains a major cancer type and leading cause of death. Unfortunately, current medical treatments are not sufficient due to lack of effective therapy, adverse side effects, chemoresistance and disease recurrence. In recent decades, epidemiologic observations have highlighted the association between the ingestion o...
Markopoulos, Georgios S. Roupakia, Eugenia Marcu, Kenneth B. Kolettas, Evangelos
Published in
Cells
The neoplastic transformation of normal to metastatic cancer cells is a complex multistep process involving the progressive accumulation of interacting genetic and epigenetic changes that alter gene function and affect cell physiology and homeostasis. Epigenetic changes including DNA methylation, histone modifications and changes in noncoding RNA e...
