DeMayo, Francesco J Lydon, John P
Published in
Journal of molecular endocrinology
Progesterone's ability to maintain pregnancy in eutherian mammals highlighted this steroid as the 'hormone of pregnancy'. It was the unique 'pro-gestational' bioactivity of progesterone that enabled eventual purification of this ovarian steroid to crystalline form by Willard Myron Allen in the early 1930s. While a functional connection between norm...
paukszto, lukasz mikolajczyk, anita jastrzebski, jan p. majewska, marta dobrzyn, kamil kiezun, marta smolinska, nina kaminski, tadeusz
Endometrial infections at a young age can lead to fertility issues in adulthood. Bacterial endotoxins, such as lipopolysaccharide (LPS), can participate in long-term molecular changes even at low concentrations. Lipopolysaccharide plays a crucial role in the progression of septic shock, inflammation and auto-immune diseases. The aim of this study w...
shu-wing, ng norwitz, gabriella a. pavlicev, mihaela tilburgs, tamara simón, carlos norwitz, errol r.
Interventions to prevent pregnancy complications have been largely unsuccessful. We suggest this is because the foundation for a healthy pregnancy is laid prior to the establishment of the pregnancy at the time of endometrial decidualization. Humans are one of only a few mammalian viviparous species in which decidualization begins during the latter...
Van den Bosch, T; 47968; Verbakel, JY; 42064; Valentin, L; Wynants, L; De Cock, B; 95171; Pascual, MA; Leone, FPG; Sladevicius, P; Alcazar, JL; Votino, A;
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OBJECTIVE: To describe the ultrasound features of different endometrial and other intracavitary pathologies in pre- and postmenopausal women presenting with abnormal uterine bleeding using the International Endometrial Tumor Analysis (IETA) terminology. METHODS: Prospective observational multicenter study of 2856 consecutive women presenting with a...
da gama, telo
Neutrophil extracellular traps (NETs) fight endometritis, and elastase (ELA), a protease found in NETs, might induce collagen type I (COL1) accumulation in equine endometrium. Metallopeptidases (MMPs) are involved in extracellular matrix balance. The aim was to evaluate the effects of ELA and sivelestat (selective elastase inhibitor) on MMP-2 and M...
pierzchała, mariusz pierzchała, dorota ogłuszka, magdalena poławska, ewa blicharski, tadeusz roszczyk, agnieszka nawrocka, agata urbański, pawel stepanow, kamila ciepłoch, aleksandra
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During the early stages of pregnancy, the uterine endometrium undergoes dramatic morphologic and functional changes accompanied with dynamic variation in gene expression. Pregnancy-stage specific differentially expressed gene (DEG)-transcript-probes were investigated and identified by comparing endometrium transcriptome at 9th day (9D), 12th day (1...
yao, ye lin, peng zhu, junyan jeschke, udo von schönfeldt, viktoria
Among prostaglandins, Prostaglandin E2 (PGE2) (PGE2) is considered especially important for decidualization, ovulation, implantation and pregnancy. Four major PGE2 receptor subtypes, EP1, EP2, EP3, EP4, as well as peroxisome proliferator-activated receptors (PPARs), mediate various PGE2 effects via their coupling to distinct signaling pathways. Thi...
pap, ramóna montskó, gergely jánosa, gergely sipos, katalin kovács, gábor l. pandur, edina
Embryo implantation is a complex process regulated by a network of biological molecules. Recently, it has been described that fractalkine (CX3CL1, FKN) might have an important role in the feto&ndash / maternal interaction during gestation since the trophoblast cells express fractalkine receptor (CX3CR1) and the endometrium cells secrete fractalkine...
zhang, peilin
Background: Wilm&rsquo / s tumor 1 gene (WT1) is a transcription factor with versatile cellular functions in embryonic development, the maintenance of adult tissue functions, and regeneration. WT1 is known to be regulated by progesterone and it is abundantly expressed in endometrium, but its function is unclear. Design: in this observational and de...
luddi, alice marrocco, camilla governini, laura semplici, bianca pavone, valentina luisi, stefano petraglia, felice piomboni, paola
Endometriosis is a condition defined as presence of endometrium outside of the uterine cavity. These endometrial cells are able to attach and invade the peritoneum or ovary, thus forming respectively the deep infiltrating endometriosis (DIE) and the ovarian endometrioma (OMA), the ectopic lesions feature of this pathology. Endometriotic cells displ...
