Qu, Rirong Tu, Dehao Ping, Wei Zhang, Ni Fu, Xiangning
Published in
OncoTargets and therapy
Background There is no consensus on whether patients with synchronous multiple lung cancers (SMLC) who present with lymph node metastasis (LNM) but whose epidermal growth factor receptor (EGFR) mutations are different are considered to have intrapulmonary metastases or multiple primary lung cancers. Few studies on these patients have been reported....
Huang, Yi-Shu Hsu, Wei-Chuan Lin, Chien-Hong Lo, Sheng-Nan Cheng, Chu-Nian Lin, Ming-Syuan Lee, Te-Wei Chang, Chih-Hsien Lan, Keng-Li
Published in
International journal of molecular sciences
Epidermal growth factor receptor (EGFR) specific therapeutics is of great importance in cancer treatment. Fcy-hEGF fusion protein, composed of yeast cytosine deaminase (Fcy) and human EGF (hEGF), is capable of binding to EGFR and enzymatically convert 5-fluorocytosine (5-FC) to 1000-fold toxic 5-fluorocuracil (5-FU), thereby inhibiting the growth o...
Song, Hai Wang, Yanpei Shi, Chaojia Lu, Jianxiang Yuan, Tian Wang, Xiangpeng
Published in
Frontiers in Oncology
Glioblastoma (GBM) is the most common and aggressive brain tumor in adults. Overexpression or activation of epidermal growth factor receptor (EGFR) occurs commonly in multiple human cancers and promotes tumorigenesis. However, the underlying molecular mechanism of EGFR aberrant activation and the downstream signaling pathways remains largely unknow...
DOĞAN, Eda DÜZGÜN, Zekeriya YILDIRIM, Zafer ÖZDİL, Berrin AKTUĞ, Hüseyin BOZOK ÇETİNTAŞ, Vildan
Published in
Turkish Journal of Biology
PIKfyve is an evolutionarily conserved lipid and protein kinase enzyme that has pleiotropic cellular functions. The aim of the present study was to investigate the effects of phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) inhibitor, YM201636, on nonsmall cell lung cancer (NSCLC) cells growth, tumorigenicity, and claudin (CLDN) expressions. Thr...
Wang, Yubo Han, Rui Wang, Qiushi Zheng, Jie Lin, Caiyu Lu, Conghua Li, Li Chen, Hengyi Jin, Rongbing He, Yong
...
Published in
International Journal of General Medicine
Purpose To investigate the potential of maximum standardized uptake value (SUVmax) in predicting epidermal growth factor receptor ( EGFR ) mutation status in non-small cell lung cancer (NSCLC) patients. Methods Clinical data of 311 NSCLC patients who had undergone both EGFR mutation test and 18F-FDG PET/CT scans between January 2013 and December 20...
Zhang, Yang Fu, Fangqiu Hu, Haichuan Wang, Shengping Li, Yuan Hu, Hong Chen, Haiquan
Published in
The Journal of thoracic and cardiovascular surgery
Currently, limited data on tyrosine kinase inhibitors as neoadjuvant therapy exist. This prospective study aimed to investigate the efficacy and safety of preoperative gefitinib in patients with stage II-IIIA operable non-small cell lung cancer (NSCLC). This was a single-arm, phase II trial performed in the Shanghai Cancer Center. Between August 20...
Zhang, Ying-Ying Chen, Jing-Jie Li, Dan-Qi Zhang, Yan- Wang, Xiao-Bo Yao, Guo-Dong Song, Shao-Jiang
Published in
Natural product research
Vibsane-type diterpenes, the characteristic compounds of Viburnum odoratissimum, exhibited significant cytotoxicity in many cancer cells. To search for the potential target of vibsane-type diterpenes on lung cancer, we combined methods of network pharmacology prediction and experimental verification. 80 active ingredients, 23 potential targets and ...
Miao, Emily Seetharamu, Nagashree Sullivan, Kevin Eng, Stephen Lee, Chung-Shien
Published in
Journal of pharmacy practice
Epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) can cause intolerable adverse events in patients with non-small cell lung cancer (NSCLC) and may be prescribed at a lower dose. Our objective was to analyze the starting doses of oral EGFR and ALK TKIs in patients diagnosed with NSCLC at o...
Shen, Yue Ji, Chenxing Jian, Xuemin Zhou, Juan Zhang, Qilin Qiao, Nidan Zhang, Yichao Shou, Xuefei Zhou, Xiang Ma, Zengyi
...
Published in
Frontiers in Endocrinology
Purpose To investigate the role of heat-shock protein Hsp90 in adrenocorticotropic hormone (ACTH)-secreting cells, and to explore the potential clinical application of an inhibitor of Hsp90, 17-N-allylamino-17-demethoxygeldanamycin(17-AAG) in corticotropinomas [also known as “Cushing’s disease” (CD)]. Methods Culture of mouse pituitary tumor [AtT-2...
Wen, Zhili Feng, Yuliang Hu, Youwen Lian, Lingyan Huang, Hongyan Guo, Li Chen, Shanwen Yang, Qian Zhang, Moran Wan, Lijun
...
Published in
Aging (Albany NY)
Objective: This study aimed to investigate the effects of multiwalled carbon nanotubes (MWNTs) co-delivering sorafenib (Sor) and epidermal growth factor receptor (EGFR) siRNA (MWNT/Sor/siRNA) on tumor growth in liver cancer (LC). Results: MWNT/Sor/siRNA was proved to possess increased Sor release, high siRNA stability, and enhanced cellular uptake....
