barman, dibyasri drolia, rishi
Within mammalian cells, diverse endocytic mechanisms, including phagocytosis, pinocytosis, and receptor-mediated endocytosis, serve as gateways exploited by many bacterial pathogens and toxins. Among these, caveolae-mediated endocytosis is characterized by lipid-rich caveolae and dimeric caveolin proteins. Caveolae are specialized microdomains on c...
Stanco, Deborah Lipsa, Dorelia Bogni, Alessia Bremer-Hoffmann, Susanne Clerbaux, Laure-Alix
Published in
Frontiers in Toxicology
Introduction The ingestion of nanomaterials (NMs) may impair the intestinal barrier, but the underlying mechanisms remain evasive, and evidence has not been systematically gathered or produced. A mechanistic-based approach would be instrumental in assessing whether relevant NMs disrupt the intestinal barrier, thereby supporting the NM risk assessme...
kurabi, arwa yuge, xu chavez, eduardo khieu, vivian ryan, allen f.
The tympanic membrane forms an impenetrable barrier between the ear canal and the air-filled middle ear, protecting it from fluid, pathogens, and foreign material entry. We previously screened a phage display library and discovered peptides that mediate transport across the intact membrane. The route by which transport occurs is not certain, but po...
varalda, marco venetucci, jacopo nikaj, herald kankara, chaitanya reddy garro, giulia keivan, nazanin bettio, valentina marzullo, paolo antona, annamaria valente, guido
...
Metabolic syndrome (MetS) is a cluster of metabolic abnormalities, including visceral obesity, dyslipidemia, and insulin resistance. In this regard, visceral white adipose tissue (vWAT) plays a critical role, influencing energy metabolism, immunomodulation, and oxidative stress. Adipose-derived stem cells (ADSCs) are key players in these processes ...
Liu, Hong Lin, Jianfeng Phan, Quynh Bruno, Vincent Filler, Scott
The epidermal growth factor receptor (EGFR) has been identified as an epithelial cell receptor for Mucorales fungi and Candida albicans. Blocking EGFR with small molecule inhibitors reduces disease severity in mouse models of mucormycosis and oropharyngeal candidiasis. In contrast, cases of invasive aspergillosis have been reported in cancer patien...
lempicki, camille milosavljevic, julian laggner, christian tealdi, simone meyer, charlotte walz, gerd lang, konrad campa, carlo cosimo hermle, tobias
RAB11, a pivotal RabGTPase, regulates essential cellular processes such as endocytic recycling, exocytosis, and autophagy. The protein was implicated in various human diseases, including cancer, neurodegenerative disorders, viral infections, and podocytopathies. However, a small-molecular inhibitor is lacking. The complexity and workload associated...
Ren, Jihui Rieger, Robert Pereira de Sa, Nivea Kelapire, Douglas Del Poeta, Maurizio Hannun, Yusuf A
Published in
Journal of lipid research
Sphingolipids (SPLs) are major components of cell membranes with significant functions. Their production is a highly-regulated multi-step process with the formation of two major intermediates, long chain bases (LCBs) and ceramides. Homologous Orm proteins in both yeast and mammals negatively regulate LCB production by inhibiting serine palmitoyltra...
Courreges, Christina J. F. Davenport, Elizabeth C. M. Bilanges, Benoit Rebollo-Gomez, Elena Hukelmann, Jens Schoenfelder, Priya Edgar, James R. Sansom, David Scudamore, Cheryl L. Roychoudhuri, Rahul
...
Published in
Frontiers in Immunology
Regulatory T (Treg) cells are essential for the maintenance of immunological tolerance, yet the molecular components required for their maintenance and effector functions remain incompletely defined. Inactivation of VPS34 in Treg cells led to an early, lethal phenotype, with massive effector T cell activation and inflammation, like mice lacking Tre...
koshimizu, karen ozawa, ren kuribayashi, sohei taru, maho iwata, hisataka miura, ryotaro hamano, seizo shirasuna, koumei
The existence of repeat breeder cows (RBCs) causes low reproductive performance. The causes of RBCs include low-quality oocytes and embryos, hormonal dysregulation, and unsuitable uterine environments. To improve unsuitable uterine conditions for RBCs, we focused on nobiletin (NOB), a natural citrus flavone with various beneficial roles. The role o...
Lampe, Robert H. Coale, Tyler H. McQuaid, Jeffrey B. Allen, Andrew E.
The micronutrient iron is essential for phytoplankton growth due to its central role in a wide variety of key metabolic processes including photosynthesis and nitrate assimilation. As a result of scarce bioavailable iron in seawater, marine primary productivity is often iron-limited with future iron supplies remaining uncertain. Although evolutiona...
